FB:ft

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	ft ( synonyms: 79/18, CG3352, CT11259, Dm Fat, FAT, Fat, Ft, floppy-discs, giant discs 2, giant-discs-1, l(2)24Da, l(2)79/18, l(2)fat, l(2)fd, l(2)ft, l(2)gd-1, l(2)gd-l, l(2)gd2, l(2)k07918 )
Protein Name(s)	fat,
External Links
FB	FBgn0001075

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000904	cell morphogenesis involved in differentiation	FB:FBrf0053397 PMID:1959133^[1]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001736	establishment of planar polarity	FB:FBrf0194266 PMID:17075008^[2]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001736	establishment of planar polarity	FB:FBrf0202014 PMID:18077345^[3]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001736	establishment of planar polarity	FB:FBrf0211889 PMID:20826534^[4]	IGI: Inferred from Genetic Interaction	FB:FBgn0000497	P	From FB
	GO:0001736	establishment of planar polarity	FB:FBrf0211889 PMID:20826534^[4]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001737	establishment of imaginal disc-derived wing hair orientation	FB:FBrf0148937 PMID:12062069^[5]	TAS: Traceable Author Statement		P	From FB
	GO:0001737	establishment of imaginal disc-derived wing hair orientation	FB:FBrf0193425 PMID:16735478^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001737	establishment of imaginal disc-derived wing hair orientation	FB:FBrf0194700 PMID:16687445^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001737	establishment of imaginal disc-derived wing hair orientation	FB:FBrf0211754 PMID:20817616^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0001737	establishment of imaginal disc-derived wing hair orientation	FB:FBrf0213159 PMID:21379328^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0004872	receptor activity	FB:FBrf0129868 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0005509	calcium ion binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR002126 InterPro:IPR015919	F	From FB
	GO:0005886	plasma membrane	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR020894	C	From FB
	GO:0005887	integral to plasma membrane	FB:FBrf0053397 PMID:1959133^[1]	NAS: Non-traceable Author Statement		C	From FB
	GO:0005887	integral to plasma membrane	FB:FBrf0129868 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		C	From FB
	GO:0005887	integral to plasma membrane	FB:FBrf0132105 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		C	From FB
	GO:0007156	homophilic cell adhesion	FB:FBrf0129868 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		P	From FB
	GO:0007156	homophilic cell adhesion	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR002126	P	From FB
	GO:0007164	establishment of tissue polarity	FB:FBrf0155643 PMID:12231350^[11]	NAS: Non-traceable Author Statement		P	From FB
	GO:0007164	establishment of tissue polarity	FB:FBrf0193425 PMID:16735478^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007446	imaginal disc growth	FB:FBrf0058618 PMID:8224829^[12]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007446	imaginal disc growth	FB:FBrf0128473 PMID:10842062^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007446	imaginal disc growth	FB:FBrf0194700 PMID:16687445^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007476	imaginal disc-derived wing morphogenesis	FB:FBrf0194700 PMID:16687445^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008283	cell proliferation	FB:FBrf0053397 PMID:1959133^[1]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008283	cell proliferation	FB:FBrf0128473 PMID:10842062^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008285	negative regulation of cell proliferation	FB:FBrf0194966 PMID:16996265^[14]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016021	integral to membrane	FB:FBrf0128473 PMID:10842062^[13]	TAS: Traceable Author Statement		C	From FB
	GO:0016318	ommatidial rotation	FB:FBrf0148937 PMID:12062069^[5]	TAS: Traceable Author Statement		P	From FB
	GO:0016337	cell-cell adhesion	FB:FBrf0194700 PMID:16687445^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016339	calcium-dependent cell-cell adhesion	FB:FBrf0053397 PMID:1959133^[1]	NAS: Non-traceable Author Statement		P	From FB
	GO:0016339	calcium-dependent cell-cell adhesion	FB:FBrf0129868 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		P	From FB
	GO:0016339	calcium-dependent cell-cell adhesion	FB:FBrf0132105 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		P	From FB
	GO:0016339	calcium-dependent cell-cell adhesion	FB:FBrf0156731	NAS: Non-traceable Author Statement		P	From FB
	GO:0018149	peptide cross-linking	FB:FBrf0081626 PMID:7601355^[15]	IPI: Inferred from Physical Interaction	FB:FBgn0000497	P	From FB
	GO:0030178	negative regulation of Wnt receptor signaling pathway	FB:FBrf0156094 PMID:12414186^[16]	TAS: Traceable Author Statement		P	From FB
	GO:0035159	regulation of tube length, open tracheal system	FB:FBrf0209469 PMID:19956736^[17]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0035329	hippo signaling cascade	FB:FBrf0202014 PMID:18077345^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0011739	P	From FB
	GO:0040008	regulation of growth	FB:FBrf0192304 PMID:17110495^[18]	IGI: Inferred from Genetic Interaction	FB:FBgn0002579	P	From FB
	GO:0040008	regulation of growth	FB:FBrf0192304 PMID:17110495^[18]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0042067	establishment of ommatidial planar polarity	FB:FBrf0146910 PMID:11893338^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0001085	P	From FB
	GO:0042067	establishment of ommatidial planar polarity	FB:FBrf0146910 PMID:11893338^[19]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0042067	establishment of ommatidial planar polarity	FB:FBrf0156198 PMID:12137730^[20]	TAS: Traceable Author Statement		P	From FB
	GO:0042067	establishment of ommatidial planar polarity	FB:FBrf0193425 PMID:16735478^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045198	establishment of epithelial cell apical/basal polarity	FB:FBrf0155499 PMID:12540853^[21]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045317	equator specification	FB:FBrf0145888	NAS: Non-traceable Author Statement		P	From FB
	GO:0045317	equator specification	FB:FBrf0151238 PMID:12123577^[22]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045571	negative regulation of imaginal disc growth	FB:FBrf0141377 PMID:11782950^[23]	TAS: Traceable Author Statement		P	From FB
	GO:0045571	negative regulation of imaginal disc growth	FB:FBrf0213900 PMID:21666802^[24]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045926	negative regulation of growth	FB:FBrf0193425 PMID:16735478^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0046620	regulation of organ growth	FB:FBrf0202014 PMID:18077345^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0011739	P	From FB
	GO:0048105	establishment of body hair planar orientation	FB:FBrf0194700 PMID:16687445^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0050839	cell adhesion molecule binding	FB:FBrf0129868 PMID:10908592^[10]	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0050839	cell adhesion molecule binding	FB:FBrf0179329 PMID:15240556^[25]	IDA: Inferred from Direct Assay		F	From FB
	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	FB:FBrf0211754 PMID:20817616^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Mahoney PA et al. (1991) The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67: 853-68 PubMed GONUTS page
↑ Casal J et al. (2006) Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development 133: 4561-72 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Feng Y & Irvine KD (2007) Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A 104: 20362-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Repiso A et al. (2010) Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat. Development 137: 3411-5 PubMed GONUTS page
↑ ^5.0 ^5.1 Strutt H & Strutt D (2002) Planar polarity: photoreceptors on a high fat diet. Curr Biol 12: R384-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Mao Y et al. (2006) Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133: 2539-51 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Matakatsu H & Blair SS (2006) Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development 133: 2315-24 PubMed GONUTS page
↑ ^8.0 ^8.1 Harumoto T et al. (2010) Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell 19: 389-401 PubMed GONUTS page
↑ Hogan J et al. (2011) Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway. PLoS Genet 7: e1001305 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Hynes RO & Zhao Q (2000) The evolution of cell adhesion. J Cell Biol 150: F89-96 PubMed GONUTS page
↑ Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
↑ Török T et al. (1993) P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. Genetics 135: 71-80 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Garoia F et al. (2000) Cell behaviour of Drosophila fat cadherin mutations in wing development. Mech Dev 94: 95-109 PubMed GONUTS page
↑ Willecke M et al. (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 16: 2090-100 PubMed GONUTS page
↑ Clark HF et al. (1995) Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev 9: 1530-42 PubMed GONUTS page
↑ Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
↑ Chung S et al. (2009) Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet 5: e1000746 PubMed GONUTS page
↑ ^18.0 ^18.1 Tyler DM et al. (2007) Genes affecting cell competition in Drosophila. Genetics 175: 643-57 PubMed GONUTS page
↑ ^19.0 ^19.1 Yang CH et al. (2002) Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108: 675-88 PubMed GONUTS page
↑ Tree DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13: 217-24 PubMed GONUTS page
↑ Ma D et al. (2003) Fidelity in planar cell polarity signalling. Nature 421: 543-7 PubMed GONUTS page
↑ Rawls AS et al. (2002) The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye. Curr Biol 12: 1021-6 PubMed GONUTS page
↑ Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
↑ Rauskolb C et al. (2011) Zyxin links fat signaling to the hippo pathway. PLoS Biol 9: e1000624 PubMed GONUTS page
↑ Matakatsu H & Blair SS (2004) Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131: 3785-94 PubMed GONUTS page

[PMID:1959133-0] 1.0 ^1.1 ^1.2 ^1.3 Mahoney PA et al. (1991) The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67: 853-68 PubMed GONUTS page

[PMID:17075008-1] Casal J et al. (2006) Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development 133: 4561-72 PubMed GONUTS page

[PMID:18077345-2] 3.0 ^3.1 ^3.2 Feng Y & Irvine KD (2007) Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A 104: 20362-7 PubMed GONUTS page

[PMID:20826534-3] 4.0 ^4.1 Repiso A et al. (2010) Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat. Development 137: 3411-5 PubMed GONUTS page

[PMID:12062069-4] 5.0 ^5.1 Strutt H & Strutt D (2002) Planar polarity: photoreceptors on a high fat diet. Curr Biol 12: R384-5 PubMed GONUTS page

[PMID:16735478-5] 6.0 ^6.1 ^6.2 ^6.3 Mao Y et al. (2006) Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133: 2539-51 PubMed GONUTS page

[PMID:16687445-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Matakatsu H & Blair SS (2006) Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development 133: 2315-24 PubMed GONUTS page

[PMID:20817616-7] 8.0 ^8.1 Harumoto T et al. (2010) Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell 19: 389-401 PubMed GONUTS page

[PMID:21379328-8] Hogan J et al. (2011) Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway. PLoS Genet 7: e1001305 PubMed GONUTS page

[PMID:10908592-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Hynes RO & Zhao Q (2000) The evolution of cell adhesion. J Cell Biol 150: F89-96 PubMed GONUTS page

[PMID:12231350-10] Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page

[PMID:8224829-11] Török T et al. (1993) P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. Genetics 135: 71-80 PubMed GONUTS page

[PMID:10842062-12] 13.0 ^13.1 ^13.2 Garoia F et al. (2000) Cell behaviour of Drosophila fat cadherin mutations in wing development. Mech Dev 94: 95-109 PubMed GONUTS page

[PMID:16996265-13] Willecke M et al. (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 16: 2090-100 PubMed GONUTS page

[PMID:7601355-14] Clark HF et al. (1995) Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev 9: 1530-42 PubMed GONUTS page

[PMID:12414186-15] Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page

[PMID:19956736-16] Chung S et al. (2009) Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet 5: e1000746 PubMed GONUTS page

[PMID:17110495-17] 18.0 ^18.1 Tyler DM et al. (2007) Genes affecting cell competition in Drosophila. Genetics 175: 643-57 PubMed GONUTS page

[PMID:11893338-18] 19.0 ^19.1 Yang CH et al. (2002) Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108: 675-88 PubMed GONUTS page

[PMID:12137730-19] Tree DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13: 217-24 PubMed GONUTS page

[PMID:12540853-20] Ma D et al. (2003) Fidelity in planar cell polarity signalling. Nature 421: 543-7 PubMed GONUTS page

[PMID:12123577-21] Rawls AS et al. (2002) The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye. Curr Biol 12: 1021-6 PubMed GONUTS page

[PMID:11782950-22] Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page

[PMID:21666802-23] Rauskolb C et al. (2011) Zyxin links fat signaling to the hippo pathway. PLoS Biol 9: e1000624 PubMed GONUTS page

[PMID:15240556-24] Matakatsu H & Blair SS (2004) Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131: 3785-94 PubMed GONUTS page

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FB:ft

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