FB:fru

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	fru ( synonyms: BTB-VI, BTB-protein-VI, BtbVI, CG14307, CG7688, CG7689, CG7690, CT22773, Dmfru, FRU, Fru, Fruitless, cg7688, cg7689, fru-satori, fruity, fty, ms(3)06411, sat, satori )
Protein Name(s)	fruitless,
External Links
FB	FBgn0004652

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0002118	aggressive behavior	FB:FBrf0201794 PMID:18042702^[1]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0003676	nucleic acid binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	From FB
	GO:0003700	sequence-specific DNA binding transcription factor activity	FB:FBrf0077248 PMID:7938017^[2]	NAS: Non-traceable Author Statement		F	From FB
	GO:0003700	sequence-specific DNA binding transcription factor activity	FB:FBrf0125416 PMID:10648226^[3]	TAS: Traceable Author Statement		F	From FB
	GO:0003700	sequence-specific DNA binding transcription factor activity	FB:FBrf0131304 PMID:11092827^[4]	NAS: Non-traceable Author Statement		F	From FB
	GO:0005622	intracellular	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR007087 InterPro:IPR015880	C	From FB
	GO:0005634	nucleus	FB:FBrf0105495	NAS: Non-traceable Author Statement		C	From FB
	GO:0005634	nucleus	FB:FBrf0116439	NAS: Non-traceable Author Statement		C	From FB
	GO:0005634	nucleus	FB:FBrf0163932	NAS: Non-traceable Author Statement		C	From FB
	GO:0007275	multicellular organismal development	FB:FBrf0091159 PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007417	central nervous system development	FB:FBrf0155804 PMID:12524343^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007417	central nervous system development	FB:FBrf0159373 PMID:12486700^[7]	TAS: Traceable Author Statement		P	From FB
	GO:0007517	muscle organ development	FB:FBrf0091159 PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007517	muscle organ development	FB:FBrf0130128 PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007530	sex determination	FB:FBrf0091159 PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007530	sex determination	FB:FBrf0130128 PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007530	sex determination	FB:FBrf0131304 PMID:11092827^[4]	TAS: Traceable Author Statement		P	From FB
	GO:0007530	sex determination	FB:FBrf0141665 PMID:11715043^[9]	TAS: Traceable Author Statement		P	From FB
	GO:0007617	mating behavior	FB:FBrf0135850 PMID:11291102^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007618	mating	FB:FBrf0064394 PMID:8244010^[11]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007620	copulation	FB:FBrf0146868 PMID:12000098^[12]	TAS: Traceable Author Statement		P	From FB
	GO:0007620	copulation	FB:FBrf0159373 PMID:12486700^[7]	NAS: Non-traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0053825 PMID:1821857^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0064394 PMID:8244010^[11]	TAS: Traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0083021	NAS: Non-traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0128591 PMID:10858821^[14]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0130128 PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0131304 PMID:11092827^[4]	NAS: Non-traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0135681 PMID:11300999^[15]	TAS: Traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0138404 PMID:11514448^[16]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0141665 PMID:11715043^[9]	TAS: Traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0156093 PMID:12350340^[17]	TAS: Traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0159373 PMID:12486700^[7]	NAS: Non-traceable Author Statement		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0188142 PMID:15959468^[18]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0191463 PMID:16179386^[19]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0191584	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008049	male courtship behavior	FB:FBrf0210273 PMID:18167550^[20]	IDA: Inferred from Direct Assay		P	From FB
	GO:0008270	zinc ion binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR007087 InterPro:IPR015880	F	From FB
	GO:0016199	axon midline choice point recognition	FB:FBrf0209580 PMID:20040498^[21]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016543	male courtship behavior, orientation prior to leg tapping and wing vibration	FB:FBrf0146868 PMID:12000098^[12]	NAS: Non-traceable Author Statement		P	From FB
	GO:0016545	male courtship behavior, veined wing vibration	FB:FBrf0049220 PMID:2508613^[22]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045433	male courtship behavior, veined wing generated song production	FB:FBrf0091159 PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045433	male courtship behavior, veined wing generated song production	FB:FBrf0146868 PMID:12000098^[12]	TAS: Traceable Author Statement		P	From FB
	GO:0046661	male sex differentiation	FB:FBrf0159373 PMID:12486700^[7]	TAS: Traceable Author Statement		P	From FB
	GO:0048047	mating behavior, sex discrimination	FB:FBrf0159373 PMID:12486700^[7]	TAS: Traceable Author Statement		P	From FB
	GO:0048047	mating behavior, sex discrimination	FB:FBrf0212145 PMID:20967276^[23]	IGI: Inferred from Genetic Interaction	FB:FBgn0010329	P	From FB
	GO:0048047	mating behavior, sex discrimination	FB:FBrf0212145 PMID:20967276^[23]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0048813	dendrite morphogenesis	FB:FBrf0213400 PMID:21471381^[24]	IMP: Inferred from Mutant Phenotype		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chan YB & Kravitz EA (2007) Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A 104: 19577-82 PubMed GONUTS page
↑ Zollman S et al. (1994) The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A 91: 10717-21 PubMed GONUTS page
↑ Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ryner LC et al. (1996) Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-89 PubMed GONUTS page
↑ Song HJ et al. (2002) The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162: 1703-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Emmons SW & Lipton J (2003) Genetic basis of male sexual behavior. J Neurobiol 54: 93-110 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Usui-Aoki K et al. (2000) Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat Cell Biol 2: 500-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
↑ Lee G et al. (2001) New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J Neurobiol 47: 121-49 PubMed GONUTS page
↑ ^11.0 ^11.1 Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Billeter JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv Genet 47: 87-116 PubMed GONUTS page
↑ Gailey DA et al. (1991) Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development 113: 879-90 PubMed GONUTS page
↑ Nilsson EE et al. (2000) Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. J Neurogenet 13: 213-32 PubMed GONUTS page
↑ Baker BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24 PubMed GONUTS page
↑ Anand A et al. (2001) Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158: 1569-95 PubMed GONUTS page
↑ Christiansen AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet 18: 510-6 PubMed GONUTS page
↑ Manoli DS et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436: 395-400 PubMed GONUTS page
↑ Villella A et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc Natl Acad Sci U S A 102: 16550-7 PubMed GONUTS page
↑ Lee HG et al. (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS One 3: e1391 PubMed GONUTS page
↑ Mellert DJ et al. (2010) Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. Development 137: 323-32 PubMed GONUTS page
↑ Wheeler DA et al. (1989) Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster. Behav Genet 19: 503-28 PubMed GONUTS page
↑ ^23.0 ^23.1 Certel SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS One 5: e13248 PubMed GONUTS page
↑ Goto J et al. (2011) Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J Neurosci 31: 5454-9 PubMed GONUTS page

[PMID:18042702-0] Chan YB & Kravitz EA (2007) Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A 104: 19577-82 PubMed GONUTS page

[PMID:7938017-1] Zollman S et al. (1994) The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A 91: 10717-21 PubMed GONUTS page

[PMID:10648226-2] Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page

[PMID:11092827-3] 4.0 ^4.1 ^4.2 Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page

[PMID:8978612-4] 5.0 ^5.1 ^5.2 ^5.3 Ryner LC et al. (1996) Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-89 PubMed GONUTS page

[PMID:12524343-5] Song HJ et al. (2002) The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162: 1703-24 PubMed GONUTS page

[PMID:12486700-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Emmons SW & Lipton J (2003) Genetic basis of male sexual behavior. J Neurobiol 54: 93-110 PubMed GONUTS page

[PMID:10934470-7] 8.0 ^8.1 ^8.2 Usui-Aoki K et al. (2000) Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat Cell Biol 2: 500-6 PubMed GONUTS page

[PMID:11715043-8] 9.0 ^9.1 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page

[PMID:11291102-9] Lee G et al. (2001) New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J Neurobiol 47: 121-49 PubMed GONUTS page

[PMID:8244010-10] 11.0 ^11.1 Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page

[PMID:12000098-11] 12.0 ^12.1 ^12.2 Billeter JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv Genet 47: 87-116 PubMed GONUTS page

[PMID:1821857-12] Gailey DA et al. (1991) Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development 113: 879-90 PubMed GONUTS page

[PMID:10858821-13] Nilsson EE et al. (2000) Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. J Neurogenet 13: 213-32 PubMed GONUTS page

[PMID:11300999-14] Baker BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24 PubMed GONUTS page

[PMID:11514448-15] Anand A et al. (2001) Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158: 1569-95 PubMed GONUTS page

[PMID:12350340-16] Christiansen AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet 18: 510-6 PubMed GONUTS page

[PMID:15959468-17] Manoli DS et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436: 395-400 PubMed GONUTS page

[PMID:16179386-18] Villella A et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc Natl Acad Sci U S A 102: 16550-7 PubMed GONUTS page

[PMID:18167550-19] Lee HG et al. (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS One 3: e1391 PubMed GONUTS page

[PMID:20040498-20] Mellert DJ et al. (2010) Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. Development 137: 323-32 PubMed GONUTS page

[PMID:2508613-21] Wheeler DA et al. (1989) Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster. Behav Genet 19: 503-28 PubMed GONUTS page

[PMID:20967276-22] 23.0 ^23.1 Certel SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS One 5: e13248 PubMed GONUTS page

[PMID:21471381-23] Goto J et al. (2011) Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J Neurosci 31: 5454-9 PubMed GONUTS page

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FB:fru

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