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FB:foxo
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | foxo ( synonyms: 3143, Afx, CG3143, Dfoxo, DmQ95V5, FKHR, FOXO, Forkhead Box O, Forkhead box, Forkhead box O, Forkhead box type O, FoxO, Foxo, Q95V55, anon-WO0118547.374, cg3143, dFOXO, dFoxO, dFoxo, dfoxo, fd88A, forkhead box sub-group O, forkhead box, subgroup O, forkhead transcription factor ) | |
| Protein Name(s) | forkhead box, sub-group O, | |
| External Links | ||
| FB | FBgn0038197 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0204944 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0001558 |
regulation of cell growth |
FB:FBrf0161481 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001745 |
compound eye morphogenesis |
FB:FBrf0187461 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0212109 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0204944 |
IC: Inferred by Curator |
GO:0001077 |
C |
From FB |
||
| GO:0005737 |
cytoplasm |
FB:FBrf0189901 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005977 |
glycogen metabolic process |
FB:FBrf0195260 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0208272 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0160695 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0161481 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010379 |
P |
From FB |
||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0161481 |
IPI: Inferred from Physical Interaction |
FB:FBgn0013984 |
P |
From FB |
||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0161481 |
IPI: Inferred from Physical Interaction |
FB:FBgn0261560 |
P |
From FB |
||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0179031 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0179222 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009267 |
cellular response to starvation |
FB:FBrf0162177 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009267 |
cellular response to starvation |
FB:FBrf0204944 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009617 |
response to bacterium |
FB:FBrf0195260 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010506 |
regulation of autophagy |
FB:FBrf0194904 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016241 |
regulation of macroautophagy |
FB:FBrf0194904 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0034599 |
cellular response to oxidative stress |
FB:FBrf0162177 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0040008 |
regulation of growth |
FB:FBrf0207166 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0020238 |
P |
From FB |
||
| GO:0040015 |
negative regulation of multicellular organism growth |
FB:FBrf0160695 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0212109 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0160695 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0212109 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010379 |
P |
From FB |
||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0013984 |
P |
From FB |
||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015279 |
P |
From FB |
||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0024248 |
P |
From FB |
||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
FB:FBrf0162177 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026379 |
P |
From FB |
||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
FB:FBrf0179031 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Vihervaara T & Puig O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J Mol Biol 376: 1215-23 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Puig O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-20 PubMed GONUTS page
- ↑ Goberdhan DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132: 2365-75 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Francis VA et al. (2010) dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol 20: 1799-808 PubMed GONUTS page
- ↑ Betschinger J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-53 PubMed GONUTS page
- ↑ 6.0 6.1 Dionne MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 16: 1977-85 PubMed GONUTS page
- ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Kramer JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol 3: 5 PubMed GONUTS page
- ↑ 9.0 9.1 Hwangbo DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429: 562-6 PubMed GONUTS page
- ↑ Giannakou ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 Jünger MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: 20 PubMed GONUTS page
- ↑ 12.0 12.1 Juhász G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ 14: 1181-90 PubMed GONUTS page
- ↑ Nielsen MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7: 688-99 PubMed GONUTS page
