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FB:fkh

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) fkh ( synonyms: CG10002, Dmfkh, FKH, FORK HEAD, Fkh, Fork Head, Fork head, Forkhead, Sebp2, Secretion enhancer-binding protein 2, forkhead )
Protein Name(s) fork head,
External Links
FB FBgn0000659

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0139594
PMID:11598957[1]

TAS: Traceable Author Statement

P

From FB

GO:0001706

endoderm formation

FB:FBrf0147042
PMID:11959838[2]

TAS: Traceable Author Statement

P

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:1347476

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0195124
PMID:16914497[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:1347476

C

From FB

GO:0005634

nucleus

FB:FBrf0123600

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0207774
PMID:19253394[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:1347476

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0123600

NAS: Non-traceable Author Statement

P

From FB

GO:0006916

anti-apoptosis

FB:FBrf0129987
PMID:10976053[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006916

anti-apoptosis

FB:FBrf0159337
PMID:12742168[6]

TAS: Traceable Author Statement

P

From FB

GO:0007431

salivary gland development

FB:FBrf0168046
PMID:14624839[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0007431

salivary gland development

FB:FBrf0187447
PMID:15901661[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007431

salivary gland development

FB:FBrf0214025
PMID:21698206[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0133893

NAS: Non-traceable Author Statement

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0129987
PMID:10976053[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0139594
PMID:11598957[1]

TAS: Traceable Author Statement

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0159337
PMID:12742168[6]

TAS: Traceable Author Statement

P

From FB

GO:0007439

ectodermal digestive tract development

FB:FBrf0111439
PMID:10512197[10]

TAS: Traceable Author Statement

P

From FB

GO:0007443

Malpighian tubule morphogenesis

FB:FBrf0111439
PMID:10512197[10]

TAS: Traceable Author Statement

P

From FB

GO:0007443

Malpighian tubule morphogenesis

FB:FBrf0214025
PMID:21698206[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008134

transcription factor binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR013638

F

From FB

GO:0019904

protein domain specific binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR013638

F

From FB

GO:0030308

negative regulation of cell growth

FB:FBrf0212705
PMID:21217822[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

FB:FBrf0193919
PMID:17339378[12]

IDA: Inferred from Direct Assay

P

From FB

GO:0040015

negative regulation of multicellular organism growth

FB:FBrf0212705
PMID:21217822[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042023

DNA endoreduplication

FB:FBrf0214025
PMID:21698206[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043069

negative regulation of programmed cell death

FB:FBrf0193919
PMID:17339378[12]

IDA: Inferred from Direct Assay

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0195124
PMID:16914497[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0195124
PMID:16914497[3]

IDA: Inferred from Direct Assay

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
  2. Stainier DY (2002) A glimpse into the molecular entrails of endoderm formation. Genes Dev 16: 893-907 PubMed GONUTS page
  3. 3.0 3.1 3.2 Abrams EW et al. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Development 133: 3517-27 PubMed GONUTS page
  4. Jattani R et al. (2009) Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo. Dev Dyn 238: 853-63 PubMed GONUTS page
  5. 5.0 5.1 Myat MM & Andrew DJ (2000) Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development 127: 4217-26 PubMed GONUTS page
  6. 6.0 6.1 Abrams EW et al. (2003) Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol 13: 247-54 PubMed GONUTS page
  7. Nelson WJ (2003) Tube morphogenesis: closure, but many openings remain. Trends Cell Biol 13: 615-21 PubMed GONUTS page
  8. Abrams EW & Andrew DJ (2005) CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Development 132: 2743-58 PubMed GONUTS page
  9. 9.0 9.1 9.2 Maruyama R et al. (2011) Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. PLoS One 6: e20901 PubMed GONUTS page
  10. 10.0 10.1 Murakami R et al. (1999) Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation. Cell Mol Biol (Noisy-le-grand) 45: 661-76 PubMed GONUTS page
  11. 11.0 11.1 Bülow MH et al. (2010) The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PLoS One 5: e15171 PubMed GONUTS page
  12. 12.0 12.1 Cao C et al. (2007) Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J Cell Biol 176: 843-52 PubMed GONUTS page
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