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FB:ey

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) ey ( synonyms: CG1464, DPax-6, EY, EYEL, Ey, Ey/Pax6, Eyeless, Pax-6, Pax6, eye, l(4)102CDh, l(4)102CDr, l(4)33, pax6, tumor-head-63 )
Protein Name(s) eyeless,
External Links
FB FBgn0005558

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001745

compound eye morphogenesis

FB:FBrf0132376
PMID:11153010[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0187515
PMID:15973436[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:97490

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0137174
PMID:11494317[3]

TAS: Traceable Author Statement

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0183930
PMID:15790965[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0206198
PMID:18852455[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0005515

protein binding

FB:FBrf0194852
PMID:17108002[6]

IPI: Inferred from Physical Interaction

FB:FBgn0003460

F

From FB

GO:0005515

protein binding

FB:FBrf0201164
PMID:17493605[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VBW6

F

From FB

GO:0005515

protein binding

FB:FBrf0201164
PMID:17493605[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VBW9

F

From FB

GO:0005634

nucleus

FB:FBrf0128567
PMID:10821764[8]

TAS: Traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0131854

NAS: Non-traceable Author Statement

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:97490

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:97490

P

From FB

GO:0007420

brain development

FB:FBrf0132376
PMID:11153010[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007455

eye-antennal disc morphogenesis

FB:FBrf0128567
PMID:10821764[8]

TAS: Traceable Author Statement

P

From FB

GO:0007628

adult walking behavior

FB:FBrf0132376
PMID:11153010[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008347

glial cell migration

FB:FBrf0145174
PMID:11804568[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016319

mushroom body development

FB:FBrf0128595
PMID:10903173[10]

IEP: Inferred from Expression Pattern

P

From FB

GO:0016319

mushroom body development

FB:FBrf0128595
PMID:10903173[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016319

mushroom body development

FB:FBrf0132376
PMID:11153010[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016319

mushroom body development

FB:FBrf0209021
PMID:19666017[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016319

mushroom body development

FB:FBrf0209574
PMID:19901536[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030182

neuron differentiation

FB:FBrf0206198
PMID:18852455[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040018

positive regulation of multicellular organism growth

FB:FBrf0206198
PMID:18852455[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0194852
PMID:17108002[6]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0043567

regulation of insulin-like growth factor receptor signaling pathway

FB:FBrf0206198
PMID:18852455[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043704

photoreceptor cell fate specification

FB:FBrf0193889
PMID:16780828[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0206198
PMID:18852455[5]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0183930
PMID:15790965[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0187515
PMID:15973436[2]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0206198
PMID:18852455[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048036

central complex development

FB:FBrf0209021
PMID:19666017[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048749

compound eye development

FB:FBrf0131854

NAS: Non-traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0145168
PMID:11875444[14]

TAS: Traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0209021
PMID:19666017[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048854

brain morphogenesis

FB:FBrf0209574
PMID:19901536[12]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Callaerts P et al. (2001) Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. J Neurobiol 46: 73-88 PubMed GONUTS page
  2. 2.0 2.1 Yao JG & Sun YH (2005) Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development. EMBO J 24: 2602-12 PubMed GONUTS page
  3. Gibson MC & Schubiger G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23: 691-7 PubMed GONUTS page
  4. 4.0 4.1 Blanco J et al. (2005) Functional analysis of the chicken delta1-crystallin enhancer activity in Drosophila reveals remarkable evolutionary conservation between chicken and fly. Development 132: 1895-905 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Clements J et al. (2008) Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons. Proc Natl Acad Sci U S A 105: 16183-8 PubMed GONUTS page
  6. 6.0 6.1 Zhang T et al. (2006) Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. Development 133: 4881-9 PubMed GONUTS page
  7. 7.0 7.1 Curtiss J et al. (2007) distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. Dev Biol 306: 685-702 PubMed GONUTS page
  8. 8.0 8.1 Martini SR et al. (2000) The retinal determination gene, dachshund, is required for mushroom body cell differentiation. Development 127: 2663-72 PubMed GONUTS page
  9. Hummel T et al. (2002) Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron 33: 193-203 PubMed GONUTS page
  10. 10.0 10.1 Noveen A et al. (2000) Early development of the Drosophila mushroom body: the roles of eyeless and dachshund. Development 127: 3475-88 PubMed GONUTS page
  11. 11.0 11.1 11.2 Clements J et al. (2009) Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Dev Biol 334: 503-12 PubMed GONUTS page
  12. 12.0 12.1 Furukubo-Tokunaga K et al. (2009) Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster. Fly (Austin) 3: 263-9 PubMed GONUTS page
  13. Anderson J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev Biol 297: 536-49 PubMed GONUTS page
  14. Curtiss J et al. (2002) Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol 4: E48-51 PubMed GONUTS page
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