![]()
GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:exd
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | exd ( synonyms: CG8933, DExd, Dm-EXD, Dpbx, EXD, Exd, Extradenticle, Homothorax, Pbx1, Pbx1-oncogene-like, anon-EST:fe1H3, anon-fast-evolving-1H3, l(1)IV, td48 ) | |
| Protein Name(s) | extradenticle, | |
| External Links | ||
| FB | FBgn0000611 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
FB:FBrf0107928 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0190166 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0141189 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0106039 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0205665 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003713 |
transcription coactivator activity |
FB:FBrf0106039 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0098877 |
IPI: Inferred from Physical Interaction |
FB:FBgn0001235 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0107928 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0107928 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0098877 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0099948 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0104896 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0141189 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005667 |
transcription factor complex |
FB:FBrf0205665 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000014 |
C |
From FB |
||
| GO:0005667 |
transcription factor complex |
FB:FBrf0205665 |
IPI: Inferred from Physical Interaction |
FB:FBgn0001235 |
C |
From FB |
||
| GO:0005737 |
cytoplasm |
FB:FBrf0098877 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0099948 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0104896 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0007420 |
brain development |
FB:FBrf0128584 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0139594 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0159337 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0168046 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007438 |
oenocyte development |
FB:FBrf0148967 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007479 |
leg disc proximal/distal pattern formation |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008134 |
transcription factor binding |
FB:FBrf0211269 |
IPI: Inferred from Physical Interaction |
FB:FBgn0001235 |
F |
From FB |
||
| GO:0033613 |
activating transcription factor binding |
FB:FBrf0106039 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000439 |
F |
From FB |
||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0213960 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0100049 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0211269 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0100049 |
IPI: Inferred from Physical Interaction |
FB:FBgn0002522 |
F |
From FB |
||
|
contributes_to |
GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0100049 |
IPI: Inferred from Physical Interaction |
FB:FBgn0002522 |
F |
From FB |
|
|
contributes_to |
GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0211269 |
IPI: Inferred from Physical Interaction |
FB:FBgn0001235 |
F |
From FB |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Passner JM et al. (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397: 714-9 PubMed GONUTS page
- ↑ Stultz BG et al. (2006) Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol 290: 482-94 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Li X et al. (1999) Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J 18: 198-211 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Li-Kroeger D et al. (2008) Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev Cell 15: 298-308 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Rieckhof GE et al. (1997) Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell 91: 171-83 PubMed GONUTS page
- ↑ 6.0 6.1 Azpiazu N & Morata G (1998) Functional and regulatory interactions between Hox and extradenticle genes. Genes Dev 12: 261-73 PubMed GONUTS page
- ↑ 7.0 7.1 Abu-Shaar M & Mann RS (1998) Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125: 3821-30 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Marsh JL & Theisen H (1999) Regeneration in insects. Semin Cell Dev Biol 10: 365-75 PubMed GONUTS page
- ↑ Nagao T et al. (2000) Patterning defects in the primary axonal scaffolds caused by the mutations of the extradenticle and homothorax genes in the embryonic Drosophila brain. Dev Genes Evol 210: 289-99 PubMed GONUTS page
- ↑ Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
- ↑ Abrams EW et al. (2003) Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol 13: 247-54 PubMed GONUTS page
- ↑ Nelson WJ (2003) Tube morphogenesis: closure, but many openings remain. Trends Cell Biol 13: 615-21 PubMed GONUTS page
- ↑ Brodu V et al. (2002) abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129: 2957-63 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Joshi R et al. (2010) Dissecting the functional specificities of two Hox proteins. Genes Dev 24: 1533-45 PubMed GONUTS page
- ↑ Ahn Y et al. (2011) Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development. Dev Biol 355: 336-48 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Grieder NC et al. (1997) Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J 16: 7402-10 PubMed GONUTS page