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FB:exd

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) exd ( synonyms: CG8933, DExd, Dm-EXD, Dpbx, EXD, Exd, Extradenticle, Homothorax, Pbx1, Pbx1-oncogene-like, anon-EST:fe1H3, anon-fast-evolving-1H3, l(1)IV, td48 )
Protein Name(s) extradenticle,
External Links
FB FBgn0000611

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

FB:FBrf0107928
PMID:10067897[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003677

DNA binding

FB:FBrf0190166
PMID:16403493[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0141189

NAS: Non-traceable Author Statement

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0106039
PMID:9878063[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0205665
PMID:18694568[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003713

transcription coactivator activity

FB:FBrf0106039
PMID:9878063[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0005515

protein binding

FB:FBrf0098877
PMID:9346235[5]

IPI: Inferred from Physical Interaction

FB:FBgn0001235

F

From FB

GO:0005515

protein binding

FB:FBrf0107928
PMID:10067897[1]

IPI: Inferred from Physical Interaction

UniProtKB:P02834

F

From FB

GO:0005515

protein binding

FB:FBrf0107928
PMID:10067897[1]

IPI: Inferred from Physical Interaction

UniProtKB:P83949

F

From FB

GO:0005634

nucleus

FB:FBrf0098877
PMID:9346235[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0099948
PMID:9436985[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0104896
PMID:9729490[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0111421
PMID:10497093[8]

TAS: Traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0141189

NAS: Non-traceable Author Statement

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0205665
PMID:18694568[4]

IPI: Inferred from Physical Interaction

FB:FBgn0000014

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0205665
PMID:18694568[4]

IPI: Inferred from Physical Interaction

FB:FBgn0001235

C

From FB

GO:0005737

cytoplasm

FB:FBrf0098877
PMID:9346235[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0099948
PMID:9436985[6]

TAS: Traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0104896
PMID:9729490[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0111421
PMID:10497093[8]

TAS: Traceable Author Statement

C

From FB

GO:0007420

brain development

FB:FBrf0128584
PMID:11180834[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0139594
PMID:11598957[10]

TAS: Traceable Author Statement

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0159337
PMID:12742168[11]

TAS: Traceable Author Statement

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0168046
PMID:14624839[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0007438

oenocyte development

FB:FBrf0148967
PMID:12050142[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007479

leg disc proximal/distal pattern formation

FB:FBrf0111421
PMID:10497093[8]

TAS: Traceable Author Statement

P

From FB

GO:0008134

transcription factor binding

FB:FBrf0211269
PMID:20634319[14]

IPI: Inferred from Physical Interaction

FB:FBgn0001235

F

From FB

GO:0033613

activating transcription factor binding

FB:FBrf0106039
PMID:9878063[3]

IPI: Inferred from Physical Interaction

FB:FBgn0000439

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0213960
PMID:21575621[15]

IDA: Inferred from Direct Assay

F

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0100049
PMID:9405369[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0211269
PMID:20634319[14]

IDA: Inferred from Direct Assay

P

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0100049
PMID:9405369[16]

IPI: Inferred from Physical Interaction

FB:FBgn0002522

F

From FB

contributes_to

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0100049
PMID:9405369[16]

IPI: Inferred from Physical Interaction

FB:FBgn0002522

F

From FB

contributes_to

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0211269
PMID:20634319[14]

IPI: Inferred from Physical Interaction

FB:FBgn0001235

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Passner JM et al. (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397: 714-9 PubMed GONUTS page
  2. Stultz BG et al. (2006) Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol 290: 482-94 PubMed GONUTS page
  3. 3.0 3.1 3.2 Li X et al. (1999) Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J 18: 198-211 PubMed GONUTS page
  4. 4.0 4.1 4.2 Li-Kroeger D et al. (2008) Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev Cell 15: 298-308 PubMed GONUTS page
  5. 5.0 5.1 5.2 Rieckhof GE et al. (1997) Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell 91: 171-83 PubMed GONUTS page
  6. 6.0 6.1 Azpiazu N & Morata G (1998) Functional and regulatory interactions between Hox and extradenticle genes. Genes Dev 12: 261-73 PubMed GONUTS page
  7. 7.0 7.1 Abu-Shaar M & Mann RS (1998) Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125: 3821-30 PubMed GONUTS page
  8. 8.0 8.1 8.2 Marsh JL & Theisen H (1999) Regeneration in insects. Semin Cell Dev Biol 10: 365-75 PubMed GONUTS page
  9. Nagao T et al. (2000) Patterning defects in the primary axonal scaffolds caused by the mutations of the extradenticle and homothorax genes in the embryonic Drosophila brain. Dev Genes Evol 210: 289-99 PubMed GONUTS page
  10. Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
  11. Abrams EW et al. (2003) Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol 13: 247-54 PubMed GONUTS page
  12. Nelson WJ (2003) Tube morphogenesis: closure, but many openings remain. Trends Cell Biol 13: 615-21 PubMed GONUTS page
  13. Brodu V et al. (2002) abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129: 2957-63 PubMed GONUTS page
  14. 14.0 14.1 14.2 Joshi R et al. (2010) Dissecting the functional specificities of two Hox proteins. Genes Dev 24: 1533-45 PubMed GONUTS page
  15. Ahn Y et al. (2011) Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development. Dev Biol 355: 336-48 PubMed GONUTS page
  16. 16.0 16.1 16.2 Grieder NC et al. (1997) Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J 16: 7402-10 PubMed GONUTS page
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