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FB:ex
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | ex ( synonyms: 1270, CG4114, Ex, Expanded, braille, brl, l(2)01270, l(2)ey ) | |
| Protein Name(s) | expanded, | |
| External Links | ||
| FB | FBgn0004583 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001745 |
compound eye morphogenesis |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001745 |
compound eye morphogenesis |
FB:FBrf0211036 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0259685 |
P |
From FB |
||
| GO:0001751 |
compound eye photoreceptor cell differentiation |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0001751 |
compound eye photoreceptor cell differentiation |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0125175 |
IPI: Inferred from Physical Interaction |
FB:FBgn0086384 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0210017 |
IPI: Inferred from Physical Interaction |
FB:FBgn0261456 |
F |
From FB |
||
| GO:0005856 |
cytoskeleton |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0005915 |
zonula adherens |
FB:FBrf0159315 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0007050 |
cell cycle arrest |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0007096 |
regulation of exit from mitosis |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0156820 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007444 |
imaginal disc development |
FB:FBrf0156820 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008101 |
decapentaplegic signaling pathway |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000490 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0125175 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009966 |
regulation of signal transduction |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0125175 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0141377 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0032456 |
endocytic recycling |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0035329 |
hippo signaling cascade |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261456 |
P |
From FB |
||
| GO:0035329 |
hippo signaling cascade |
FB:FBrf0202014 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011739 |
P |
From FB |
||
| GO:0035331 |
negative regulation of hippo signaling cascade |
FB:FBrf0207465 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011739 |
P |
From FB |
||
| GO:0035331 |
negative regulation of hippo signaling cascade |
FB:FBrf0207465 |
IPI: Inferred from Physical Interaction |
FB:FBgn0034970 |
P |
From FB |
||
| GO:0040008 |
regulation of growth |
FB:FBrf0192304 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002579 |
P |
From FB |
||
| GO:0040008 |
regulation of growth |
FB:FBrf0207465 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0156820 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0042327 |
positive regulation of phosphorylation |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0042981 |
regulation of apoptotic process |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0045571 |
negative regulation of imaginal disc growth |
FB:FBrf0141377 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045571 |
negative regulation of imaginal disc growth |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011739 |
P |
From FB |
||
| GO:0045571 |
negative regulation of imaginal disc growth |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045571 |
negative regulation of imaginal disc growth |
FB:FBrf0213900 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045595 |
regulation of cell differentiation |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0046620 |
regulation of organ growth |
FB:FBrf0202014 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011739 |
P |
From FB |
||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086384 |
P |
From FB |
||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Pellock BJ et al. (2007) The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol 304: 102-15 PubMed GONUTS page
- ↑ Ling C et al. (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A 107: 10532-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Maitra S et al. (2006) The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol 16: 702-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 McCartney BM et al. (2000) The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127: 1315-24 PubMed GONUTS page
- ↑ Yu J et al. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18: 288-99 PubMed GONUTS page
- ↑ Cereijido M et al. (2003) Membrane targeting. Prog Biophys Mol Biol 81: 81-115 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Hamaratoglu F et al. (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8: 27-36 PubMed GONUTS page
- ↑ 8.0 8.1 Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ 9.0 9.1 Feng Y & Irvine KD (2007) Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A 104: 20362-7 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Badouel C et al. (2009) The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell 16: 411-20 PubMed GONUTS page
- ↑ Tyler DM et al. (2007) Genes affecting cell competition in Drosophila. Genetics 175: 643-57 PubMed GONUTS page
- ↑ Rauskolb C et al. (2011) Zyxin links fat signaling to the hippo pathway. PLoS Biol 9: e1000624 PubMed GONUTS page
