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FB:e

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) e ( synonyms: CG3331, Ebony, NBAD-synthase )
Protein Name(s) ebony,
External Links
FB FBgn0000527

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000036

acyl carrier activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR009081

F

From FB

GO:0001692

histamine metabolic process

FB:FBrf0155892
PMID:12486147[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003833

beta-alanyl-dopamine synthase activity

FB:FBrf0086102
PMID:8580497[2]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0003833

beta-alanyl-dopamine synthase activity

FB:FBrf0162298
PMID:12957543[3]

TAS: Traceable Author Statement

F

From FB

GO:0003833

beta-alanyl-dopamine synthase activity

FB:FBrf0178947
PMID:12900414[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003833

beta-alanyl-dopamine synthase activity

FB:FBrf0209498
PMID:19715698[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0005737

cytoplasm

FB:FBrf0209498
PMID:19715698[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006583

melanin biosynthetic process from tyrosine

FB:FBrf0162298
PMID:12957543[3]

TAS: Traceable Author Statement

P

From FB

GO:0007593

chitin-based cuticle tanning

FB:FBrf0086102
PMID:8580497[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007623

circadian rhythm

FB:FBrf0141665
PMID:11715043[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0042417

dopamine metabolic process

FB:FBrf0178947
PMID:12900414[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0042440

pigment metabolic process

FB:FBrf0151319
PMID:12119094[7]

TAS: Traceable Author Statement

P

From FB

GO:0043042

amino acid adenylylation by nonribosomal peptide synthase

FB:FBrf0178947
PMID:12900414[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0045475

locomotor rhythm

FB:FBrf0141665
PMID:11715043[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0048022

negative regulation of melanin biosynthetic process

FB:FBrf0146983
PMID:11934851[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048037

cofactor binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR006163

F

From FB

GO:0048066

developmental pigmentation

FB:FBrf0162298
PMID:12957543[3]

TAS: Traceable Author Statement

P

From FB

GO:0048067

cuticle pigmentation

FB:FBrf0146983
PMID:11934851[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0004034

P

From FB

GO:0048067

cuticle pigmentation

FB:FBrf0146983
PMID:11934851[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048082

regulation of adult chitin-containing cuticle pigmentation

FB:FBrf0209558
PMID:20019281[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048082

regulation of adult chitin-containing cuticle pigmentation

FB:FBrf0215011
PMID:21878507[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0014006

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Borycz J et al. (2002) tan and ebony genes regulate a novel pathway for transmitter metabolism at fly photoreceptor terminals. J Neurosci 22: 10549-57 PubMed GONUTS page
  2. 2.0 2.1 Walter MF et al. (1996) Catecholamine metabolism and in vitro induction of premature cuticle melanization in wild type and pigmentation mutants of Drosophila melanogaster. Arch Insect Biochem Physiol 31: 219-33 PubMed GONUTS page
  3. 3.0 3.1 3.2 Wittkopp PJ et al. (2003) Evolution in black and white: genetic control of pigment patterns in Drosophila. Trends Genet 19: 495-504 PubMed GONUTS page
  4. 4.0 4.1 4.2 Richardt A et al. (2003) Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J Biol Chem 278: 41160-6 PubMed GONUTS page
  5. 5.0 5.1 Pérez MM et al. (2010) The enzyme NBAD-synthase plays diverse roles during the life cycle of Drosophila melanogaster. J Insect Physiol 56: 8-13 PubMed GONUTS page
  6. 6.0 6.1 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
  7. Calleja M et al. (2002) How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292: 1-12 PubMed GONUTS page
  8. 8.0 8.1 8.2 Wittkopp PJ et al. (2002) Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patterns. Development 129: 1849-58 PubMed GONUTS page
  9. Rebeiz M et al. (2009) Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population. Science 326: 1663-7 PubMed GONUTS page
  10. Sekine Y et al. (2011) p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J Cell Sci 124: 3006-16 PubMed GONUTS page
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