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FB:dlg1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | dlg1 ( synonyms: 11, CG1725, CG1730, CPD, DLG, DLG-A, Disc Large, Disc large, Disc-large, Discs Large, Discs large, Discs large 1, Discs-Large, Discs-large, Discslarge, Disk Large, Dlg, Dlg-A, Dlg1, DlgA, Drodlg, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, disc large, disc-large, discs large, discs-large, discslarge, dlg, dlg-1, dlg-A, dlgA, dlgS97, l(1)10Bf, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)L11, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)l.pr.-2, l(1)lpr-2, lethal(1)benign wing imaginal disc neoplasm, lethal(1)discs large, lethal(1)discs-large, lethal(2)discs large, misb ) | |
| Protein Name(s) | discs large 1, | |
| External Links | ||
| FB | FBgn0001624 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001738 |
morphogenesis of a polarized epithelium |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0002009 |
morphogenesis of an epithelium |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0004385 |
guanylate kinase activity |
FB:FBrf0111569 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004385 |
guanylate kinase activity |
FB:FBrf0132417 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005154 |
epidermal growth factor receptor binding |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005198 |
structural molecule activity |
FB:FBrf0137174 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0146937 |
IPI: Inferred from Physical Interaction |
FB:FBgn0026239 |
F |
From FB |
||
| GO:0005856 |
cytoskeleton |
FB:FBrf0123962 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0105495 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0167940 |
IMP: Inferred from Mutant Phenotype |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0210975 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0141282 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0151280 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0155581 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0157330 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0159315 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0132417 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0007010 |
cytoskeleton organization |
FB:FBrf0157330 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007268 |
synaptic transmission |
FB:FBrf0111569 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007268 |
synaptic transmission |
FB:FBrf0152140 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007399 |
nervous system development |
FB:FBrf0132417 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007617 |
mating behavior |
FB:FBrf0202247 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008049 |
male courtship behavior |
FB:FBrf0202247 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0146937 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0167435 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008105 |
asymmetric protein localization |
FB:FBrf0132417 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008105 |
asymmetric protein localization |
FB:FBrf0155643 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008105 |
asymmetric protein localization |
FB:FBrf0155996 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0128403 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0111569 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016323 |
basolateral plasma membrane |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016327 |
apicolateral plasma membrane |
FB:FBrf0128403 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016328 |
lateral plasma membrane |
FB:FBrf0215852 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
FB:FBrf0132417 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
FB:FBrf0132418 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016333 |
morphogenesis of follicular epithelium |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016334 |
establishment or maintenance of polarity of follicular epithelium |
FB:FBrf0128403 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002121 |
P |
From FB |
||
| GO:0016335 |
morphogenesis of larval imaginal disc epithelium |
FB:FBrf0128403 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016336 |
establishment or maintenance of polarity of larval imaginal disc epithelium |
FB:FBrf0128403 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016336 |
establishment or maintenance of polarity of larval imaginal disc epithelium |
FB:FBrf0141282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0019991 |
septate junction assembly |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0019991 |
septate junction assembly |
FB:FBrf0157330 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030710 |
regulation of border follicle cell delamination |
FB:FBrf0128450 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0031594 |
neuromuscular junction |
FB:FBrf0201824 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0157330 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043195 |
terminal button |
FB:FBrf0146937 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045167 |
asymmetric protein localization involved in cell fate determination |
FB:FBrf0174511 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045175 |
basal protein localization |
FB:FBrf0132418 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045175 |
basal protein localization |
FB:FBrf0156163 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0132418 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0189924 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045196 |
establishment or maintenance of neuroblast polarity |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0141377 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045202 |
synapse |
FB:FBrf0167435 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0045202 |
synapse |
FB:FBrf0192396 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045211 |
postsynaptic membrane |
FB:FBrf0189896 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045475 |
locomotor rhythm |
FB:FBrf0202247 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046956 |
positive phototaxis |
FB:FBrf0202247 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
FB:FBrf0215852 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0051124 |
synaptic growth at neuromuscular junction |
FB:FBrf0192396 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051294 |
establishment of spindle orientation |
FB:FBrf0189924 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0159915 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
|
colocalizes_with |
GO:0042734 |
presynaptic membrane |
FB:FBrf0146937 |
IDA: Inferred from Direct Assay |
C |
From FB |
||
|
colocalizes_with |
GO:0045211 |
postsynaptic membrane |
FB:FBrf0201824 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gibson MC & Perrimon N (2003) Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol 15: 747-52 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Koh YH et al. (1999) Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell 98: 353-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Ohshiro T et al. (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
- ↑ Gibson MC & Schubiger G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23: 691-7 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Mathew D et al. (2002) Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol 12: 531-9 PubMed GONUTS page
- ↑ Lee OK et al. (2003) Discs-Large and Strabismus are functionally linked to plasma membrane formation. Nat Cell Biol 5: 987-93 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ Médina E et al. (2002) Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell 94: 305-13 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Caruana G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int J Dev Biol 46: 511-8 PubMed GONUTS page
- ↑ Cereijido M et al. (2003) Membrane targeting. Prog Biophys Mol Biol 81: 81-115 PubMed GONUTS page
- ↑ Karunanithi S et al. (2002) Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses. J Neurosci 22: 10267-76 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Mendoza-Topaz C et al. (2008) DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function. J Neurosci 28: 304-14 PubMed GONUTS page
- ↑ 16.0 16.1 Packard M et al. (2003) FASt remodeling of synapses in Drosophila. Curr Opin Neurobiol 13: 527-34 PubMed GONUTS page
- ↑ Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
- ↑ Albertson R & Doe CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5: 166-70 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 19.4 19.5 Bilder D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-6 PubMed GONUTS page
- ↑ 20.0 20.1 Albornoz V et al. (2008) Temporal and spatial expression of Drosophila DLGS97 during neural development. Gene Expr Patterns 8: 443-51 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Peng CY et al. (2000) The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600 PubMed GONUTS page
- ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
- ↑ 23.0 23.1 Kohsaka H et al. (2007) In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J Cell Biol 179: 1289-300 PubMed GONUTS page
- ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
- ↑ Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
- ↑ 26.0 26.1 Siegrist SE & Doe CQ (2005) Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell 123: 1323-35 PubMed GONUTS page
- ↑ Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ 28.0 28.1 Zhang Y et al. (2007) PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction. Neuron 53: 201-15 PubMed GONUTS page
- ↑ Ashraf SI et al. (2006) Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 124: 191-205 PubMed GONUTS page
