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FB:dl

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) dl ( synonyms: CG6667, DL, Dl, Dor, Dorsal, Embryonic polarity protein dorsal, GSd447, NFkappaB, anon-EST:GressD7, d;, dL, fs(2)k10816, mat(2)dorsal )
Protein Name(s) dorsal,
External Links
FB FBgn0260632

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0141281
PMID:11700289[1]

TAS: Traceable Author Statement

P

From FB

GO:0000381

regulation of alternative nuclear mRNA splicing, via spliceosome

FB:FBrf0180650
PMID:15492211[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0053372
PMID:1988156[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0105336
PMID:9774673[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0106026
PMID:9806924[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

FB:FBrf0053349
PMID:1648449[6]

IDA: Inferred from Direct Assay

F

From FB

GO:0001715

ectodermal cell fate specification

FB:FBrf0128774
PMID:10878576[7]

TAS: Traceable Author Statement

P

From FB

GO:0003677

DNA binding

FB:FBrf0123611

NAS: Non-traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:97897

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0133282

NAS: Non-traceable Author Statement

F

From FB

GO:0005515

protein binding

FB:FBrf0125338
PMID:10660560[8]

IPI: Inferred from Physical Interaction

FB:FBgn0010602

F

From FB

GO:0005515

protein binding

FB:FBrf0125338
PMID:10660560[8]

IPI: Inferred from Physical Interaction

FB:FBgn0026170

F

From FB

GO:0005515

protein binding

FB:FBrf0125338
PMID:10660560[8]

IPI: Inferred from Physical Interaction

FB:FBgn0040465

F

From FB

GO:0005515

protein binding

FB:FBrf0158946
PMID:12653959[9]

IPI: Inferred from Physical Interaction

FB:FBgn0041582

F

From FB

GO:0005634

nucleus

FB:FBrf0100747
PMID:9510254[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

IC: Inferred by Curator

GO:0003700

C

From FB

GO:0005634

nucleus

FB:FBrf0110270
PMID:10369678[11]

TAS: Traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0110978
PMID:10449356[12]

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0123611

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0127230
PMID:10793472[13]

TAS: Traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0141281
PMID:11700289[1]

TAS: Traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0147014
PMID:11943764[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0155963
PMID:12556495[15]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0180650
PMID:15492211[2]

IC: Inferred by Curator

GO:0000381

C

From FB

GO:0005737

cytoplasm

FB:FBrf0100747
PMID:9510254[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0110270
PMID:10369678[11]

TAS: Traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0123611

NAS: Non-traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0127230
PMID:10793472[13]

TAS: Traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0141281
PMID:11700289[1]

TAS: Traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0147014
PMID:11943764[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:97897

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0148941
PMID:12027434[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0006952

defense response

FB:FBrf0099002
PMID:9321392[17]

TAS: Traceable Author Statement

P

From FB

GO:0006952

defense response

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0006955

immune response

FB:FBrf0080205
PMID:7859742[18]

IEP: Inferred from Expression Pattern

P

From FB

GO:0006955

immune response

FB:FBrf0123611

NAS: Non-traceable Author Statement

P

From FB

GO:0006955

immune response

FB:FBrf0128774
PMID:10878576[7]

TAS: Traceable Author Statement

P

From FB

GO:0007369

gastrulation

FB:FBrf0110176
PMID:10369659[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0007398

ectoderm development

FB:FBrf0148941
PMID:12027434[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0007419

ventral cord development

FB:FBrf0148941
PMID:12027434[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0148941
PMID:12027434[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0007501

mesodermal cell fate specification

FB:FBrf0128774
PMID:10878576[7]

TAS: Traceable Author Statement

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[20]

NAS: Non-traceable Author Statement

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0141068
PMID:11283698[21]

TAS: Traceable Author Statement

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0155688
PMID:12530956[22]

TAS: Traceable Author Statement

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0179043
PMID:15199954[23]

TAS: Traceable Author Statement

P

From FB

GO:0008354

germ cell migration

FB:FBrf0107500
PMID:9988212[24]

TAS: Traceable Author Statement

P

From FB

GO:0008358

maternal determination of anterior/posterior axis, embryo

FB:FBrf0065633

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0127230
PMID:10793472[13]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0141281
PMID:11700289[1]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0159908
PMID:12217523[25]

TAS: Traceable Author Statement

P

From FB

GO:0009952

anterior/posterior pattern specification

FB:FBrf0107500
PMID:9988212[24]

TAS: Traceable Author Statement

P

From FB

GO:0009953

dorsal/ventral pattern formation

FB:FBrf0128774
PMID:10878576[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0010004

gastrulation involving germ band extension

FB:FBrf0179905
PMID:15380237[26]

TAS: Traceable Author Statement

P

From FB

GO:0010629

negative regulation of gene expression

FB:FBrf0193889
PMID:16780828[27]

IDA: Inferred from Direct Assay

P

From FB

GO:0016015

morphogen activity

FB:FBrf0123611

NAS: Non-traceable Author Statement

F

From FB

GO:0031594

neuromuscular junction

FB:FBrf0155887
PMID:12532402[28]

IDA: Inferred from Direct Assay

C

From FB

GO:0035006

melanization defense response

FB:FBrf0179135
PMID:15211580[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035206

regulation of hemocyte proliferation

FB:FBrf0193396
PMID:17060622[30]

IDA: Inferred from Direct Assay

P

From FB

GO:0042387

plasmatocyte differentiation

FB:FBrf0187386
PMID:15882582[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0201799
PMID:17785540[32]

IDA: Inferred from Direct Assay

F

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0141797
PMID:11691830[33]

TAS: Traceable Author Statement

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0148941
PMID:12027434[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0141797
PMID:11691830[33]

TAS: Traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0106026
PMID:9806924[5]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0151249
PMID:12027431[20]

TAS: Traceable Author Statement

P

From FB

GO:0048935

peripheral nervous system neuron development

FB:FBrf0210269
PMID:18000549[34]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0070379

high mobility group box 1 binding

FB:FBrf0127514
PMID:10606643[35]

IPI: Inferred from Physical Interaction

FB:FBgn0011764

F

From FB

GO:0070491

repressing transcription factor binding

FB:FBrf0105336
PMID:9774673[4]

IPI: Inferred from Physical Interaction

FB:FBgn0001139

F

From FB

GO:0070491

repressing transcription factor binding

FB:FBrf0127514
PMID:10606643[35]

IPI: Inferred from Physical Interaction

FB:FBgn0011764

F

From FB

contributes_to

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0155780
PMID:12459265[36]

IGI: Inferred from Genetic Interaction

FB:FBgn0003900

F

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
  2. ↑ 2.0 2.1 Park JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A 101: 15974-9 PubMed GONUTS page
  3. ↑ Ip YT et al. (1991) The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Cell 64: 439-46 PubMed GONUTS page
  4. ↑ 4.0 4.1 Valentine SA et al. (1998) Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer. Mol Cell Biol 18: 6584-94 PubMed GONUTS page
  5. ↑ 5.0 5.1 Benveniste RJ et al. (1998) Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125: 4757-65 PubMed GONUTS page
  6. ↑ Thisse C et al. (1991) Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell 65: 1191-201 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Bhaskar V et al. (2000) A functional interaction between dorsal and components of the Smt3 conjugation machinery. J Biol Chem 275: 4033-40 PubMed GONUTS page
  9. ↑ Minakhina S et al. (2003) Tamo selectively modulates nuclear import in Drosophila. Genes Cells 8: 299-310 PubMed GONUTS page
  10. ↑ 10.0 10.1 Wu LP & Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 392: 93-7 PubMed GONUTS page
  11. ↑ 11.0 11.1 Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page
  12. ↑ van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page
  14. ↑ 14.0 14.1 Bhattacharya A & Steward R (2002) The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response. EMBO Rep 3: 378-83 PubMed GONUTS page
  15. ↑ Park JM et al. (2003) Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 23: 1358-67 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 16.3 16.4 Stathopoulos A & Levine M (2002) Dorsal gradient networks in the Drosophila embryo. Dev Biol 246: 57-67 PubMed GONUTS page
  17. ↑ Williams MJ et al. (1997) The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J 16: 6120-30 PubMed GONUTS page
  18. ↑ Lemaitre B et al. (1995) Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J 14: 536-45 PubMed GONUTS page
  19. ↑ Leptin M (1999) Gastrulation in Drosophila: the logic and the cellular mechanisms. EMBO J 18: 3187-92 PubMed GONUTS page
  20. ↑ 20.0 20.1 Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  21. ↑ Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
  22. ↑ Silverman N (2003) Flies kNOw how to signal. Dev Cell 4: 5-6 PubMed GONUTS page
  23. ↑ Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
  24. ↑ 24.0 24.1 Wylie C (1999) Germ cells. Cell 96: 165-74 PubMed GONUTS page
  25. ↑ Janssens S & Beyaert R (2002) A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci 27: 474-82 PubMed GONUTS page
  26. ↑ Stathopoulos A & Levine M (2004) Whole-genome analysis of Drosophila gastrulation. Curr Opin Genet Dev 14: 477-84 PubMed GONUTS page
  27. ↑ Anderson J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev Biol 297: 536-49 PubMed GONUTS page
  28. ↑ Bolatto C et al. (2003) Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila. J Neurobiol 54: 525-36 PubMed GONUTS page
  29. ↑ Bettencourt R et al. (2004) Hemolymph-dependent and -independent responses in Drosophila immune tissue. J Cell Biochem 92: 849-63 PubMed GONUTS page
  30. ↑ Matova N & Anderson KV (2006) Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense. Proc Natl Acad Sci U S A 103: 16424-9 PubMed GONUTS page
  31. ↑ Huang L et al. (2005) The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Dev Biol 280: 407-20 PubMed GONUTS page
  32. ↑ Copley RR et al. (2007) Functional conservation of Rel binding sites in drosophilid genomes. Genome Res 17: 1327-35 PubMed GONUTS page
  33. ↑ 33.0 33.1 Courey AJ & Jia S (2001) Transcriptional repression: the long and the short of it. Genes Dev 15: 2786-96 PubMed GONUTS page
  34. ↑ Ayyar S et al. (2007) NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS One 2: e1178 PubMed GONUTS page
  35. ↑ 35.0 35.1 Decoville M et al. (2000) HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors. Nucleic Acids Res 28: 454-62 PubMed GONUTS page
  36. ↑ Bhaskar V & Courey AJ (2002) The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Gene 299: 173-84 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/FB:dl"
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