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FB:dco
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | dco ( synonyms: 0538/13, 0915/10, 1396/02, 1447/01, 1460/09, CG2048, CK1delta/epsilon, CK1epsilon, CKIepsilon, Casein Kinase I epsilon, Casein Kinase Iepsilon, Casein kinase I epsilon, DBT, DBT/CK1epsilon, DCO, DCO/CKIe, DOUBLE-TIME, DOUBLETIME, Dbt, Dco, Dco/CK1, Discs overgrown, Double time, Double-Time, Double-time, Doubletime, ck1epsilon, dCKIepsilon, dbt, dco-1, ddbt, disc overgrown, double time, double-time, doubletime, l(3)S053813, l(3)S144701, l(3)dco, l(3)dco-1, l(3)discs overgrown, l(3)discs overgrown-1, l(3)j3B9, l(3)rK215 ) | |
| Protein Name(s) | discs overgrown, | |
| External Links | ||
| FB | FBgn0002413 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001737 |
establishment of imaginal disc-derived wing hair orientation |
FB:FBrf0191849 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001737 |
establishment of imaginal disc-derived wing hair orientation |
FB:FBrf0191945 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0103298 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0116978 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0193614 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0208009 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0191945 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0193614 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0208009 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0191945 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0159070 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0182901 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0190207 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0208432 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007154 |
cell communication |
FB:FBrf0051517 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007446 |
imaginal disc growth |
FB:FBrf0051517 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007446 |
imaginal disc growth |
FB:FBrf0065565 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007555 |
regulation of ecdysteroid secretion |
FB:FBrf0065565 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007622 |
rhythmic behavior |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0103298 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0103298 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003068 |
P |
From FB |
||
| GO:0007623 |
circadian rhythm |
FB:FBrf0123310 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0138449 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0141665 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0149124 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0159070 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0182901 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0205742 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0008062 |
eclosion rhythm |
FB:FBrf0151232 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
FB:FBrf0191849 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016301 |
kinase activity |
FB:FBrf0191945 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0016310 |
phosphorylation |
FB:FBrf0205742 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0030307 |
positive regulation of cell growth |
FB:FBrf0192905 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030431 |
sleep |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0042067 |
establishment of ommatidial planar polarity |
FB:FBrf0191849 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042067 |
establishment of ommatidial planar polarity |
FB:FBrf0191945 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042306 |
regulation of protein import into nucleus |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0192905 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045475 |
locomotor rhythm |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0048148 |
behavioral response to cocaine |
FB:FBrf0109239 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048148 |
behavioral response to cocaine |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0051781 |
positive regulation of cell division |
FB:FBrf0192905 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Klein TJ et al. (2006) CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol 16: 1337-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Strutt H et al. (2006) Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr Biol 16: 1329-36 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kloss B et al. (1998) The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94: 97-107 PubMed GONUTS page
- ↑ 4.0 4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol 54: 111-47 PubMed GONUTS page
- ↑ 6.0 6.1 Zhang L et al. (2006) Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol 299: 221-37 PubMed GONUTS page
- ↑ 7.0 7.1 Kotwica J et al. (2009) Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary. J Insect Physiol 55: 419-25 PubMed GONUTS page
- ↑ 8.0 8.1 Hendricks JC (2003) Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J Appl Physiol 94: 1660-72; discussion 1673 PubMed GONUTS page
- ↑ 9.0 9.1 Hardin PE (2000) From biological clock to biological rhythms. Genome Biol 1: REVIEWS1023 PubMed GONUTS page
- ↑ Jia J et al. (2005) Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell 9: 819-30 PubMed GONUTS page
- ↑ Feng Y & Irvine KD (2009) Processing and phosphorylation of the Fat receptor. Proc Natl Acad Sci U S A 106: 11989-94 PubMed GONUTS page
- ↑ 12.0 12.1 Jursnich VA et al. (1990) Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila. Dev Biol 140: 413-29 PubMed GONUTS page
- ↑ Bao S et al. (2001) The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. J Neurosci 21: 7117-26 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
- ↑ Panda S et al. (2002) Circadian rhythms from flies to human. Nature 417: 329-35 PubMed GONUTS page
- ↑ 16.0 16.1 Kivimäe S et al. (2008) Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol 6: e183 PubMed GONUTS page
- ↑ Stanewsky R (2002) Clock mechanisms in Drosophila. Cell Tissue Res 309: 11-26 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Guan J et al. (2007) The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol 303: 16-28 PubMed GONUTS page
- ↑ Andretic R et al. (1999) Requirement of circadian genes for cocaine sensitization in Drosophila. Science 285: 1066-8 PubMed GONUTS page
