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FB:da

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) da ( synonyms: 5102, CG5102, DA, Da, Daughterless, bHLHb22, daughter-less, l(2)31Ea )
Protein Name(s) daughterless,
External Links
FB FBgn0000413

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

FB:FBrf0076959
PMID:8078474[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003677

DNA binding

FB:FBrf0055582
PMID:1525829[2]

TAS: Traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0053886
PMID:1915272[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15923

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0123531

NAS: Non-traceable Author Statement

F

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15923

C

From FB

GO:0005634

nucleus

FB:FBrf0110073
PMID:10438607[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0123531

NAS: Non-traceable Author Statement

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0053886
PMID:1915272[3]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15923

P

From FB

GO:0006974

response to DNA damage stimulus

FB:FBrf0208272
PMID:19543366[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007399

nervous system development

FB:FBrf0055582
PMID:1525829[2]

TAS: Traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0123531

NAS: Non-traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0161619

TAS: Traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0083410
PMID:8060613[6]

TAS: Traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0131381
PMID:11102367[7]

TAS: Traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0144824
PMID:11880339[8]

NAS: Non-traceable Author Statement

P

From FB

GO:0007423

sensory organ development

FB:FBrf0190299
PMID:16554363[9]

IGI: Inferred from Genetic Interaction

FB:FBgn0002573

P

From FB

GO:0007423

sensory organ development

FB:FBrf0190299
PMID:16554363[9]

IGI: Inferred from Genetic Interaction

FB:FBgn0004170

P

From FB

GO:0007423

sensory organ development

FB:FBrf0190299
PMID:16554363[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007530

sex determination

FB:FBrf0055582
PMID:1525829[2]

TAS: Traceable Author Statement

P

From FB

GO:0007530

sex determination

FB:FBrf0123531

NAS: Non-traceable Author Statement

P

From FB

GO:0007530

sex determination

FB:FBrf0131266
PMID:11105896[10]

NAS: Non-traceable Author Statement

P

From FB

GO:0007530

sex determination

FB:FBrf0161619

TAS: Traceable Author Statement

P

From FB

GO:0007541

sex determination, primary response to X:A ratio

FB:FBrf0125416
PMID:10648226[11]

TAS: Traceable Author Statement

P

From FB

GO:0008134

transcription factor binding

FB:FBrf0155707
PMID:12466194[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0002633

F

From FB

GO:0008134

transcription factor binding

FB:FBrf0155707
PMID:12466194[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0002735

F

From FB

GO:0008407

chaeta morphogenesis

FB:FBrf0190182
PMID:16168983[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016330

second mitotic wave involved in compound eye morphogenesis

FB:FBrf0141762
PMID:11735386[14]

TAS: Traceable Author Statement

P

From FB

GO:0022008

neurogenesis

FB:FBrf0214431

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[15]

TAS: Traceable Author Statement

P

From FB

GO:0035019

somatic stem cell maintenance

FB:FBrf0209974
PMID:20147375[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0053776
PMID:1764999[17]

IPI: Inferred from Physical Interaction

FB:FBgn0000413

F

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0075104
PMID:7821225[18]

IPI: Inferred from Physical Interaction

FB:FBgn0000413

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0053776
PMID:1764999[17]

IDA: Inferred from Direct Assay

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0075104
PMID:7821225[18]

IDA: Inferred from Direct Assay

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0108816
PMID:10373509[19]

IDA: Inferred from Direct Assay

F

From FB

GO:0045464

R8 cell fate specification

FB:FBrf0144824
PMID:11880339[8]

NAS: Non-traceable Author Statement

P

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0053886
PMID:1915272[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0123097
PMID:10603347[20]

TAS: Traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0065441
PMID:8565819[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0053776
PMID:1764999[17]

IPI: Inferred from Physical Interaction

FB:FBgn0000022

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0053776
PMID:1764999[17]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0053776
PMID:1764999[17]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0053886
PMID:1915272[3]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0053886
PMID:1915272[3]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0000137

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0075104
PMID:7821225[18]

IPI: Inferred from Physical Interaction

FB:FBgn0000022

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0075104
PMID:7821225[18]

IPI: Inferred from Physical Interaction

FB:FBgn0000575

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0075104
PMID:7821225[18]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0075104
PMID:7821225[18]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0100349
PMID:9486535[22]

IPI: Inferred from Physical Interaction

FB:FBgn0022740

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0108816
PMID:10373509[19]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0126761
PMID:10707972[23]

IPI: Inferred from Physical Interaction

FB:FBgn0003270

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0138569
PMID:11688563[24]

IPI: Inferred from Physical Interaction

UniProtKB:P10627

F

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0180539
PMID:15485919[25]

IPI: Inferred from Physical Interaction

FB:FBgn0010433

F

From FB

GO:0048477

oogenesis

FB:FBrf0148972
PMID:12070099[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0161619

TAS: Traceable Author Statement

P

From FB

GO:0061101

neuroendocrine cell differentiation

FB:FBrf0215231
PMID:21901108[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061382

Malpighian tubule tip cell differentiation

FB:FBrf0075100
PMID:7821213[28]

IMP: Inferred from Mutant Phenotype

P

From FB

contributes_to

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0000137

F

From FB

contributes_to

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0002561

F

From FB

contributes_to

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0065441
PMID:8565819[21]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB

contributes_to

GO:0000981

sequence-specific DNA binding RNA polymerase II transcription factor activity

FB:FBrf0180539
PMID:15485919[25]

IPI: Inferred from Physical Interaction

FB:FBgn0010433

F

From FB

contributes_to

GO:0001012

RNA polymerase II regulatory region DNA binding

FB:FBrf0126761
PMID:10707972[23]

IPI: Inferred from Physical Interaction

FB:FBgn0003270

F

From FB

contributes_to

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

FB:FBrf0084040
PMID:7567454[29]

IPI: Inferred from Physical Interaction

FB:FBgn0004170

F

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Oellers N et al. (1994) bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet 244: 465-73 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Younger-Shepherd S et al. (1992) deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell 70: 911-22 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Cabrera CV & Alonso MC (1991) Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J 10: 2965-73 PubMed GONUTS page
  4. ↑ King-Jones K et al. (1999) The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. J Mol Biol 291: 71-82 PubMed GONUTS page
  5. ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
  6. ↑ Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
  7. ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
  8. ↑ 8.0 8.1 Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Jafar-Nejad H et al. (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133: 1683-92 PubMed GONUTS page
  10. ↑ Canon J & Banerjee U (2000) Runt and Lozenge function in Drosophila development. Semin Cell Dev Biol 11: 327-36 PubMed GONUTS page
  11. ↑ Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page
  12. ↑ 12.0 12.1 Giagtzoglou N et al. (2003) Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-70 PubMed GONUTS page
  13. ↑ Wildonger J & Mann RS (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286: 507-20 PubMed GONUTS page
  14. ↑ Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page
  15. ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  16. ↑ Bardin AJ et al. (2010) Transcriptional control of stem cell maintenance in the Drosophila intestine. Development 137: 705-14 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 17.4 Van Doren M et al. (1991) The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113: 245-55 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 18.3 18.4 18.5 Cabrera CV et al. (1994) Regulation of scute function by extramacrochaete in vitro and in vivo. Development 120: 3595-603 PubMed GONUTS page
  19. ↑ 19.0 19.1 Jennings BH et al. (1999) Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins. Mol Cell Biol 19: 4600-10 PubMed GONUTS page
  20. ↑ Lai EC et al. (2000) Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Development 127: 291-306 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 21.3 21.4 21.5 21.6 Jarman AP et al. (1993) The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Development 119: 19-29 PubMed GONUTS page
  22. ↑ Georgias C et al. (1997) A basic-helix-loop-helix protein expressed in precursors of Drosophila longitudinal visceral muscles. Mech Dev 69: 115-24 PubMed GONUTS page
  23. ↑ 23.0 23.1 Huang ML et al. (2000) The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 25: 57-67 PubMed GONUTS page
  24. ↑ Castanon I et al. (2001) Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development 128: 3145-59 PubMed GONUTS page
  25. ↑ 25.0 25.1 Powell LM et al. (2004) The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol Cell Biol 24: 9517-26 PubMed GONUTS page
  26. ↑ Smith JE 3rd et al. (2002) Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila. Development 129: 3255-67 PubMed GONUTS page
  27. ↑ Park S et al. (2011) Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. PLoS Genet 7: e1002241 PubMed GONUTS page
  28. ↑ Hoch M et al. (1994) Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila. Development 120: 3439-50 PubMed GONUTS page
  29. ↑ Hoshijima K et al. (1995) Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins. Nucleic Acids Res 23: 3441-8 PubMed GONUTS page
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