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FB:cry
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | cry ( synonyms: Blue-light receptor, CG3772, CRY, CRYPTOCHROME, Cry, Cryptochrome, DCry, Dm-CRY1, DmCRY, DmCRY1, Dmcry, anon-WO0140519.17, anon-WO0140519.19, anon-WO0140519.20, anon-WO0172774.15, cryb, crybaby, dCRY, dCry, dcry ) | |
| Protein Name(s) | cryptochrome, | |
| External Links | ||
| FB | FBgn0025680 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0030528 |
transcription regulator activity |
IMP: Inferred from Mutant Phenotype |
F |
Figure 3 |
complete | |||
| GO:0016564 |
transcription repressor activity |
IMP: Inferred from Mutant Phenotype |
F |
Figure 1 |
complete | |||
|
NOT |
GO:0016564 |
transcription repressor activity |
IMP: Inferred from Mutant Phenotype |
F |
Figure 5: Shows that CRY does not function as a repressor in pacemaker cells. |
complete | ||
| GO:0007623 |
circadian rhythm |
IMP: Inferred from Mutant Phenotype |
P |
Figure 4. cry^m^ flies were shown to have more variable ranges of PER |
complete | |||
| GO:0000060 |
protein import into nucleus, translocation |
FB:FBrf0137204 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003913 |
DNA photolyase activity |
FB:FBrf0141274 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0109474 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014396 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0137204 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0109474 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0205220 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005641 |
nuclear envelope lumen |
FB:FBrf0109474 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0109474 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0205220 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006281 |
DNA repair |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0007602 |
phototransduction |
FB:FBrf0204368 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0105814 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0105937 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003068 |
P |
From FB |
||
| GO:0007623 |
circadian rhythm |
FB:FBrf0105937 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0014396 |
P |
From FB |
||
| GO:0007623 |
circadian rhythm |
FB:FBrf0109474 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014396 |
P |
From FB |
||
| GO:0007623 |
circadian rhythm |
FB:FBrf0114858 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0135900 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0149124 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0151232 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0156173 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0159070 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008020 |
G-protein coupled photoreceptor activity |
FB:FBrf0108331 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:2384 |
F |
From FB |
||
| GO:0008020 |
G-protein coupled photoreceptor activity |
FB:FBrf0108331 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:2385 |
F |
From FB |
||
| GO:0009416 |
response to light stimulus |
FB:FBrf0151232 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009416 |
response to light stimulus |
FB:FBrf0155881 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009416 |
response to light stimulus |
FB:FBrf0179188 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009588 |
UV-A, blue light phototransduction |
FB:FBrf0108331 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:2384 |
P |
From FB |
||
| GO:0009588 |
UV-A, blue light phototransduction |
FB:FBrf0108331 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:2385 |
P |
From FB |
||
| GO:0009637 |
response to blue light |
FB:FBrf0156173 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0009637 |
response to blue light |
FB:FBrf0159070 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009649 |
entrainment of circadian clock |
FB:FBrf0152146 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009649 |
entrainment of circadian clock |
FB:FBrf0188183 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009649 |
entrainment of circadian clock |
FB:FBrf0202589 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009649 |
entrainment of circadian clock |
FB:FBrf0212447 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0009881 |
photoreceptor activity |
FB:FBrf0109474 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0009881 |
photoreceptor activity |
FB:FBrf0149124 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0009881 |
photoreceptor activity |
FB:FBrf0204368 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0009881 |
photoreceptor activity |
FB:FBrf0206285 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0009882 |
blue light photoreceptor activity |
FB:FBrf0107921 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0009882 |
blue light photoreceptor activity |
FB:FBrf0200368 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0042332 |
gravitaxis |
FB:FBrf0152255 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042752 |
regulation of circadian rhythm |
FB:FBrf0191052 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042752 |
regulation of circadian rhythm |
FB:FBrf0200368 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042752 |
regulation of circadian rhythm |
FB:FBrf0212447 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0043153 |
entrainment of circadian clock by photoperiod |
FB:FBrf0174852 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043153 |
entrainment of circadian clock by photoperiod |
FB:FBrf0179188 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043153 |
entrainment of circadian clock by photoperiod |
FB:FBrf0191431 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043234 |
protein complex |
FB:FBrf0109474 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014396 |
C |
From FB |
||
| GO:0045475 |
locomotor rhythm |
FB:FBrf0192726 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
FB:FBrf0190005 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
FB:FBrf0107921 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
FB:FBrf0200368 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
FB:FBrf0204368 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
FB:FBrf0206285 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0050958 |
magnetoreception |
FB:FBrf0207822 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050980 |
detection of light stimulus involved in magnetoreception |
FB:FBrf0205807 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071000 |
response to magnetism |
FB:FBrf0205807 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
NOT |
GO:0003913 |
DNA photolyase activity |
FB:FBrf0107921 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kume K et al. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98: 193-205 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Collins B et al. (2006) Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol 16: 441-9 PubMed GONUTS page
- ↑ Busza A et al. (2004) Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304: 1503-6 PubMed GONUTS page
- ↑ 4.0 4.1 Rosato E et al. (2001) Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Curr Biol 11: 909-17 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Ceriani MF et al. (1999) Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 285: 553-6 PubMed GONUTS page
- ↑ 6.0 6.1 Yoshii T et al. (2008) Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol 508: 952-66 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Oztürk N et al. (2008) Animal type 1 cryptochromes. Analysis of the redox state of the flavin cofactor by site-directed mutagenesis. J Biol Chem 283: 3256-63 PubMed GONUTS page
- ↑ Emery P et al. (1998) CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell 95: 669-79 PubMed GONUTS page
- ↑ 9.0 9.1 Stanewsky R et al. (1998) The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95: 681-92 PubMed GONUTS page
- ↑ Krishnan B et al. (2001) A new role for cryptochrome in a Drosophila circadian oscillator. Nature 411: 313-7 PubMed GONUTS page
- ↑ Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
- ↑ 12.0 12.1 Panda S et al. (2002) Circadian rhythms from flies to human. Nature 417: 329-35 PubMed GONUTS page
- ↑ 13.0 13.1 Stanewsky R (2002) Clock mechanisms in Drosophila. Cell Tissue Res 309: 11-26 PubMed GONUTS page
- ↑ 14.0 14.1 Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol 54: 111-47 PubMed GONUTS page
- ↑ 15.0 15.1 Glossop NR & Hardin PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J Cell Sci 115: 3369-77 PubMed GONUTS page
- ↑ 16.0 16.1 Hendricks JC (2003) Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J Appl Physiol 94: 1660-72; discussion 1673 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Egan ES et al. (1999) An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J Neurosci 19: 3665-73 PubMed GONUTS page
- ↑ 18.0 18.1 Dissel S et al. (2004) A constitutively active cryptochrome in Drosophila melanogaster. Nat Neurosci 7: 834-40 PubMed GONUTS page
- ↑ Helfrich-Förster C et al. (2002) The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function. J Neurosci 22: 9255-66 PubMed GONUTS page
- ↑ Yuan Q et al. (2005) Serotonin modulates circadian entrainment in Drosophila. Neuron 47: 115-27 PubMed GONUTS page
- ↑ Picot M et al. (2007) Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol 5: e315 PubMed GONUTS page
- ↑ 22.0 22.1 Yoshii T et al. (2010) Cryptochrome-positive and -negative clock neurons in Drosophila entrain differentially to light and temperature. J Biol Rhythms 25: 387-98 PubMed GONUTS page
- ↑ 23.0 23.1 Hoang N et al. (2008) Human and Drosophila cryptochromes are light activated by flavin photoreduction in living cells. PLoS Biol 6: e160 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 Okano S et al. (1999) A putative blue-light receptor from Drosophila melanogaster. Photochem Photobiol 69: 108-13 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Berndt A et al. (2007) A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome. J Biol Chem 282: 13011-21 PubMed GONUTS page
- ↑ Toma DP et al. (2002) Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat Genet 31: 349-53 PubMed GONUTS page
- ↑ Rieger D et al. (2006) Functional analysis of circadian pacemaker neurons in Drosophila melanogaster. J Neurosci 26: 2531-43 PubMed GONUTS page
- ↑ Klarsfeld A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci 24: 1468-77 PubMed GONUTS page
- ↑ Collins BH et al. (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc Natl Acad Sci U S A 102: 19021-6 PubMed GONUTS page
- ↑ Peschel N et al. (2006) Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc Natl Acad Sci U S A 103: 17313-8 PubMed GONUTS page
- ↑ Yoshii T et al. (2009) Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock. PLoS Biol 7: e1000086 PubMed GONUTS page
- ↑ 32.0 32.1 Gegear RJ et al. (2008) Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature 454: 1014-8 PubMed GONUTS page
