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FB:comm

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Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) comm ( synonyms: CG17943, Comm, Commissureless, Commisureless )
Protein Name(s) commissureless,
External Links
FB FBgn0010105

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002092

positive regulation of receptor internalization

FB:FBrf0151451
PMID:12165468[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005515

protein binding

FB:FBrf0151451
PMID:12165468[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VVI3

F

From FB

GO:0005515

protein binding

FB:FBrf0192388
PMID:17074801[2]

IPI: Inferred from Physical Interaction

FB:FBgn0259174

F

From FB

GO:0005794

Golgi apparatus

FB:FBrf0089842
PMID:8785048[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0089842
PMID:8785048[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0151451
PMID:12165468[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0192388
PMID:17074801[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0006897

endocytosis

FB:FBrf0141528
PMID:11697879[4]

TAS: Traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0149190
PMID:12079765[5]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0107807
PMID:10102267[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0124268

NAS: Non-traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0141528
PMID:11697879[4]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0151451
PMID:12165468[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0174512
PMID:15018941[7]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0207948
PMID:19325078[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0011592

P

From FB

GO:0007416

synapse assembly

FB:FBrf0141528
PMID:11697879[4]

TAS: Traceable Author Statement

P

From FB

GO:0007416

synapse assembly

FB:FBrf0192388
PMID:17074801[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008038

neuron recognition

FB:FBrf0156020
PMID:12526771[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0108154
PMID:10218152[10]

TAS: Traceable Author Statement

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0151451
PMID:12165468[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0193348
PMID:17049509[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030139

endocytic vesicle

FB:FBrf0192388
PMID:17074801[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0031623

receptor internalization

FB:FBrf0151451
PMID:12165468[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0031982

vesicle

FB:FBrf0151451
PMID:12165468[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0174512
PMID:15018941[7]

TAS: Traceable Author Statement

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0208790
PMID:19771146[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050699

WW domain binding

FB:FBrf0151451
PMID:12165468[1]

IPI: Inferred from Physical Interaction

FB:FBgn0259174

F

From FB

GO:0050699

WW domain binding

FB:FBrf0190636
PMID:16531238[13]

IDA: Inferred from Direct Assay

F

From FB

GO:0070983

dendrite guidance

FB:FBrf0159246
PMID:12592406[14]

IMP: Inferred from Mutant Phenotype

P

From FB

NOT

GO:0016199

axon midline choice point recognition

FB:FBrf0184197
PMID:15657595[15]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Myat, A et al. (2002) Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron 35 447-59 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Ing, B et al. (2007) Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol. Cell. Biol. 27 481-96 PubMed GONUTS page
  3. 3.0 3.1 Tear, G et al. (1996) commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein. Neuron 16 501-14 PubMed GONUTS page
  4. 4.0 4.1 4.2 Narayanan, R & Ramaswami, M (2001) Endocytosis in Drosophila: progress, possibilities, prognostications. Exp. Cell Res. 271 28-35 PubMed GONUTS page
  5. Hidalgo, A (2002) Interactive nervous system development: control of cell survival in Drosophila. Trends Neurosci. 25 365-70 PubMed GONUTS page
  6. Kidd, T et al. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96 785-94 PubMed GONUTS page
  7. 7.0 7.1 Grueber, WB & Jan, YN (2004) Dendritic development: lessons from Drosophila and related branches. Curr. Opin. Neurobiol. 14 74-82 PubMed GONUTS page
  8. Yang, L et al. (2009) A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance. Science 324 944-7 PubMed GONUTS page
  9. Zlatic, M et al. (2003) Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system. Neuron 37 41-51 PubMed GONUTS page
  10. Chiba, A (1999) Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development. Int. Rev. Neurobiol. 43 1-24 PubMed GONUTS page
  11. Simionato, E et al. (2007) The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. Dev. Biol. 301 166-77 PubMed GONUTS page
  12. Mauss, A et al. (2009) Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system. PLoS Biol. 7 e1000200 PubMed GONUTS page
  13. Kanelis, V et al. (2006) Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. Structure 14 543-53 PubMed GONUTS page
  14. Furrer, MP et al. (2003) Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline. Nat. Neurosci. 6 223-30 PubMed GONUTS page
  15. Keleman, K et al. (2005) Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo. Nat. Neurosci. 8 156-63 PubMed GONUTS page
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