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FB:ci
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | ci ( synonyms: CG2125, CI, CID, Ce, Cell, Ci, Ci-155, Ci/GLI, Ci/Gli, Ci155, CiD, Ci(D), Cubitis Interruptus, Cubitus Interuptus, Cubitus interruptus, Cubitus interuptus, Cubitus-interruptus, Gli, Siah, ci-D, ci155, ciD, ci(D), cubitis interruptus, cubitus interuptus, cubitus-interruptus, cubitus-interruptus-Dominant, cubitus-interruptus-dominant, l(4)102ABc, l(4)13, l(4)17 ) | |
| Protein Name(s) | cubitus interruptus, | |
| External Links | ||
| FB | FBgn0004859 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
FB:FBrf0093240 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0123711 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0125204 |
IPI: Inferred from Physical Interaction |
FB:FBgn0261617 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0190207 |
IPI: Inferred from Physical Interaction |
FB:FBgn0023423 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0207957 |
IPI: Inferred from Physical Interaction |
FB:FBgn0037657 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0210647 |
IPI: Inferred from Physical Interaction |
FB:FBgn0052062 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0123711 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0128675 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0132069 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0190106 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0210647 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0090554 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0128675 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0132069 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0190106 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0090554 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0125204 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0134579 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0145168 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0174381 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0189929 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007346 |
regulation of mitotic cell cycle |
FB:FBrf0135358 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007350 |
blastoderm segmentation |
FB:FBrf0156092 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007367 |
segment polarity determination |
FB:FBrf0051821 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008544 |
epidermis development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0174792 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0128450 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030858 |
positive regulation of epithelial cell differentiation |
FB:FBrf0205829 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035017 |
cuticle pattern formation |
FB:FBrf0190106 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035217 |
labial disc development |
FB:FBrf0183854 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035224 |
genital disc anterior/posterior pattern formation |
FB:FBrf0088118 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0035277 |
spiracle morphogenesis, open tracheal system |
FB:FBrf0187474 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035301 |
Hedgehog signaling complex |
FB:FBrf0128807 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000352 |
C |
From FB |
||
| GO:0035301 |
Hedgehog signaling complex |
FB:FBrf0128807 |
IPI: Inferred from Physical Interaction |
FB:FBgn0001079 |
C |
From FB |
||
| GO:0043234 |
protein complex |
FB:FBrf0102486 |
IPI: Inferred from Physical Interaction |
FB:FBgn0005355 |
C |
From FB |
||
| GO:0044212 |
transcription regulatory region DNA binding |
FB:FBrf0210647 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045750 |
positive regulation of S phase of mitotic cell cycle |
FB:FBrf0187405 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0093240 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0102450 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0125204 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261617 |
P |
From FB |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0125204 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048100 |
wing disc anterior/posterior pattern formation |
FB:FBrf0183859 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0090554 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0048592 |
eye morphogenesis |
FB:FBrf0193969 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0060914 |
heart formation |
FB:FBrf0089772 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
contributes_to |
GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0125204 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261617 |
F |
From FB |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Marsh JL & Theisen H (1999) Regeneration in insects. Semin Cell Dev Biol 10: 365-75 PubMed GONUTS page
- ↑ 2.0 2.1 Von Ohlen T et al. (1997) Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci U S A 94: 2404-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Chen Y et al. (2000) Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo. Mol Cell Biol 20: 1616-25 PubMed GONUTS page
- ↑ Jia J et al. (2005) Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell 9: 819-30 PubMed GONUTS page
- ↑ Mosimann C et al. (2009) The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mech Dev 126: 394-405 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Usha N & Shashidhara LS (2010) Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. Dev Biol 341: 389-99 PubMed GONUTS page
- ↑ 8.0 8.1 Wang QT & Holmgren RA (2000) Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-9 PubMed GONUTS page
- ↑ 9.0 9.1 Wang G et al. (2000) Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev 14: 2893-905 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Croker JA et al. (2006) Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains. Dev Biol 291: 368-81 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Forbes AJ et al. (1996) The role of segment polarity genes during early oogenesis in Drosophila. Development 122: 3283-94 PubMed GONUTS page
- ↑ Méthot N & Basler K (2001) An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development 128: 733-42 PubMed GONUTS page
- ↑ Curtiss J et al. (2002) Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol 4: E48-51 PubMed GONUTS page
- ↑ Ogden SK et al. (2004) Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol 67: 805-14 PubMed GONUTS page
- ↑ Yao S et al. (2006) The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125: 343-57 PubMed GONUTS page
- ↑ Zhang Y & Kalderon D (2001) Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604 PubMed GONUTS page
- ↑ Galis F et al. (2002) Conservation of the segmented germband stage: robustness or pleiotropy? Trends Genet 18: 504-9 PubMed GONUTS page
- ↑ Orenic TV et al. (1990) Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev 4: 1053-67 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
- ↑ Stegman MA et al. (2004) The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. J Biol Chem 279: 7064-71 PubMed GONUTS page
- ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
- ↑ Takashima S et al. (2008) The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature 454: 651-5 PubMed GONUTS page
- ↑ Joulia L et al. (2005) Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts. Dev Biol 278: 496-510 PubMed GONUTS page
- ↑ Freeland DE & Kuhn DT (1996) Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs. Mech Dev 56: 61-72 PubMed GONUTS page
- ↑ Merabet S et al. (2005) Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132: 3093-102 PubMed GONUTS page
- ↑ 26.0 26.1 Stegman MA et al. (2000) Identification of a tetrameric hedgehog signaling complex. J Biol Chem 275: 21809-12 PubMed GONUTS page
- ↑ Monnier V et al. (1998) Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Curr Biol 8: 583-6 PubMed GONUTS page
- ↑ Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
- ↑ Farese RV Jr & Herz J (1998) Cholesterol metabolism and embryogenesis. Trends Genet 14: 115-20 PubMed GONUTS page
- ↑ Shen J & Dahmann C (2005) The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev Biol 279: 31-43 PubMed GONUTS page
- ↑ Kent D et al. (2006) Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133: 2001-10 PubMed GONUTS page
- ↑ Park M et al. (1996) The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177: 104-16 PubMed GONUTS page
