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FB:cac
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | cac ( synonyms: 13, CG1522, CG15928, CG43368, Ca-alpha1A, Ca((V))2.1, Cac, Cacaphony, Cacophony, Calcium channel alpha1 subunit, type A, Dmca1A, Dmcalpha1A, EE171, H18, H47, L13, P18, alpha1A, cac1, cacaphony, l(1)11Aa, l(1)13, l(1)L13, lamina-degeneration, ldg, lethal(1)11Aa, nbA, night blind A, nightblind, nightblind A, no-on-transient B, nonB, opm18, opm47 ) | |
| Protein Name(s) | cacophony, | |
| External Links | ||
| FB | FBgn0263111 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002027 |
regulation of heart rate |
FB:FBrf0187886 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0005245 |
voltage-gated calcium channel activity |
FB:FBrf0124152 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005245 |
voltage-gated calcium channel activity |
FB:FBrf0127201 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005245 |
voltage-gated calcium channel activity |
FB:FBrf0151379 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0005245 |
voltage-gated calcium channel activity |
FB:FBrf0191926 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0005245 |
voltage-gated calcium channel activity |
FB:FBrf0206947 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005509 |
calcium ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005891 |
voltage-gated calcium channel complex |
FB:FBrf0124152 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005891 |
voltage-gated calcium channel complex |
FB:FBrf0127201 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005891 |
voltage-gated calcium channel complex |
FB:FBrf0134446 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005891 |
voltage-gated calcium channel complex |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0006816 |
calcium ion transport |
FB:FBrf0124152 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006816 |
calcium ion transport |
FB:FBrf0127201 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006816 |
calcium ion transport |
FB:FBrf0191926 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006887 |
exocytosis |
FB:FBrf0167966 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007268 |
synaptic transmission |
FB:FBrf0167806 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007268 |
synaptic transmission |
FB:FBrf0191926 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007269 |
neurotransmitter secretion |
FB:FBrf0128520 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007602 |
phototransduction |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007619 |
courtship behavior |
FB:FBrf0056527 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007619 |
courtship behavior |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007632 |
visual behavior |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008344 |
adult locomotory behavior |
FB:FBrf0101981 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008344 |
adult locomotory behavior |
FB:FBrf0127054 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000346 |
P |
From FB |
||
| GO:0016323 |
basolateral plasma membrane |
FB:FBrf0134446 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0134446 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0042045 |
epithelial fluid transport |
FB:FBrf0134446 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042045 |
epithelial fluid transport |
FB:FBrf0134446 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0045433 |
male courtship behavior, veined wing generated song production |
FB:FBrf0101981 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045433 |
male courtship behavior, veined wing generated song production |
FB:FBrf0103042 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045433 |
male courtship behavior, veined wing generated song production |
FB:FBrf0131304 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045433 |
male courtship behavior, veined wing generated song production |
FB:FBrf0141665 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
FB:FBrf0174769 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046928 |
regulation of neurotransmitter secretion |
FB:FBrf0207531 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261547 |
P |
From FB |
||
| GO:0048786 |
presynaptic active zone |
FB:FBrf0167806 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0050908 |
detection of light stimulus involved in visual perception |
FB:FBrf0103042 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051925 |
regulation of calcium ion transport via voltage-gated calcium channel activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ray VM & Dowse HB (2005) Mutations in and deletions of the Ca2+ channel-encoding gene cacophony, which affect courtship song in Drosophila, have novel effects on heartbeating. J Neurogenet 19: 39-56 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Littleton JT & Ganetzky B (2000) Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26: 35-43 PubMed GONUTS page
- ↑ Kawasaki F et al. (2002) Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony. J Neurosci 22: 5856-64 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Macleod GT et al. (2006) The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation. Eur J Neurosci 23: 3230-44 PubMed GONUTS page
- ↑ Gu H et al. (2009) Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol 101: 42-53 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 MacPherson MR et al. (2001) Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. Am J Physiol Cell Physiol 280: C394-407 PubMed GONUTS page
- ↑ Kuromi H et al. (2004) Ca2+ influx through distinct routes controls exocytosis and endocytosis at drosophila presynaptic terminals. Neuron 41: 101-11 PubMed GONUTS page
- ↑ 8.0 8.1 Kawasaki F et al. (2004) Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila. J Neurosci 24: 282-5 PubMed GONUTS page
- ↑ Kawasaki F et al. (2000) A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila. J Neurosci 20: 4885-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
- ↑ 11.0 11.1 Peixoto AA & Hall JC (1998) Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics 148: 827-38 PubMed GONUTS page
- ↑ Dellinger B et al. (2000) Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony. Genetics 155: 203-11 PubMed GONUTS page
- ↑ 13.0 13.1 Smith LA et al. (1998) Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila. Genetics 149: 1407-26 PubMed GONUTS page
- ↑ Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page
- ↑ Rieckhof GE et al. (2003) Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem 278: 41099-108 PubMed GONUTS page
- ↑ Frank CA et al. (2009) A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Neuron 61: 556-69 PubMed GONUTS page
