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FB:btl

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) btl ( synonyms: 0844/01, BTL/FGFR2, Breathless, Btl, CG32134, CG6714, CT20816, D-FGFR, DFGF-R1, DFR2, Dfr-2, DmHD-311, Dtk2, FGF receptor, FGFR, FGFR1, Fgf-r, Fibroblast growth factor receptor 1, Fibroblast-growth-factor-receptor, HD-311, Tk2, dFGFR, dev, devenir, dtk2, fgf-r, l(3)00208, lambdatop )
Protein Name(s) breathless,
External Links
FB FBgn0005592

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000187

activation of MAPK activity

FB:FBrf0147141
PMID:12175485[1]

IEP: Inferred from Expression Pattern

P

From FB

GO:0001763

morphogenesis of a branching structure

FB:FBrf0131240
PMID:11063940[2]

TAS: Traceable Author Statement

P

From FB

GO:0004713

protein tyrosine kinase activity

FB:FBrf0118625

NAS: Non-traceable Author Statement

F

From FB

GO:0004713

protein tyrosine kinase activity

FB:FBrf0124248

NAS: Non-traceable Author Statement

F

From FB

GO:0004713

protein tyrosine kinase activity

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0053997
PMID:1915852[4]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0054065
PMID:1849109[5]

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:95522

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0102528
PMID:9631645[6]

TAS: Traceable Author Statement

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0129696
PMID:10943305[7]

TAS: Traceable Author Statement

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0130167
PMID:11128983[8]

TAS: Traceable Author Statement

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0167264
PMID:14570584[9]

TAS: Traceable Author Statement

F

From FB

GO:0005007

fibroblast growth factor-activated receptor activity

FB:FBrf0179928
PMID:15475116[10]

TAS: Traceable Author Statement

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

From FB

GO:0005886

plasma membrane

FB:FBrf0053997
PMID:1915852[4]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005886

plasma membrane

FB:FBrf0054065
PMID:1849109[5]

IC: Inferred by Curator

GO:0005007

C

From FB

GO:0005886

plasma membrane

FB:FBrf0058097
PMID:8330538[11]

ISS: Inferred from Sequence or Structural Similarity

HGNC:3688

C

From FB

GO:0005886

plasma membrane

FB:FBrf0124248

NAS: Non-traceable Author Statement

C

From FB

GO:0006468

protein phosphorylation

FB:FBrf0124248

NAS: Non-traceable Author Statement

P

From FB

GO:0006468

protein phosphorylation

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0083323
PMID:7671793[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007417

central nervous system development

FB:FBrf0124248

NAS: Non-traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0054065
PMID:1849109[5]

IEP: Inferred from Expression Pattern

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0102528
PMID:9631645[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0130167
PMID:11128983[8]

TAS: Traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0131240
PMID:11063940[2]

NAS: Non-traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0139594
PMID:11598957[13]

TAS: Traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0160886
PMID:12885551[14]

TAS: Traceable Author Statement

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0148947
PMID:12015974[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0190195
PMID:16326394[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0054065
PMID:1849109[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0056113
PMID:1325393[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0084301
PMID:8541215[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0090661
PMID:8918892[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0125237
PMID:10684581[20]

TAS: Traceable Author Statement

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0129696
PMID:10943305[7]

TAS: Traceable Author Statement

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0144739
PMID:11835274[21]

TAS: Traceable Author Statement

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0168046
PMID:14624839[22]

TAS: Traceable Author Statement

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0211250
PMID:20516215[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0087684
PMID:8625828[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0090661
PMID:8918892[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0161023
PMID:12791296[25]

TAS: Traceable Author Statement

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0167264
PMID:14570584[9]

TAS: Traceable Author Statement

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0187390
PMID:15848387[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0192922
PMID:16831830[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007429

secondary branching, open tracheal system

FB:FBrf0087684
PMID:8625828[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007429

secondary branching, open tracheal system

FB:FBrf0090661
PMID:8918892[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007429

secondary branching, open tracheal system

FB:FBrf0167264
PMID:14570584[9]

TAS: Traceable Author Statement

P

From FB

GO:0007430

terminal branching, open tracheal system

FB:FBrf0084301
PMID:8541215[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007430

terminal branching, open tracheal system

FB:FBrf0090661
PMID:8918892[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007430

terminal branching, open tracheal system

FB:FBrf0125237
PMID:10684581[20]

TAS: Traceable Author Statement

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0139594
PMID:11598957[13]

NAS: Non-traceable Author Statement

P

From FB

GO:0007492

endoderm development

FB:FBrf0124248

NAS: Non-traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0124248

NAS: Non-traceable Author Statement

P

From FB

GO:0007517

muscle organ development

FB:FBrf0124248

NAS: Non-traceable Author Statement

P

From FB

GO:0008347

glial cell migration

FB:FBrf0056113
PMID:1325393[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008543

fibroblast growth factor receptor signaling pathway

FB:FBrf0102528
PMID:9631645[6]

TAS: Traceable Author Statement

P

From FB

GO:0008543

fibroblast growth factor receptor signaling pathway

FB:FBrf0129696
PMID:10943305[7]

TAS: Traceable Author Statement

P

From FB

GO:0008543

fibroblast growth factor receptor signaling pathway

FB:FBrf0144739
PMID:11835274[21]

NAS: Non-traceable Author Statement

P

From FB

GO:0008543

fibroblast growth factor receptor signaling pathway

FB:FBrf0167264
PMID:14570584[9]

TAS: Traceable Author Statement

P

From FB

GO:0030517

negative regulation of axon extension

FB:FBrf0192599
PMID:17032066[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035153

epithelial cell type specification, open tracheal system

FB:FBrf0192962
PMID:16760977[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035215

genital disc development

FB:FBrf0148926
PMID:12062107[30]

IEP: Inferred from Expression Pattern

P

From FB

GO:0046847

filopodium assembly

FB:FBrf0148947
PMID:12015974[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060446

branching involved in open tracheal system development

FB:FBrf0215238
PMID:21750259[31]

IMP: Inferred from Mutant Phenotype

P

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Ohshiro T et al. (2002) Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Mech Dev 114: 3-11 PubMed GONUTS page
  2. ↑ 2.0 2.1 Affolter M & Shilo BZ (2000) Genetic control of branching morphogenesis during Drosophila tracheal development. Curr Opin Cell Biol 12: 731-5 PubMed GONUTS page
  3. ↑ 3.0 3.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Shishido E et al. (1991) Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction. FEBS Lett 289: 235-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Glazer L & Shilo BZ (1991) The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension. Genes Dev 5: 697-705 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Bier E (1998) Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays 20: 189-94 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Affolter M (2000) Cell-cell interaction during Drosophila embryogenesis: novel mechanisms and molecules. Ernst Schering Res Found Workshop 65-79 PubMed GONUTS page
  8. ↑ 8.0 8.1 Wilson R & Leptin M (2000) Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm. Philos Trans R Soc Lond B Biol Sci 355: 891-5 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
  10. ↑ Itoh N & Ornitz DM (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet 20: 563-9 PubMed GONUTS page
  11. ↑ Shishido E et al. (1993) Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Development 117: 751-61 PubMed GONUTS page
  12. ↑ Murphy AM et al. (1995) The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration. Development 121: 2255-63 PubMed GONUTS page
  13. ↑ 13.0 13.1 Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
  14. ↑ Ribeiro C et al. (2003) Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila. Dev Biol 260: 1-8 PubMed GONUTS page
  15. ↑ 15.0 15.1 Ribeiro C et al. (2002) In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev Cell 2: 677-83 PubMed GONUTS page
  16. ↑ Cabernard C & Affolter M (2005) Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell 9: 831-42 PubMed GONUTS page
  17. ↑ 17.0 17.1 Klämbt C et al. (1992) breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells. Genes Dev 6: 1668-78 PubMed GONUTS page
  18. ↑ 18.0 18.1 Reichman-Fried M & Shilo BZ (1995) Breathless, a Drosophila FGF receptor homolog, is required for the onset of tracheal cell migration and tracheole formation. Mech Dev 52: 265-73 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 19.3 Lee T et al. (1996) Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes Dev 10: 2912-21 PubMed GONUTS page
  20. ↑ 20.0 20.1 Zelzer E & Shilo BZ (2000) Cell fate choices in Drosophila tracheal morphogenesis. Bioessays 22: 219-26 PubMed GONUTS page
  21. ↑ 21.0 21.1 Rosin D & Shilo BZ (2002) Branch-specific migration cues in the Drosophila tracheal system. Bioessays 24: 110-3 PubMed GONUTS page
  22. ↑ Nelson WJ (2003) Tube morphogenesis: closure, but many openings remain. Trends Cell Biol 13: 615-21 PubMed GONUTS page
  23. ↑ Hsouna A et al. (2010) Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis. Mol Cell Biol 30: 3779-94 PubMed GONUTS page
  24. ↑ 24.0 24.1 Samakovlis C et al. (1996) Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122: 1395-407 PubMed GONUTS page
  25. ↑ Uv A et al. (2003) Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems. Trends Cell Biol 13: 301-9 PubMed GONUTS page
  26. ↑ Myat MM et al. (2005) A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea. Dev Biol 281: 38-52 PubMed GONUTS page
  27. ↑ Cela C & Llimargas M (2006) Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development 133: 3115-25 PubMed GONUTS page
  28. ↑ Srahna M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol 4: e348 PubMed GONUTS page
  29. ↑ Ghabrial AS & Krasnow MA (2006) Social interactions among epithelial cells during tracheal branching morphogenesis. Nature 441: 746-9 PubMed GONUTS page
  30. ↑ Ahmad SM & Baker BS (2002) Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc. Cell 109: 651-61 PubMed GONUTS page
  31. ↑ Jones TA & Metzstein MM (2011) A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster. Genetics 189: 153-64 PubMed GONUTS page
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