GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:brat
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | brat ( synonyms: BRAT, Brain Tumor, Brain tumor, Brat, CG10719, Cf, E60, anon-37CDa, brain tumour, fs(2)ltoPM43, l(2)37Cf, l(2)E60, l(2)brat ) | |
| Protein Name(s) | brain tumor, | |
| External Links | ||
| FB | FBgn0010300 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002355 |
detection of tumor cell |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0005515 |
protein binding |
FB:FBrf0135777 |
IPI: Inferred from Physical Interaction |
FB:FBgn0002962 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0193740 |
IPI: Inferred from Physical Interaction |
FB:FBgn0053100 |
F |
From FB |
||
| GO:0005737 |
cytoplasm |
FB:FBrf0135777 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0189901 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006417 |
regulation of translation |
FB:FBrf0135777 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006417 |
regulation of translation |
FB:FBrf0152348 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007402 |
ganglion mother cell fate determination |
FB:FBrf0189901 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007405 |
neuroblast proliferation |
FB:FBrf0188152 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007406 |
negative regulation of neuroblast proliferation |
FB:FBrf0189901 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0210319 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007420 |
brain development |
FB:FBrf0194745 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0194745 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008356 |
asymmetric cell division |
FB:FBrf0189901 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009303 |
rRNA transcription |
FB:FBrf0144835 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016072 |
rRNA metabolic process |
FB:FBrf0144835 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0022008 |
neurogenesis |
FB:FBrf0214431 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030182 |
neuron differentiation |
FB:FBrf0190211 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030371 |
translation repressor activity |
FB:FBrf0135777 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0035282 |
segmentation |
FB:FBrf0193740 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045182 |
translation regulator activity |
FB:FBrf0152348 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0054123 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0161752 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0055060 |
asymmetric neuroblast division resulting in ganglion mother cell formation |
FB:FBrf0190211 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
colocalizes_with |
GO:0045179 |
apical cortex |
FB:FBrf0189901 |
IDA: Inferred from Direct Assay |
C |
From FB |
||
|
colocalizes_with |
GO:0045180 |
basal cortex |
FB:FBrf0189901 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Arama E et al. (2000) Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain. Oncogene 19: 3706-16 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Sonoda J & Wharton RP (2001) Drosophila Brain Tumor is a translational repressor. Genes Dev 15: 762-73 PubMed GONUTS page
- ↑ 3.0 3.1 Cho PF et al. (2006) Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr Biol 16: 2035-41 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Betschinger J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-53 PubMed GONUTS page
- ↑ 5.0 5.1 Dean KA et al. (2002) Translational repressors in Drosophila. Trends Genet 18: 572-7 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ Caussinus E & Gonzalez C (2005) Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37: 1125-9 PubMed GONUTS page
- ↑ Berger J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet 4: e1000085 PubMed GONUTS page
- ↑ 9.0 9.1 Bello B et al. (2006) The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development 133: 2639-48 PubMed GONUTS page
- ↑ 10.0 10.1 Frank DJ et al. (2002) The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. Development 129: 399-407 PubMed GONUTS page
- ↑ 11.0 11.1 Lee CY et al. (2006) Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev Cell 10: 441-9 PubMed GONUTS page
- ↑ Schüpbach T & Wieschaus E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129: 1119-36 PubMed GONUTS page
