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FB:baz

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) baz ( synonyms: Baz, Baz/Par-3, Baz/Par3, Bazooka, Bazooka-Par3, Bazooka/Par-3, CG5055, CG5505, D-Par3, D-par3, PAR-3, PAR3, Par-3, Par3, Usp36, dPar-3, l(1)G0484, par-3 )
Protein Name(s) bazooka,
External Links
FB FBgn0000163

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000910

cytokinesis

FB:FBrf0167741
PMID:14527345[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001738

morphogenesis of a polarized epithelium

FB:FBrf0167430
PMID:14644201[2]

TAS: Traceable Author Statement

P

From FB

GO:0002009

morphogenesis of an epithelium

FB:FBrf0141282
PMID:11700298[3]

TAS: Traceable Author Statement

P

From FB

GO:0005080

protein kinase C binding

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

protein_id:BAA34216

F

From FB

GO:0005515

protein binding

FB:FBrf0192517
PMID:17139248[4]

IPI: Inferred from Physical Interaction

FB:FBgn0026319

F

From FB

GO:0005912

adherens junction

FB:FBrf0187817
PMID:16129788[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0210663
PMID:20434988[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005913

cell-cell adherens junction

FB:FBrf0145778

NAS: Non-traceable Author Statement

C

From FB

GO:0005914

spot adherens junction

FB:FBrf0180376
PMID:15479740[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005915

zonula adherens

FB:FBrf0210551
PMID:20303268[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0005915

zonula adherens

FB:FBrf0211675
PMID:20819933[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0005938

cell cortex

FB:FBrf0174511
PMID:15018932[10]

TAS: Traceable Author Statement

C

From FB

GO:0007043

cell-cell junction assembly

FB:FBrf0145778

NAS: Non-traceable Author Statement

P

From FB

GO:0007043

cell-cell junction assembly

FB:FBrf0155643
PMID:12231350[11]

NAS: Non-traceable Author Statement

P

From FB

GO:0007163

establishment or maintenance of cell polarity

FB:FBrf0159915
PMID:12766944[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0007294

germarium-derived oocyte fate determination

FB:FBrf0141721
PMID:11734648[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0154638

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0180163
PMID:15456726[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007299

ovarian follicle cell-cell adhesion

FB:FBrf0158883
PMID:12642496[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007309

oocyte axis specification

FB:FBrf0158832
PMID:12517707[16]

TAS: Traceable Author Statement

P

From FB

GO:0007314

oocyte anterior/posterior axis specification

FB:FBrf0210668
PMID:20430751[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007377

germ-band extension

FB:FBrf0174540
PMID:15030758[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007377

germ-band extension

FB:FBrf0180080
PMID:15341764[19]

TAS: Traceable Author Statement

P

From FB

GO:0007416

synapse assembly

FB:FBrf0179422
PMID:15157419[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008105

asymmetric protein localization

FB:FBrf0128431
PMID:10887088[21]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0128431
PMID:10887088[21]

TAS: Traceable Author Statement

P

From FB

GO:0008594

photoreceptor cell morphogenesis

FB:FBrf0212822
PMID:21253601[22]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016324

apical plasma membrane

FB:FBrf0155643
PMID:12231350[11]

NAS: Non-traceable Author Statement

C

From FB

GO:0016324

apical plasma membrane

FB:FBrf0167430
PMID:14644201[2]

TAS: Traceable Author Statement

C

From FB

GO:0016325

oocyte microtubule cytoskeleton organization

FB:FBrf0210533
PMID:20152826[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016327

apicolateral plasma membrane

FB:FBrf0141282
PMID:11700298[3]

TAS: Traceable Author Statement

C

From FB

GO:0016332

establishment or maintenance of polarity of embryonic epithelium

FB:FBrf0141669
PMID:11740559[24]

NAS: Non-traceable Author Statement

P

From FB

GO:0030709

border follicle cell delamination

FB:FBrf0206227
PMID:18976916[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035003

subapical complex

FB:FBrf0155581
PMID:12500938[26]

TAS: Traceable Author Statement

C

From FB

GO:0035003

subapical complex

FB:FBrf0167430
PMID:14644201[2]

TAS: Traceable Author Statement

C

From FB

GO:0035089

establishment of apical/basal cell polarity

FB:FBrf0167999
PMID:14569003[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035089

establishment of apical/basal cell polarity

FB:FBrf0211675
PMID:20819933[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035091

phosphatidylinositol binding

FB:FBrf0210551
PMID:20303268[8]

IDA: Inferred from Direct Assay

F

From FB

GO:0040001

establishment of mitotic spindle localization

FB:FBrf0128431
PMID:10887088[21]

TAS: Traceable Author Statement

P

From FB

GO:0043296

apical junction complex

FB:FBrf0193051
PMID:16862128[28]

IDA: Inferred from Direct Assay

C

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0192517
PMID:17139248[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045175

basal protein localization

FB:FBrf0132418
PMID:11117748[29]

TAS: Traceable Author Statement

P

From FB

GO:0045176

apical protein localization

FB:FBrf0156163
PMID:11697883[30]

NAS: Non-traceable Author Statement

P

From FB

GO:0045177

apical part of cell

FB:FBrf0132418
PMID:11117748[29]

NAS: Non-traceable Author Statement

C

From FB

GO:0045179

apical cortex

FB:FBrf0132417
PMID:11117747[31]

TAS: Traceable Author Statement

C

From FB

GO:0045179

apical cortex

FB:FBrf0141669
PMID:11740559[24]

NAS: Non-traceable Author Statement

C

From FB

GO:0045186

zonula adherens assembly

FB:FBrf0141282
PMID:11700298[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0045186

zonula adherens assembly

FB:FBrf0155680
PMID:12530954[32]

TAS: Traceable Author Statement

P

From FB

GO:0045186

zonula adherens assembly

FB:FBrf0167430
PMID:14644201[2]

TAS: Traceable Author Statement

P

From FB

GO:0045186

zonula adherens assembly

FB:FBrf0180376
PMID:15479740[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045196

establishment or maintenance of neuroblast polarity

FB:FBrf0141670
PMID:11740560[33]

NAS: Non-traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0141282
PMID:11700298[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0141670
PMID:11740560[33]

NAS: Non-traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0155680
PMID:12530954[32]

TAS: Traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0158832
PMID:12517707[16]

TAS: Traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0187817
PMID:16129788[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0155600
PMID:12526793[34]

IGI: Inferred from Genetic Interaction

FB:FBgn0040080

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0174801
PMID:14981094[35]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060446

branching involved in open tracheal system development

FB:FBrf0215238
PMID:21750259[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0072002

Malpighian tubule development

FB:FBrf0208408
PMID:19567473[37]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0090250

cell-cell adhesion involved in establishment of planar polarity

FB:FBrf0211783
PMID:20833361[38]

IDA: Inferred from Direct Assay

P

From FB

GO:2000040

regulation of planar cell polarity pathway involved in axis elongation

FB:FBrf0211783
PMID:20833361[38]

IDA: Inferred from Direct Assay

P

From FB


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gibson MC & Perrimon N (2003) Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol 15: 747-52 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
  4. ↑ 4.0 4.1 Wang H et al. (2006) Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J 25: 5783-93 PubMed GONUTS page
  5. ↑ 5.0 5.1 Harris TJ & Peifer M (2005) The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. J Cell Biol 170: 813-23 PubMed GONUTS page
  6. ↑ Morais-de-Sá E et al. (2010) aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. Cell 141: 509-23 PubMed GONUTS page
  7. ↑ 7.0 7.1 Harris TJ & Peifer M (2004) Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. J Cell Biol 167: 135-47 PubMed GONUTS page
  8. ↑ 8.0 8.1 Krahn MP et al. (2010) Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. Curr Biol 20: 636-42 PubMed GONUTS page
  9. ↑ 9.0 9.1 Krahn MP et al. (2010) Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. J Cell Biol 190: 751-60 PubMed GONUTS page
  10. ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  11. ↑ 11.0 11.1 Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
  12. ↑ Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
  13. ↑ Cox DN et al. (2001) Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary. Proc Natl Acad Sci U S A 98: 14475-80 PubMed GONUTS page
  14. ↑ Pinheiro EM & Montell DJ (2004) Requirement for Par-6 and Bazooka in Drosophila border cell migration. Development 131: 5243-51 PubMed GONUTS page
  15. ↑ Abdelilah-Seyfried S et al. (2003) Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia. Development 130: 1927-35 PubMed GONUTS page
  16. ↑ 16.0 16.1 Ahringer J (2003) Control of cell polarity and mitotic spindle positioning in animal cells. Curr Opin Cell Biol 15: 73-81 PubMed GONUTS page
  17. ↑ Doerflinger H et al. (2010) Bazooka is required for polarisation of the Drosophila anterior-posterior axis. Development 137: 1765-73 PubMed GONUTS page
  18. ↑ Zallen JA & Wieschaus E (2004) Patterned gene expression directs bipolar planar polarity in Drosophila. Dev Cell 6: 343-55 PubMed GONUTS page
  19. ↑ Baum B (2004) Animal development: crowd control. Curr Biol 14: R716-8 PubMed GONUTS page
  20. ↑ Ruiz-Canada C et al. (2004) New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron 42: 567-80 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Cheah PY et al. (2000) Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates. Development 127: 3325-35 PubMed GONUTS page
  22. ↑ Chen G et al. (2011) Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. PLoS One 6: e16127 PubMed GONUTS page
  23. ↑ Becalska AN & Gavis ER (2010) Bazooka regulates microtubule organization and spatial restriction of germ plasm assembly in the Drosophila oocyte. Dev Biol 340: 528-38 PubMed GONUTS page
  24. ↑ 24.0 24.1 Hong Y et al. (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414: 634-8 PubMed GONUTS page
  25. ↑ McDonald JA et al. (2008) PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells. Curr Biol 18: 1659-67 PubMed GONUTS page
  26. ↑ Médina E et al. (2002) Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell 94: 305-13 PubMed GONUTS page
  27. ↑ Hong Y et al. (2003) Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture. Proc Natl Acad Sci U S A 100: 12712-7 PubMed GONUTS page
  28. ↑ Pilot F et al. (2006) Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature 442: 580-4 PubMed GONUTS page
  29. ↑ 29.0 29.1 Peng CY et al. (2000) The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600 PubMed GONUTS page
  30. ↑ Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
  31. ↑ Ohshiro T et al. (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-6 PubMed GONUTS page
  32. ↑ 32.0 32.1 Müller HA (2003) Epithelial polarity in flies: more than just crumbs. Dev Cell 4: 1-3 PubMed GONUTS page
  33. ↑ 33.0 33.1 Bachmann A et al. (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-43 PubMed GONUTS page
  34. ↑ Cai Y et al. (2003) Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112: 51-62 PubMed GONUTS page
  35. ↑ Izumi Y et al. (2004) Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. J Cell Biol 164: 729-38 PubMed GONUTS page
  36. ↑ Jones TA & Metzstein MM (2011) A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster. Genetics 189: 153-64 PubMed GONUTS page
  37. ↑ Campbell K et al. (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J Cell Sci 122: 2604-12 PubMed GONUTS page
  38. ↑ 38.0 38.1 Simões Sde M et al. (2010) Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell 19: 377-88 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/FB:baz"
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