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FB:arm

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) arm ( synonyms: ARM, Arm, Armadillo, Armadillo(Arm)/beta-catenin, Armadillo/beta-catenin, Armadillo/bgr;-catenin, Beta-catenin, Beta-catenin/Arm, CG11579, Dm Arm, EG:86E4.6, b-catenin, beta-Cat, beta-Catenin, beta-cat, beta-cat-arm, beta-catenin, beta-catenin/Arm, beta-catenin/Armadillo, betacat, betacatenin, catenin, l(1)2Bv, l(1)G0192, l(1)G0234, l(1)G0410, l(1)arm, t12687 ALR Dm )
Protein Name(s) armadillo,
External Links
FB FBgn0000117

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000902

cell morphogenesis

FB:FBrf0180376
PMID:15479740[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001709

cell fate determination

FB:FBrf0211056
PMID:20516152[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0167480
PMID:14602079[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003136

negative regulation of heart induction by canonical Wnt receptor signaling pathway

FB:FBrf0089772
PMID:8660881[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003713

transcription coactivator activity

FB:FBrf0174483
PMID:15043810[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0005515

protein binding

FB:FBrf0103449
PMID:9707400[6]

IPI: Inferred from Physical Interaction

UniProtKB:P22265

F

From FB

GO:0005515

protein binding

FB:FBrf0111426
PMID:10491393[7]

IPI: Inferred from Physical Interaction

FB:FBgn0026598

F

From FB

GO:0005515

protein binding

FB:FBrf0111426
PMID:10491393[7]

IPI: Inferred from Physical Interaction

FB:FBgn0086384

F

From FB

GO:0005515

protein binding

FB:FBrf0207596
PMID:19279137[8]

IPI: Inferred from Physical Interaction

FB:FBgn0026598

F

From FB

GO:0005515

protein binding

FB:FBrf0209417
PMID:19850033[9]

IPI: Inferred from Physical Interaction

FB:FBgn0026597

F

From FB

GO:0005515

protein binding

FB:FBrf0210642
PMID:20430750[10]

IPI: Inferred from Physical Interaction

FB:FBgn0036248

F

From FB

GO:0005634

nucleus

FB:FBrf0155963
PMID:12556495[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0174483
PMID:15043810[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0068630
PMID:8149915[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0123694

NAS: Non-traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0174483
PMID:15043810[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0068630
PMID:8149915[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0123694

NAS: Non-traceable Author Statement

C

From FB

GO:0005912

adherens junction

FB:FBrf0141596
PMID:11756472[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0141669
PMID:11740559[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0159915
PMID:12766944[15]

NAS: Non-traceable Author Statement

C

From FB

GO:0005914

spot adherens junction

FB:FBrf0155643
PMID:12231350[16]

NAS: Non-traceable Author Statement

C

From FB

GO:0005915

zonula adherens

FB:FBrf0058828
PMID:8227220[17]

IDA: Inferred from Direct Assay

C

From FB

GO:0007016

cytoskeletal anchoring at plasma membrane

FB:FBrf0129868
PMID:10908592[18]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0007155

cell adhesion

FB:FBrf0167741
PMID:14527345[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007155

cell adhesion

FB:FBrf0210158
PMID:20194639[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007163

establishment or maintenance of cell polarity

FB:FBrf0159915
PMID:12766944[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0007370

ventral furrow formation

FB:FBrf0180376
PMID:15479740[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007391

dorsal closure

FB:FBrf0141596
PMID:11756472[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0000578

P

From FB

GO:0007391

dorsal closure

FB:FBrf0155865
PMID:12551951[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007399

nervous system development

FB:FBrf0200690
PMID:17376868[22]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0123694

NAS: Non-traceable Author Statement

P

From FB

GO:0007472

wing disc morphogenesis

FB:FBrf0192456
PMID:16962574[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008092

cytoskeletal protein binding

FB:FBrf0132100
PMID:10908588[24]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0008360

regulation of cell shape

FB:FBrf0167741
PMID:14527345[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0014019

neuroblast development

FB:FBrf0180376
PMID:15479740[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016020

membrane

FB:FBrf0123694

NAS: Non-traceable Author Statement

C

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0068630
PMID:8149915[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:88276

P

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0123694

NAS: Non-traceable Author Statement

P

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0174483
PMID:15043810[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016324

apical plasma membrane

FB:FBrf0102882
PMID:9657150[25]

IDA: Inferred from Direct Assay

C

From FB

GO:0016327

apicolateral plasma membrane

FB:FBrf0141282
PMID:11700298[26]

TAS: Traceable Author Statement

C

From FB

GO:0016337

cell-cell adhesion

FB:FBrf0180376
PMID:15479740[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016337

cell-cell adhesion

FB:FBrf0205434
PMID:18460582[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016342

catenin complex

FB:FBrf0123694

NAS: Non-traceable Author Statement

C

From FB

GO:0016342

catenin complex

FB:FBrf0129868
PMID:10908592[18]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0019900

kinase binding

FB:FBrf0206511
PMID:19088090[28]

IPI: Inferred from Physical Interaction

FB:FBgn0035142

F

From FB

GO:0030424

axon

FB:FBrf0141596
PMID:11756472[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[29]

TAS: Traceable Author Statement

P

From FB

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

FB:FBrf0132360
PMID:11131529[30]

TAS: Traceable Author Statement

P

From FB

GO:0035017

cuticle pattern formation

FB:FBrf0187313
PMID:16005293[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035019

somatic stem cell maintenance

FB:FBrf0160968
PMID:12783796[32]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035147

branch fusion, open tracheal system

FB:FBrf0129763
PMID:11003842[33]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035147

branch fusion, open tracheal system

FB:FBrf0167508
PMID:14597571[34]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035153

epithelial cell type specification, open tracheal system

FB:FBrf0129763
PMID:11003842[33]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035293

chitin-based larval cuticle pattern formation

FB:FBrf0213500
PMID:19737741[35]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045186

zonula adherens assembly

FB:FBrf0180376
PMID:15479740[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045294

alpha-catenin binding

FB:FBrf0123694

NAS: Non-traceable Author Statement

F

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0206770
PMID:19176582[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0155963
PMID:12556495[11]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0174483
PMID:15043810[5]

IDA: Inferred from Direct Assay

P

From FB

GO:0046530

photoreceptor cell differentiation

FB:FBrf0187815
PMID:15897260[37]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046667

compound eye retinal cell programmed cell death

FB:FBrf0102882
PMID:9657150[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0160968
PMID:12783796[32]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048526

imaginal disc-derived wing expansion

FB:FBrf0192456
PMID:16962574[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048754

branching morphogenesis of a tube

FB:FBrf0129763
PMID:11003842[33]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060232

delamination

FB:FBrf0192456
PMID:16962574[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060914

heart formation

FB:FBrf0089772
PMID:8660881[4]

IMP: Inferred from Mutant Phenotype

P

From FB

contributes_to

GO:0001105

RNA polymerase II transcription coactivator activity

FB:FBrf0174483
PMID:15043810[5]

IPI: Inferred from Physical Interaction

FB:FBgn0039907

F

From FB

contributes_to

GO:0001105

RNA polymerase II transcription coactivator activity

FB:FBrf0174483
PMID:15043810[5]

IPI: Inferred from Physical Interaction

FB:FBgn0043900

F

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 Harris TJ & Peifer M (2004) Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. J Cell Biol 167: 135-47 PubMed GONUTS page
  2. ↑ Jones WM et al. (2010) Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. J Cell Sci 123: 2179-89 PubMed GONUTS page
  3. ↑ Tomlinson A (2003) Patterning the peripheral retina of the fly: decoding a gradient. Dev Cell 5: 799-809 PubMed GONUTS page
  4. ↑ 4.0 4.1 Park M et al. (1996) The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177: 104-16 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Thompson BJ (2004) A complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate wingless target genes. Curr Biol 14: 458-66 PubMed GONUTS page
  6. ↑ Gallet A et al. (1998) Trunk-specific modulation of wingless signalling in Drosophila by teashirt binding to armadillo. Curr Biol 8: 893-902 PubMed GONUTS page
  7. ↑ 7.0 7.1 McCartney BM et al. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol 146: 1303-18 PubMed GONUTS page
  8. ↑ Webb RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136: 1283-93 PubMed GONUTS page
  9. ↑ Kremer SA et al. (2010) In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin. Dev Biol 337: 110-23 PubMed GONUTS page
  10. ↑ Taniue K et al. (2010) Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development 137: 1755-64 PubMed GONUTS page
  11. ↑ 11.0 11.1 Park JM et al. (2003) Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 23: 1358-67 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Peifer M et al. (1994) wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120: 369-80 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Grevengoed EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol 155: 1185-98 PubMed GONUTS page
  14. ↑ Hong Y et al. (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414: 634-8 PubMed GONUTS page
  15. ↑ 15.0 15.1 Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
  16. ↑ Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
  17. ↑ Peifer M (1993) The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J Cell Sci 105 ( Pt 4): 993-1000 PubMed GONUTS page
  18. ↑ 18.0 18.1 Hynes RO & Zhao Q (2000) The evolution of cell adhesion. J Cell Biol 150: F89-96 PubMed GONUTS page
  19. ↑ 19.0 19.1 Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  20. ↑ Martin AC et al. (2010) Integration of contractile forces during tissue invagination. J Cell Biol 188: 735-49 PubMed GONUTS page
  21. ↑ Myster SH et al. (2003) Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J Cell Biol 160: 433-49 PubMed GONUTS page
  22. ↑ Koizumi K et al. (2007) RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci U S A 104: 5626-31 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 Kiger JA Jr et al. (2007) Tissue remodeling during maturation of the Drosophila wing. Dev Biol 301: 178-91 PubMed GONUTS page
  24. ↑ Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
  25. ↑ 25.0 25.1 Ahmed Y et al. (1998) Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93: 1171-82 PubMed GONUTS page
  26. ↑ Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
  27. ↑ Sokac AM & Wieschaus E (2008) Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization. J Cell Sci 121: 1815-24 PubMed GONUTS page
  28. ↑ Lee W et al. (2009) Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression. Development 136: 241-51 PubMed GONUTS page
  29. ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  30. ↑ Deng W & Lin H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int Rev Cytol 203: 93-138 PubMed GONUTS page
  31. ↑ Hoffmans R et al. (2005) Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Curr Biol 15: 1207-11 PubMed GONUTS page
  32. ↑ 32.0 32.1 Song X & Xie T (2003) Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development 130: 3259-68 PubMed GONUTS page
  33. ↑ 33.0 33.1 33.2 Chihara T & Hayashi S (2000) Control of tracheal tubulogenesis by Wingless signaling. Development 127: 4433-42 PubMed GONUTS page
  34. ↑ Lee M et al. (2003) Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusion. Development 130: 5989-99 PubMed GONUTS page
  35. ↑ Kaplan NA et al. (2009) Epithelial polarity: interactions between junctions and apical-basal machinery. Genetics 183: 897-904 PubMed GONUTS page
  36. ↑ Dichtel-Danjoy ML et al. (2009) SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc. Development 136: 761-9 PubMed GONUTS page
  37. ↑ Beronja S et al. (2005) Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. J Cell Biol 169: 635-46 PubMed GONUTS page
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