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FB:aret

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) aret ( synonyms: Aret, BcDNA:GM15173, Bru, Bruno, CG31762, CG6319, Dm Bru, NEST:bs01g04, NEST:bs34h11, aret/bruno1, arrest/Bruno, bru, bruno, ms(2)01284 )
Protein Name(s) arrest,
External Links
FB FBgn0000114

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR012677

F

From FB

GO:0000381

regulation of alternative nuclear mRNA splicing, via spliceosome

FB:FBrf0180650
PMID:15492211[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0002121

inter-male aggressive behavior

FB:FBrf0208496
PMID:19519879[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003723

RNA binding

FB:FBrf0189903
PMID:16469699[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0003729

mRNA binding

FB:FBrf0086125

NAS: Non-traceable Author Statement

F

From FB

GO:0003729

mRNA binding

FB:FBrf0110978
PMID:10449356[4]

TAS: Traceable Author Statement

F

From FB

GO:0003729

mRNA binding

FB:FBrf0129923
PMID:10908586[5]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0003729

mRNA binding

FB:FBrf0148886

ISS: Inferred from Sequence or Structural Similarity

HGNC:2550

F

From FB

GO:0003729

mRNA binding

FB:FBrf0152348
PMID:12414187[6]

NAS: Non-traceable Author Statement

F

From FB

GO:0003730

mRNA 3'-UTR binding

FB:FBrf0152348
PMID:12414187[6]

TAS: Traceable Author Statement

F

From FB

GO:0003730

mRNA 3'-UTR binding

FB:FBrf0157198
PMID:12591598[7]

IDA: Inferred from Direct Assay

F

From FB

GO:0005515

protein binding

FB:FBrf0107851
PMID:10021333[8]

IPI: Inferred from Physical Interaction

FB:FBgn0015903

F

From FB

GO:0005515

protein binding

FB:FBrf0155723
PMID:12538512[9]

IPI: Inferred from Physical Interaction

FB:FBgn0004882

F

From FB

GO:0005634

nucleus

FB:FBrf0180650
PMID:15492211[1]

IC: Inferred by Curator

GO:0000381

C

From FB

GO:0006378

mRNA polyadenylation

FB:FBrf0132360
PMID:11131529[10]

TAS: Traceable Author Statement

P

From FB

GO:0007281

germ cell development

FB:FBrf0190220
PMID:16399084[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007286

spermatid development

FB:FBrf0064394
PMID:8244010[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0086125

NAS: Non-traceable Author Statement

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0103246
PMID:9642168[13]

TAS: Traceable Author Statement

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0141280
PMID:11700288[14]

TAS: Traceable Author Statement

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0152348
PMID:12414187[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0157336
PMID:12655640[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0007319

negative regulation of oskar mRNA translation

FB:FBrf0189903
PMID:16469699[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0017148

negative regulation of translation

FB:FBrf0157198
PMID:12591598[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030727

germarium-derived female germ-line cyst formation

FB:FBrf0132360
PMID:11131529[10]

TAS: Traceable Author Statement

P

From FB

GO:0031536

positive regulation of exit from mitosis

FB:FBrf0190220
PMID:16399084[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042078

germ-line stem cell division

FB:FBrf0132360
PMID:11131529[10]

NAS: Non-traceable Author Statement

P

From FB

GO:0043186

P granule

FB:FBrf0174811
PMID:15090597[16]

IDA: Inferred from Direct Assay

C

From FB

GO:0046011

regulation of oskar mRNA translation

FB:FBrf0132360
PMID:11131529[10]

TAS: Traceable Author Statement

P

From FB

GO:0048477

oogenesis

FB:FBrf0054123
PMID:1783295[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0135959
PMID:11309853[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0157198
PMID:12591598[7]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Park JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A 101: 15974-9 PubMed GONUTS page
  2. Edwards AC et al. (2009) Mutations in many genes affect aggressive behavior in Drosophila melanogaster. BMC Biol 7: 29 PubMed GONUTS page
  3. 3.0 3.1 Chekulaeva M et al. (2006) Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell 124: 521-33 PubMed GONUTS page
  4. van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page
  5. Lasko P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J Cell Biol 150: F51-6 PubMed GONUTS page
  6. 6.0 6.1 6.2 Dean KA et al. (2002) Translational repressors in Drosophila. Trends Genet 18: 572-7 PubMed GONUTS page
  7. 7.0 7.1 7.2 Filardo P & Ephrussi A (2003) Bruno regulates gurken during Drosophila oogenesis. Mech Dev 120: 289-97 PubMed GONUTS page
  8. Lie YS & Macdonald PM (1999) Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation. Development 126: 1129-38 PubMed GONUTS page
  9. Castagnetti S & Ephrussi A (2003) Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte. Development 130: 835-43 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Deng W & Lin H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int Rev Cytol 203: 93-138 PubMed GONUTS page
  11. 11.0 11.1 Sugimura I & Lilly MA (2006) Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Dev Cell 10: 127-35 PubMed GONUTS page
  12. Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page
  13. Cooperstock RL & Lipshitz HD (1997) Control of mRNA stability and translation during Drosophila development. Semin Cell Dev Biol 8: 541-9 PubMed GONUTS page
  14. Johnstone O & Lasko P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu Rev Genet 35: 365-406 PubMed GONUTS page
  15. Leatherman JL & Jongens TA (2003) Transcriptional silencing and translational control: key features of early germline development. Bioessays 25: 326-35 PubMed GONUTS page
  16. Snee MJ & Macdonald PM (2004) Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components. J Cell Sci 117: 2109-20 PubMed GONUTS page
  17. Schüpbach T & Wieschaus E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129: 1119-36 PubMed GONUTS page
  18. Parisi MJ et al. (2001) The arrest gene is required for germline cyst formation during Drosophila oogenesis. Genesis 29: 196-209 PubMed GONUTS page
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