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FB:ap

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) ap ( synonyms: AP, APTEROUS, Ap, Apt, Apterous, CG8376, LIM, S-2a, Xa, Xasta, blt, no-wings, tornwing, trw )
Protein Name(s) apterous,
External Links
FB FBgn0000099

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0106026
PMID:9806924[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P36198

F

From FB

GO:0005634

nucleus

FB:FBrf0123927

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0127419
PMID:10751171[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0212480
PMID:8595880[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0006351

transcription, DNA-dependent

FB:FBrf0127419
PMID:10751171[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006351

transcription, DNA-dependent

FB:FBrf0127419
PMID:10751171[2]

TAS: Traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0127419
PMID:10751171[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007399

nervous system development

FB:FBrf0158840
PMID:12593977[4]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0127419
PMID:10751171[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007450

dorsal/ventral pattern formation, imaginal disc

FB:FBrf0151319
PMID:12119094[5]

TAS: Traceable Author Statement

P

From FB

GO:0007451

dorsal/ventral lineage restriction, imaginal disc

FB:FBrf0141064
PMID:11253649[6]

TAS: Traceable Author Statement

P

From FB

GO:0007472

wing disc morphogenesis

FB:FBrf0123927

NAS: Non-traceable Author Statement

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0151319
PMID:12119094[5]

TAS: Traceable Author Statement

P

From FB

GO:0007479

leg disc proximal/distal pattern formation

FB:FBrf0131382
PMID:11076760[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007481

haltere disc morphogenesis

FB:FBrf0123927

NAS: Non-traceable Author Statement

P

From FB

GO:0007517

muscle organ development

FB:FBrf0131298
PMID:11076753[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0151208
PMID:12111720[9]

TAS: Traceable Author Statement

P

From FB

GO:0007526

larval somatic muscle development

FB:FBrf0212632
PMID:21179520[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007559

histolysis

FB:FBrf0058455
PMID:8440351[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008270

zinc ion binding

FB:FBrf0123927

NAS: Non-traceable Author Statement

F

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001781

F

From FB

GO:0035218

leg disc development

FB:FBrf0179395
PMID:15175252[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0036011

imaginal disc-derived leg segmentation

FB:FBrf0179395
PMID:15175252[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045165

cell fate commitment

FB:FBrf0138533
PMID:11486054[13]

NAS: Non-traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0106026
PMID:9806924[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0141064
PMID:11253649[6]

TAS: Traceable Author Statement

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0190133
PMID:16307735[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0202749
PMID:18202376[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0000242
FB:FBgn0000099

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Benveniste RJ et al. (1998) Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125: 4757-65 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 van Meyel DJ et al. (2000) Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila. Development 127: 1823-31 PubMed GONUTS page
  3. Arber S & Caroni P (1996) Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Genes Dev 10: 289-300 PubMed GONUTS page
  4. Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
  5. 5.0 5.1 Calleja M et al. (2002) How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292: 1-12 PubMed GONUTS page
  6. 6.0 6.1 McNeill H (2000) Sticking together and sorting things out: adhesion as a force in development. Nat Rev Genet 1: 100-8 PubMed GONUTS page
  7. Pueyo JI et al. (2000) Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1. Development 127: 5391-402 PubMed GONUTS page
  8. Ghazi A et al. (2000) Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. Development 127: 5309-18 PubMed GONUTS page
  9. Dworak HA & Sink H (2002) Myoblast fusion in Drosophila. Bioessays 24: 591-601 PubMed GONUTS page
  10. Müller D et al. (2010) Regulation and functions of the lms homeobox gene during development of embryonic lateral transverse muscles and direct flight muscles in Drosophila. PLoS One 5: e14323 PubMed GONUTS page
  11. Richard DS et al. (1993) A reappraisal of the hormonal regulation of larval fat body histolysis in female Drosophila melanogaster. Experientia 49: 150-6 PubMed GONUTS page
  12. 12.0 12.1 Pueyo JI & Couso JP (2004) Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development. Development 131: 3107-20 PubMed GONUTS page
  13. Furlong EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293: 1629-33 PubMed GONUTS page
  14. Koelzer S & Klein T (2006) Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol 289: 77-90 PubMed GONUTS page
  15. Bejarano F et al. (2008) A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Genetics 178: 307-23 PubMed GONUTS page
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