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FB:alpha-Adaptin

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) alpha-Adaptin ( synonyms: AP-2, AP-2alpha, AP2, Alpha-Adaptin, Alpha-adaptin, CG31654, CG4260, D-Ada, D-alphaAda, MENE (2L)-A, MENE(2L)-A, ada, alpha, alpha adaptin, alpha-Ada, alpha-ada, alpha-adaptin, alphaAdaptin, cg4260, dAP-2a, l(2)06694 )
Protein Name(s) alpha-Adaptin,
External Links
FB FBgn0263350

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005488

binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR011989
InterPro:IPR016024

F

From FB

GO:0005886

plasma membrane

FB:FBrf0093110
PMID:9118220[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0210975

IDA: Inferred from Direct Assay

C

From FB

GO:0006886

intracellular protein transport

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR002553
InterPro:IPR003164
InterPro:IPR008152
InterPro:IPR009028
InterPro:IPR013038
InterPro:IPR015873

P

From FB

GO:0006897

endocytosis

FB:FBrf0210409
PMID:20226669[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006901

vesicle coating

FB:FBrf0108281
PMID:10218159[3]

TAS: Traceable Author Statement

P

From FB

GO:0007269

neurotransmitter secretion

FB:FBrf0108281
PMID:10218159[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0008021

synaptic vesicle

FB:FBrf0108281
PMID:10218159[3]

TAS: Traceable Author Statement

C

From FB

GO:0008104

protein localization

FB:FBrf0188062
PMID:15901829[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0174511
PMID:15018932[5]

TAS: Traceable Author Statement

P

From FB

GO:0008565

protein transporter activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR017104

F

From FB

GO:0016183

synaptic vesicle coating

FB:FBrf0108281
PMID:10218159[3]

TAS: Traceable Author Statement

P

From FB

GO:0016192

vesicle-mediated transport

FB:FBrf0124164

NAS: Non-traceable Author Statement

P

From FB

GO:0022008

neurogenesis

FB:FBrf0214431

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030100

regulation of endocytosis

FB:FBrf0191981
PMID:16835270[6]

IDA: Inferred from Direct Assay

P

From FB

GO:0030122

AP-2 adaptor complex

FB:FBrf0115359

NAS: Non-traceable Author Statement

C

From FB

GO:0030122

AP-2 adaptor complex

FB:FBrf0124164

NAS: Non-traceable Author Statement

C

From FB

GO:0030131

clathrin adaptor complex

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR003164
InterPro:IPR008152
InterPro:IPR013038

C

From FB

GO:0030135

coated vesicle

FB:FBrf0108281
PMID:10218159[3]

TAS: Traceable Author Statement

C

From FB

GO:0045807

positive regulation of endocytosis

FB:FBrf0187517
PMID:16113648[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048489

synaptic vesicle transport

FB:FBrf0141528
PMID:11697879[8]

TAS: Traceable Author Statement

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. González-Gaitán M & Jäckle H (1997) Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell 88: 767-76 PubMed GONUTS page
  2. Windler SL & Bilder D (2010) Endocytic internalization routes required for delta/notch signaling. Curr Biol 20: 538-43 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Stimson DT & Ramaswami M (1999) Vesicle recycling at the Drosophila neuromuscular junction. Int Rev Neurobiol 43: 163-89 PubMed GONUTS page
  4. Roegiers F et al. (2005) Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell 16: 3480-7 PubMed GONUTS page
  5. Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  6. Orem NR et al. (2006) An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor. J Cell Sci 119: 3141-8 PubMed GONUTS page
  7. Hutterer A & Knoblich JA (2005) Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep 6: 836-42 PubMed GONUTS page
  8. Narayanan R & Ramaswami M (2001) Endocytosis in Drosophila: progress, possibilities, prognostications. Exp Cell Res 271: 28-35 PubMed GONUTS page
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