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FB:abd-A

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) abd-A ( synonyms: Abd-A, AbdA, Abda, Abdominal-A, BX-C, CG10325, Cbxd, Contrabithoraxoid, DmabdA, Dmabda, Hab, Hyperabdominal, Ultraabdominal, abd A, abd-a, abdA, abd_a, abda, abdominal-A, abdominal-a, abdominalA, iab, iab-2, iab-3, iab-4, iab-5, iab2, iab3, iab4, infra-abdominal 2, infra-abdominal 3, infra-abdominal 4, infraabdominal, l(3)89Ec )
Protein Name(s) abdominal A,
External Links
FB FBgn0000014

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0051832
PMID:1979297[1]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

NAS: Non-traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0123921

NAS: Non-traceable Author Statement

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0205665
PMID:18694568[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0209175
PMID:14507783[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0105495

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0123921

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0205665
PMID:18694568[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0205665
PMID:18694568[2]

IPI: Inferred from Physical Interaction

FB:FBgn0000611

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0205665
PMID:18694568[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001235

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0051832
PMID:1979297[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006915

apoptotic process

FB:FBrf0156017
PMID:12546817[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006915

apoptotic process

FB:FBrf0187453
PMID:16049114[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007280

pole cell migration

FB:FBrf0102832
PMID:9637912[6]

TAS: Traceable Author Statement

P

From FB

GO:0007385

specification of segmental identity, abdomen

FB:FBrf0123921

NAS: Non-traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0156017
PMID:12546817[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007399

nervous system development

FB:FBrf0187453
PMID:16049114[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0184186
PMID:15580266[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0083410
PMID:8060613[8]

TAS: Traceable Author Statement

P

From FB

GO:0007438

oenocyte development

FB:FBrf0148967
PMID:12050142[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007494

midgut development

FB:FBrf0111439
PMID:10512197[10]

TAS: Traceable Author Statement

P

From FB

GO:0007501

mesodermal cell fate specification

FB:FBrf0151925
PMID:12223408[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007501

mesodermal cell fate specification

FB:FBrf0151932
PMID:12397110[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007506

gonadal mesoderm development

FB:FBrf0100771
PMID:9435287[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007507

heart development

FB:FBrf0151925
PMID:12223408[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008354

germ cell migration

FB:FBrf0100771
PMID:9435287[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008354

germ cell migration

FB:FBrf0107500
PMID:9988212[14]

TAS: Traceable Author Statement

P

From FB

GO:0008406

gonad development

FB:FBrf0078100

NAS: Non-traceable Author Statement

P

From FB

GO:0008406

gonad development

FB:FBrf0102832
PMID:9637912[6]

TAS: Traceable Author Statement

P

From FB

GO:0009952

anterior/posterior pattern specification

FB:FBrf0051832
PMID:1979297[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009987

cellular process

FB:FBrf0175143
PMID:14764878[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0010002

cardioblast differentiation

FB:FBrf0190311
PMID:16284119[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0014019

neuroblast development

FB:FBrf0206246
PMID:18948419[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035053

dorsal vessel heart proper cell fate commitment

FB:FBrf0151890
PMID:12435360[18]

IEP: Inferred from Expression Pattern

P

From FB

GO:0035053

dorsal vessel heart proper cell fate commitment

FB:FBrf0151890
PMID:12435360[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035053

dorsal vessel heart proper cell fate commitment

FB:FBrf0151932
PMID:12397110[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035053

dorsal vessel heart proper cell fate commitment

FB:FBrf0160748
PMID:12837580[19]

TAS: Traceable Author Statement

P

From FB

GO:0035053

dorsal vessel heart proper cell fate commitment

FB:FBrf0190311
PMID:16284119[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035224

genital disc anterior/posterior pattern formation

FB:FBrf0088118
PMID:8798147[20]

IEP: Inferred from Expression Pattern

P

From FB

GO:0035225

determination of genital disc primordium

FB:FBrf0187379
PMID:15893978[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0055563
PMID:1358457[22]

IDA: Inferred from Direct Assay

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0209175
PMID:14507783[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0209175
PMID:14507783[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048636

positive regulation of muscle organ development

FB:FBrf0208061
PMID:19272319[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048738

cardiac muscle tissue development

FB:FBrf0190311
PMID:16284119[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048806

genitalia development

FB:FBrf0190286
PMID:16319117[24]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Karch F et al. (1990) abdA expression in Drosophila embryos. Genes Dev 4: 1573-87 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Li-Kroeger D et al. (2008) Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev Cell 15: 298-308 PubMed GONUTS page
  3. 3.0 3.1 3.2 Grienenberger A et al. (2003) Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130: 5445-55 PubMed GONUTS page
  4. 4.0 4.1 Bello BC et al. (2003) A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. Neuron 37: 209-19 PubMed GONUTS page
  5. 5.0 5.1 Cenci C & Gould AP (2005) Drosophila Grainyhead specifies late programmes of neural proliferation by regulating the mitotic activity and Hox-dependent apoptosis of neuroblasts. Development 132: 3835-45 PubMed GONUTS page
  6. 6.0 6.1 Howard K (1998) Organogenesis: Drosophila goes gonadal. Curr Biol 8: R415-7 PubMed GONUTS page
  7. Berger C et al. (2005) A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat Cell Biol 7: 56-62 PubMed GONUTS page
  8. Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
  9. Brodu V et al. (2002) abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129: 2957-63 PubMed GONUTS page
  10. Murakami R et al. (1999) Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation. Cell Mol Biol (Noisy-le-grand) 45: 661-76 PubMed GONUTS page
  11. 11.0 11.1 Ponzielli R et al. (2002) Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling. Development 129: 4509-21 PubMed GONUTS page
  12. 12.0 12.1 Lovato TL et al. (2002) The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Development 129: 5019-27 PubMed GONUTS page
  13. 13.0 13.1 Moore LA et al. (1998) Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila. Development 125: 667-78 PubMed GONUTS page
  14. Wylie C (1999) Germ cells. Cell 96: 165-74 PubMed GONUTS page
  15. Boutros M et al. (2004) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303: 832-5 PubMed GONUTS page
  16. 16.0 16.1 16.2 Monier B et al. (2005) Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart. Development 132: 5283-93 PubMed GONUTS page
  17. Tsuji T et al. (2008) Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors. Development 135: 3859-69 PubMed GONUTS page
  18. 18.0 18.1 Lo PC et al. (2002) Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart. Dev Biol 251: 307-19 PubMed GONUTS page
  19. Lo PC & Frasch M (2003) Establishing A-P polarity in the embryonic heart tube: a conserved function of Hox genes in Drosophila and vertebrates? Trends Cardiovasc Med 13: 182-7 PubMed GONUTS page
  20. Freeland DE & Kuhn DT (1996) Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs. Mech Dev 56: 61-72 PubMed GONUTS page
  21. Chen EH et al. (2005) Allocation and specification of the genital disc precursor cells in Drosophila. Dev Biol 281: 270-85 PubMed GONUTS page
  22. Vachon G et al. (1992) Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71: 437-50 PubMed GONUTS page
  23. LaBeau EM et al. (2009) Bithorax complex genes control alary muscle patterning along the cardiac tube of Drosophila. Mech Dev 126: 478-86 PubMed GONUTS page
  24. Foronda D et al. (2006) Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. Development 133: 117-27 PubMed GONUTS page
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