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FB:aPKC
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | aPKC ( synonyms: Atypical PKC, Atypical protein kinase C, CG10261, CG30475, CG42783, DaPKC, PKCl,i, a-PKC, aPKC-zeta, aPKCzeta, alphaPKCzeta, apkc, atypical PKC, atypical Protein Kinase C, atypical Protein kinase C, atypical protein kinase C zeta, atypical-Protein Kinase C, daPKC, dapkc, l(2)k06403, pkc-3, pschur, psu ) | |
| Protein Name(s) | atypical protein kinase C, | |
| External Links | ||
| FB | FBgn0261854 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001738 |
morphogenesis of a polarized epithelium |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0002052 |
positive regulation of neuroblast proliferation |
FB:FBrf0207204 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003382 |
epithelial cell morphogenesis |
FB:FBrf0213424 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003371 |
P |
From FB |
||
| GO:0003382 |
epithelial cell morphogenesis |
FB:FBrf0213424 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0210663 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004697 |
protein kinase C activity |
FB:FBrf0130996 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0180375 |
IPI: Inferred from Physical Interaction |
FB:FBgn0067864 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0180375 |
IPI: Inferred from Physical Interaction |
FB:FBgn0259685 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0200619 |
IPI: Inferred from Physical Interaction |
FB:FBgn0030252 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
F |
From FB |
||
| GO:0005938 |
cell cortex |
FB:FBrf0174511 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From FB |
||
| GO:0007043 |
cell-cell junction assembly |
FB:FBrf0155643 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007163 |
establishment or maintenance of cell polarity |
FB:FBrf0159915 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007294 |
germarium-derived oocyte fate determination |
FB:FBrf0141721 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007309 |
oocyte axis specification |
FB:FBrf0158832 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007314 |
oocyte anterior/posterior axis specification |
FB:FBrf0203052 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002121 |
P |
From FB |
||
| GO:0007416 |
synapse assembly |
FB:FBrf0179422 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0188062 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007613 |
memory |
FB:FBrf0147172 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0155643 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016327 |
apicolateral plasma membrane |
FB:FBrf0180375 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
FB:FBrf0141669 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
FB:FBrf0209133 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016334 |
establishment or maintenance of polarity of follicular epithelium |
FB:FBrf0209133 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030011 |
maintenance of cell polarity |
FB:FBrf0167767 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035003 |
subapical complex |
FB:FBrf0155581 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0035003 |
subapical complex |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0035556 |
intracellular signal transduction |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0045167 |
asymmetric protein localization involved in cell fate determination |
FB:FBrf0157155 |
IPI: Inferred from Physical Interaction |
FB:FBgn0026192 |
P |
From FB |
||
| GO:0045176 |
apical protein localization |
FB:FBrf0156163 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0141669 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0207204 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0207940 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045179 |
apical cortex |
FB:FBrf0210663 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045186 |
zonula adherens assembly |
FB:FBrf0141282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045186 |
zonula adherens assembly |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045196 |
establishment or maintenance of neuroblast polarity |
FB:FBrf0141670 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045196 |
establishment or maintenance of neuroblast polarity |
FB:FBrf0209133 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0141670 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0158832 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0180375 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046667 |
compound eye retinal cell programmed cell death |
FB:FBrf0209035 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0055059 |
asymmetric neuroblast division |
FB:FBrf0155600 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0040080 |
P |
From FB |
||
| GO:0060446 |
branching involved in open tracheal system development |
FB:FBrf0215238 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0090163 |
establishment of epithelial cell planar polarity |
FB:FBrf0213424 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003371 |
P |
From FB |
||
| GO:0090163 |
establishment of epithelial cell planar polarity |
FB:FBrf0213424 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gibson MC & Perrimon N (2003) Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol 15: 747-52 PubMed GONUTS page
- ↑ 2.0 2.1 Chabu C & Doe CQ (2008) Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression. Development 135: 2739-46 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kaplan NA et al. (2011) Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. PLoS One 6: e18616 PubMed GONUTS page
- ↑ 4.0 4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 5.0 5.1 Morais-de-Sá E et al. (2010) aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. Cell 141: 509-23 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Sotillos S et al. (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol 166: 549-57 PubMed GONUTS page
- ↑ Liu R et al. (2008) Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development 135: 53-63 PubMed GONUTS page
- ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
- ↑ 9.0 9.1 Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
- ↑ Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
- ↑ Cox DN et al. (2001) Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary. Proc Natl Acad Sci U S A 98: 14475-80 PubMed GONUTS page
- ↑ 12.0 12.1 Ahringer J (2003) Control of cell polarity and mitotic spindle positioning in animal cells. Curr Opin Cell Biol 15: 73-81 PubMed GONUTS page
- ↑ Tian AG & Deng WM (2008) Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135: 463-71 PubMed GONUTS page
- ↑ Ruiz-Canada C et al. (2004) New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron 42: 567-80 PubMed GONUTS page
- ↑ Roegiers F et al. (2005) Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell 16: 3480-7 PubMed GONUTS page
- ↑ Drier EA et al. (2002) Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster. Nat Neurosci 5: 316-24 PubMed GONUTS page
- ↑ 17.0 17.1 Hong Y et al. (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414: 634-8 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Kim S et al. (2009) Kinase-activity-independent functions of atypical protein kinase C in Drosophila. J Cell Sci 122: 3759-71 PubMed GONUTS page
- ↑ Rolls MM et al. (2003) Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol 163: 1089-98 PubMed GONUTS page
- ↑ Médina E et al. (2002) Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell 94: 305-13 PubMed GONUTS page
- ↑ Betschinger J et al. (2003) The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 422: 326-30 PubMed GONUTS page
- ↑ Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
- ↑ Chabu C & Doe CQ (2009) Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Dev Biol 330: 399-405 PubMed GONUTS page
- ↑ Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
- ↑ 25.0 25.1 Bachmann A et al. (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-43 PubMed GONUTS page
- ↑ Ogawa H et al. (2009) Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. J Cell Sci 122: 3242-9 PubMed GONUTS page
- ↑ Cai Y et al. (2003) Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112: 51-62 PubMed GONUTS page
- ↑ Jones TA & Metzstein MM (2011) A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster. Genetics 189: 153-64 PubMed GONUTS page
