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FB:Xpd
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Xpd ( synonyms: CG9433, DhR3, DhXPD, DmXPD, ERCC2, XPD, XPD/ERCC2, l(2)SH2 2137, l(2)SH2137, lethal (2) SH2137, xpd ) | |
| Protein Name(s) | Xeroderma pigmentosum D, | |
| External Links | ||
| FB | FBgn0261850 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000439 |
core TFIIH complex |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
C |
From FB |
||
| GO:0000439 |
core TFIIH complex |
FB:FBrf0206304 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0001111 |
promoter clearance from RNA polymerase II promoter |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
P |
From FB |
||
| GO:0001113 |
transcriptional open complex formation at RNA polymerase II promoter |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
P |
From FB |
||
| GO:0003677 |
DNA binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0004386 |
helicase activity |
FB:FBrf0129923 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001945 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0201392 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0206304 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005675 |
holo TFIIH complex |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000973 |
C |
From FB |
||
| GO:0005675 |
holo TFIIH complex |
FB:FBrf0129705 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
C |
From FB |
||
| GO:0005675 |
holo TFIIH complex |
FB:FBrf0129705 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000973 |
C |
From FB |
||
| GO:0005703 |
polytene chromosome puff |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005705 |
polytene chromosome interband |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006289 |
nucleotide-excision repair |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
P |
From FB |
||
| GO:0006289 |
nucleotide-excision repair |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000973 |
P |
From FB |
||
| GO:0006289 |
nucleotide-excision repair |
FB:FBrf0202394 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
FB:FBrf0202394 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006367 |
transcription initiation from RNA polymerase II promoter |
FB:FBrf0129705 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3434 |
P |
From FB |
||
| GO:0006367 |
transcription initiation from RNA polymerase II promoter |
FB:FBrf0129705 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000973 |
P |
From FB |
||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007088 |
regulation of mitosis |
FB:FBrf0159708 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009411 |
response to UV |
FB:FBrf0108262 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0009411 |
response to UV |
FB:FBrf0135647 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0010972 |
negative regulation of G2/M transition of mitotic cell cycle |
FB:FBrf0159708 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0043141 |
ATP-dependent 5'-3' DNA helicase activity |
FB:FBrf0108262 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000973 |
F |
From FB |
||
| GO:0043141 |
ATP-dependent 5'-3' DNA helicase activity |
FB:FBrf0202394 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0051983 |
regulation of chromosome segregation |
FB:FBrf0210295 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Reynaud E et al. (1999) The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes. Mol Biol Cell 10: 1191-203 PubMed GONUTS page
- ↑ 2.0 2.1 Aguilar-Fuentes J et al. (2008) p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model. PLoS Genet 4: e1000253 PubMed GONUTS page
- ↑ Lasko P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J Cell Biol 150: F51-6 PubMed GONUTS page
- ↑ Fregoso M et al. (2007) DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Mol Cell Biol 27: 3640-50 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Aoyagi N & Wassarman DA (2000) Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. J Cell Biol 150: F45-50 PubMed GONUTS page
- ↑ 6.0 6.1 Chen J et al. (2003) Xpd/Ercc2 regulates CAK activity and mitotic progression. Nature 424: 228-32 PubMed GONUTS page
- ↑ Sandoval MT & Zurita M (2001) Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog. Antisense Nucleic Acid Drug Dev 11: 125-8 PubMed GONUTS page
- ↑ Li X et al. (2010) Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation. PLoS Genet 6: e1000876 PubMed GONUTS page
