FB:W

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	W ( synonyms: CG5123, HID, Head involution defective, Hid, Hid1, head involuted, head involution defect, head involution defective, head involution defective 1, head-involution defective, head-involution-defective, hid, hid1, his, l(3)05014, wrinkled, wrinkler )
Protein Name(s)	Wrinkled,
External Links
FB	FBgn0003997

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001700	embryonic development via the syncytial blastoderm	FB:FBrf0133206 PMID:11102824^[1]	TAS: Traceable Author Statement		P	From FB
	GO:0001700	embryonic development via the syncytial blastoderm	FB:FBrf0167429 PMID:14644196^[2]	TAS: Traceable Author Statement		P	From FB
	GO:0002165	instar larval or pupal development	FB:FBrf0054189 PMID:1752422^[3]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006915	apoptotic process	FB:FBrf0111320 PMID:10511707^[4]	TAS: Traceable Author Statement		P	From FB
	GO:0006915	apoptotic process	FB:FBrf0128885 PMID:10910336^[5]	TAS: Traceable Author Statement		P	From FB
	GO:0006915	apoptotic process	FB:FBrf0157341	NAS: Non-traceable Author Statement		P	From FB
	GO:0006915	apoptotic process	FB:FBrf0211820 PMID:20837774^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0105264 PMID:9814703^[7]	TAS: Traceable Author Statement		P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0111320 PMID:10511707^[4]	TAS: Traceable Author Statement		P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0111512 PMID:10481910^[8]	IGI: Inferred from Genetic Interaction	FB:FBgn0010501	P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0111512 PMID:10481910^[8]	IGI: Inferred from Genetic Interaction	FB:FBgn0260635	P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0124262	NAS: Non-traceable Author Statement		P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0162055 PMID:12919673^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006917	induction of apoptosis	FB:FBrf0167429 PMID:14644196^[2]	TAS: Traceable Author Statement		P	From FB
	GO:0007424	open tracheal system development	FB:FBrf0190123 PMID:16198330^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008219	cell death	FB:FBrf0190331 PMID:16280349^[11]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008258	head involution	FB:FBrf0054189 PMID:1752422^[3]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008258	head involution	FB:FBrf0124262	NAS: Non-traceable Author Statement		P	From FB
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	FB:FBrf0205772 PMID:18688282^[12]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0010114	response to red light	FB:FBrf0174852 PMID:14960620^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0012501	programmed cell death	FB:FBrf0082050 PMID:7622034^[14]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0012501	programmed cell death	FB:FBrf0093804 PMID:9144202^[15]	IGI: Inferred from Genetic Interaction	FB:FBgn0011706	P	From FB
	GO:0012501	programmed cell death	FB:FBrf0093804 PMID:9144202^[15]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0012501	programmed cell death	FB:FBrf0147184 PMID:12006672^[16]	TAS: Traceable Author Statement		P	From FB
	GO:0012501	programmed cell death	FB:FBrf0149068 PMID:12072176^[17]	TAS: Traceable Author Statement		P	From FB
	GO:0012501	programmed cell death	FB:FBrf0190156 PMID:16168982^[18]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0012502	induction of programmed cell death	FB:FBrf0192581 PMID:16485033^[19]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016567	protein ubiquitination	FB:FBrf0167429 PMID:14644196^[2]	TAS: Traceable Author Statement		P	From FB
	GO:0030162	regulation of proteolysis	FB:FBrf0167429 PMID:14644196^[2]	TAS: Traceable Author Statement		P	From FB
	GO:0035071	salivary gland cell autophagic cell death	FB:FBrf0126529	NAS: Non-traceable Author Statement		P	From FB
	GO:0035071	salivary gland cell autophagic cell death	FB:FBrf0157146	NAS: Non-traceable Author Statement		P	From FB
	GO:0035071	salivary gland cell autophagic cell death	FB:FBrf0179526 PMID:15150408^[20]	IGI: Inferred from Genetic Interaction	FB:FBgn0011706	P	From FB
	GO:0035071	salivary gland cell autophagic cell death	FB:FBrf0179526 PMID:15150408^[20]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0035072	ecdysone-mediated induction of salivary gland cell autophagic cell death	FB:FBrf0128149 PMID:10882130^[21]	IEP: Inferred from Expression Pattern		P	From FB
	GO:0035072	ecdysone-mediated induction of salivary gland cell autophagic cell death	FB:FBrf0133206 PMID:11102824^[1]	NAS: Non-traceable Author Statement		P	From FB
	GO:0035096	larval midgut cell programmed cell death	FB:FBrf0157146	NAS: Non-traceable Author Statement		P	From FB
	GO:0035096	larval midgut cell programmed cell death	FB:FBrf0179526 PMID:15150408^[20]	IGI: Inferred from Genetic Interaction	FB:FBgn0011706	P	From FB
	GO:0043065	positive regulation of apoptotic process	FB:FBrf0207165 PMID:19100727^[22]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0043153	entrainment of circadian clock by photoperiod	FB:FBrf0174852 PMID:14960620^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	FB:FBrf0192581 PMID:16485033^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0019972	P	From FB
	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	FB:FBrf0192581 PMID:16485033^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0024252	P	From FB
	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	FB:FBrf0192581 PMID:16485033^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0026404	P	From FB
	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	FB:FBrf0192581 PMID:16485033^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0028381	P	From FB
	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	FB:FBrf0192581 PMID:16485033^[19]	IGI: Inferred from Genetic Interaction	FB:FBgn0033051	P	From FB
	GO:0046620	regulation of organ growth	FB:FBrf0174444 PMID:15066286^[23]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0046667	compound eye retinal cell programmed cell death	FB:FBrf0141762 PMID:11735386^[24]	TAS: Traceable Author Statement		P	From FB
	GO:0046668	regulation of retinal cell programmed cell death	FB:FBrf0156100 PMID:12547518^[25]	NAS: Non-traceable Author Statement		P	From FB
	GO:0048800	antennal morphogenesis	FB:FBrf0179745 PMID:15464574^[26]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0048813	dendrite morphogenesis	FB:FBrf0192062 PMID:16980964^[27]	IMP: Inferred from Mutant Phenotype		P	From FB
NOT	GO:0045476	nurse cell apoptotic process	FB:FBrf0132269 PMID:11139280^[28]	TAS: Traceable Author Statement		P	From FB
NOT	GO:0045476	nurse cell apoptotic process	FB:FBrf0149068 PMID:12072176^[17]	TAS: Traceable Author Statement		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Buszczak M & Segraves WA (2000) Insect metamorphosis: out with the old, in with the new. Curr Biol 10: R830-3 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page
↑ ^3.0 ^3.1 Abbott MK & Lengyel JA (1991) Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. Genetics 129: 783-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
↑ De Laurenzi V & Melino G (2000) Apoptosis. The little devil of death. Nature 406: 135-6 PubMed GONUTS page
↑ Sandu C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J Cell Biol 190: 1039-52 PubMed GONUTS page
↑ Kurada P & White K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319-29 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98: 453-63 PubMed GONUTS page
↑ DeFalco TJ et al. (2003) Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell 5: 205-16 PubMed GONUTS page
↑ Guha A & Kornberg TB (2005) Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol 287: 192-200 PubMed GONUTS page
↑ Werz C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132: 5343-52 PubMed GONUTS page
↑ Moon NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4: e1000153 PubMed GONUTS page
↑ ^13.0 ^13.1 Klarsfeld A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci 24: 1468-77 PubMed GONUTS page
↑ Grether ME et al. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev 9: 1694-708 PubMed GONUTS page
↑ ^15.0 ^15.1 Zhou L et al. (1997) Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A 94: 5131-6 PubMed GONUTS page
↑ Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
↑ ^17.0 ^17.1 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
↑ Rodriguez Moncalvo VG & Campos AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev Biol 286: 549-58 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Yin VP & Thummel CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc Natl Acad Sci U S A 101: 8022-7 PubMed GONUTS page
↑ Jiang C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol Cell 5: 445-55 PubMed GONUTS page
↑ Tanaka-Matakatsu M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326: 347-56 PubMed GONUTS page
↑ de la Cova C et al. (2004) Drosophila myc regulates organ size by inducing cell competition. Cell 117: 107-16 PubMed GONUTS page
↑ Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page
↑ Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page
↑ Cullen K & McCall K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev Biol 275: 82-92 PubMed GONUTS page
↑ Williams DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 9: 1234-6 PubMed GONUTS page
↑ Buszczak M & Cooley L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ 7: 1071-4 PubMed GONUTS page

[PMID:11102824-0] 1.0 ^1.1 Buszczak M & Segraves WA (2000) Insect metamorphosis: out with the old, in with the new. Curr Biol 10: R830-3 PubMed GONUTS page

[PMID:14644196-1] 2.0 ^2.1 ^2.2 ^2.3 Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page

[PMID:1752422-2] 3.0 ^3.1 Abbott MK & Lengyel JA (1991) Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. Genetics 129: 783-9 PubMed GONUTS page

[PMID:10511707-3] 4.0 ^4.1 Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page

[PMID:10910336-4] De Laurenzi V & Melino G (2000) Apoptosis. The little devil of death. Nature 406: 135-6 PubMed GONUTS page

[PMID:20837774-5] Sandu C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J Cell Biol 190: 1039-52 PubMed GONUTS page

[PMID:9814703-6] Kurada P & White K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319-29 PubMed GONUTS page

[PMID:10481910-7] 8.0 ^8.1 Wang SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98: 453-63 PubMed GONUTS page

[PMID:12919673-8] DeFalco TJ et al. (2003) Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell 5: 205-16 PubMed GONUTS page

[PMID:16198330-9] Guha A & Kornberg TB (2005) Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol 287: 192-200 PubMed GONUTS page

[PMID:16280349-10] Werz C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132: 5343-52 PubMed GONUTS page

[PMID:18688282-11] Moon NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4: e1000153 PubMed GONUTS page

[PMID:14960620-12] 13.0 ^13.1 Klarsfeld A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci 24: 1468-77 PubMed GONUTS page

[PMID:7622034-13] Grether ME et al. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev 9: 1694-708 PubMed GONUTS page

[PMID:9144202-14] 15.0 ^15.1 Zhou L et al. (1997) Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A 94: 5131-6 PubMed GONUTS page

[PMID:12006672-15] Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page

[PMID:12072176-16] 17.0 ^17.1 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page

[PMID:16168982-17] Rodriguez Moncalvo VG & Campos AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev Biol 286: 549-58 PubMed GONUTS page

[PMID:16485033-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page

[PMID:15150408-19] 20.0 ^20.1 ^20.2 Yin VP & Thummel CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc Natl Acad Sci U S A 101: 8022-7 PubMed GONUTS page

[PMID:10882130-20] Jiang C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol Cell 5: 445-55 PubMed GONUTS page

[PMID:19100727-21] Tanaka-Matakatsu M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326: 347-56 PubMed GONUTS page

[PMID:15066286-22] Cova C et al. (2004) Drosophila myc regulates organ size by inducing cell competition. Cell 117: 107-16 PubMed GONUTS page

[PMID:11735386-23] Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page

[PMID:12547518-24] Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page

[PMID:15464574-25] Cullen K & McCall K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev Biol 275: 82-92 PubMed GONUTS page

[PMID:16980964-26] Williams DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 9: 1234-6 PubMed GONUTS page

[PMID:11139280-27] Buszczak M & Cooley L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ 7: 1071-4 PubMed GONUTS page

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FB:W

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Notes

References

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