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FB:Top2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Top2 ( synonyms: CG10223, CHRAC, DNA topoisomerase II, TOP2, TOPO II, TOPOII, TopII, Topo II, TopoII, Topoisomerase II, dCHRAC, dTopoII, top2, topo II, topoII, topoisomerase II, type II DNA topoisomerase, type II topoisomerase ) | |
| Protein Name(s) | Topoisomerase 2, | |
| External Links | ||
| FB | FBgn0003732 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000182 |
rDNA binding |
FB:FBrf0194408 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0000400 |
four-way junction DNA binding |
FB:FBrf0051671 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0000400 |
four-way junction DNA binding |
FB:FBrf0127508 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0000819 |
sister chromatid segregation |
FB:FBrf0167777 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0000819 |
sister chromatid segregation |
FB:FBrf0167778 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0126830 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003696 |
satellite DNA binding |
FB:FBrf0194408 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003729 |
mRNA binding |
FB:FBrf0126830 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
FB:FBrf0050127 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
FB:FBrf0123612 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
FB:FBrf0126830 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001154 |
F |
From FB |
||
| GO:0005625 |
soluble fraction |
FB:FBrf0126830 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005626 |
insoluble fraction |
FB:FBrf0126830 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0050127 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0108679 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0123612 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0128696 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0132311 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005694 |
chromosome |
FB:FBrf0128696 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006265 |
DNA topological change |
FB:FBrf0050127 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006265 |
DNA topological change |
FB:FBrf0127508 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006342 |
chromatin silencing |
FB:FBrf0194408 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007052 |
mitotic spindle organization |
FB:FBrf0200397 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0126830 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0207149 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007076 |
mitotic chromosome condensation |
FB:FBrf0200397 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007095 |
mitotic cell cycle G2/M transition DNA damage checkpoint |
FB:FBrf0212700 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261530 |
P |
From FB |
||
| GO:0007126 |
meiosis |
FB:FBrf0126830 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008623 |
chromatin accessibility complex |
FB:FBrf0097684 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0051310 |
metaphase plate congression |
FB:FBrf0167777 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
|
NOT |
GO:0008623 |
chromatin accessibility complex |
FB:FBrf0138380 |
IDA: Inferred from Direct Assay |
C |
From FB |
||
|
NOT |
GO:0016590 |
ACF complex |
FB:FBrf0095281 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Blattes R et al. (2006) Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J 25: 2397-408 PubMed GONUTS page
- ↑ Zechiedrich EL & Osheroff N (1990) Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. EMBO J 9: 4555-62 PubMed GONUTS page
- ↑ 3.0 3.1 Strick TR et al. (2000) Single-molecule analysis of DNA uncoiling by a type II topoisomerase. Nature 404: 901-4 PubMed GONUTS page
- ↑ 4.0 4.1 Chang CJ et al. (2003) RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate. J Cell Sci 116: 4715-26 PubMed GONUTS page
- ↑ Coelho PA et al. (2003) Condensin-dependent localisation of topoisomerase II to an axial chromosomal structure is required for sister chromatid resolution during mitosis. J Cell Sci 116: 4763-76 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Rzepecki R & Fisher PA (2000) During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain. J Cell Sci 113 ( Pt 9): 1635-47 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Lee MP et al. (1989) Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II. J Biol Chem 264: 13510-8 PubMed GONUTS page
- ↑ 8.0 8.1 Zhang CX et al. (2000) Essential functions of DNA topoisomerase I in Drosophila melanogaster. Dev Biol 222: 27-40 PubMed GONUTS page
- ↑ Gemkow MJ et al. (2001) Developmental regulation of DNA-topoisomerases during Drosophila embryogenesis. Exp Cell Res 262: 114-21 PubMed GONUTS page
- ↑ 10.0 10.1 Goshima G et al. (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316: 417-21 PubMed GONUTS page
- ↑ Ducat D et al. (2008) Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell 19: 3097-110 PubMed GONUTS page
- ↑ Kondo S & Perrimon N (2011) A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Sci Signal 4: rs1 PubMed GONUTS page
- ↑ Varga-Weisz PD et al. (1997) Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Nature 388: 598-602 PubMed GONUTS page
- ↑ Eberharter A et al. (2001) Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling. EMBO J 20: 3781-8 PubMed GONUTS page
- ↑ Ito T et al. (1997) ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90: 145-55 PubMed GONUTS page
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