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FB:Tl

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Tl ( synonyms: CG5490, CT17414, EP(3)1051, EP1051, Fs(1)Tl, Fs(3)Tl, Protein toll precursor, T1, TL, TOL, Toll receptor, Toll-1, Toll1, dToll, dToll1, mat(3)9, mel(3)10, mel(3)9, tl, toll, toll receptor, toll-1 )
Protein Name(s) Toll,
External Links
FB FBgn0262473

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000910

cytokinesis

FB:FBrf0167741
PMID:14527345[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0110978
PMID:10449356[2]

NAS: Non-traceable Author Statement

F

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0133282

NAS: Non-traceable Author Statement

F

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR004075

F

From FB

GO:0005515

protein binding

FB:FBrf0193565
PMID:16782008[3]

IPI: Inferred from Physical Interaction

FB:FBgn0001990

F

From FB

GO:0005515

protein binding

FB:FBrf0205200
PMID:18347020[4]

IPI: Inferred from Physical Interaction

FB:FBgn0003495

F

From FB

GO:0005886

plasma membrane

FB:FBrf0210737
PMID:20404143[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0123469

NAS: Non-traceable Author Statement

C

From FB

GO:0006952

defense response

FB:FBrf0127230
PMID:10793472[6]

TAS: Traceable Author Statement

P

From FB

GO:0006952

defense response

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0006955

immune response

FB:FBrf0128774
PMID:10878576[7]

TAS: Traceable Author Statement

P

From FB

GO:0006955

immune response

FB:FBrf0134783
PMID:11252751[8]

TAS: Traceable Author Statement

P

From FB

GO:0006955

immune response

FB:FBrf0141086
PMID:11135568[9]

TAS: Traceable Author Statement

P

From FB

GO:0006963

positive regulation of antibacterial peptide biosynthetic process

FB:FBrf0100121
PMID:9405661[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006967

positive regulation of antifungal peptide biosynthetic process

FB:FBrf0100121
PMID:9405661[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006967

positive regulation of antifungal peptide biosynthetic process

FB:FBrf0110270
PMID:10369678[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007165

signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000157
InterPro:IPR004075

P

From FB

GO:0007352

zygotic specification of dorsal/ventral axis

FB:FBrf0179043
PMID:15199954[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0007416

synapse assembly

FB:FBrf0127344
PMID:10699982[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007507

heart development

FB:FBrf0188114
PMID:15870289[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0110978
PMID:10449356[2]

NAS: Non-traceable Author Statement

P

From FB

GO:0008063

Toll signaling pathway

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0009617

response to bacterium

FB:FBrf0155688
PMID:12530956[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0009620

response to fungus

FB:FBrf0132053
PMID:11104525[16]

TAS: Traceable Author Statement

P

From FB

GO:0009620

response to fungus

FB:FBrf0141068
PMID:11283698[17]

TAS: Traceable Author Statement

P

From FB

GO:0009880

embryonic pattern specification

FB:FBrf0141068
PMID:11283698[17]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0127230
PMID:10793472[6]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0141086
PMID:11135568[9]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0141281
PMID:11700289[18]

NAS: Non-traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0193565
PMID:16782008[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016021

integral to membrane

FB:FBrf0133282

NAS: Non-traceable Author Statement

C

From FB

GO:0016201

synaptic target inhibition

FB:FBrf0210991
PMID:20504957[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0019730

antimicrobial humoral response

FB:FBrf0090665
PMID:8808632[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0013983

P

From FB

GO:0019732

antifungal humoral response

FB:FBrf0090665
PMID:8808632[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0019955

cytokine binding

FB:FBrf0161598
PMID:12888789[21]

TAS: Traceable Author Statement

F

From FB

GO:0030097

hemopoiesis

FB:FBrf0127230
PMID:10793472[6]

TAS: Traceable Author Statement

P

From FB

GO:0031224

intrinsic to membrane

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR004075

C

From FB

GO:0033565

ESCRT-0 complex

FB:FBrf0210737
PMID:20404143[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0035007

regulation of melanization defense response

FB:FBrf0161623

TAS: Traceable Author Statement

P

From FB

GO:0035172

hemocyte proliferation

FB:FBrf0167476
PMID:14602069[22]

TAS: Traceable Author Statement

P

From FB

GO:0035172

hemocyte proliferation

FB:FBrf0187386
PMID:15882582[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043234

protein complex

FB:FBrf0205200
PMID:18347020[4]

IPI: Inferred from Physical Interaction

FB:FBgn0003495

C

From FB

GO:0045087

innate immune response

FB:FBrf0161598
PMID:12888789[21]

TAS: Traceable Author Statement

P

From FB

GO:0045087

innate immune response

FB:FBrf0167392
PMID:14557290[24]

TAS: Traceable Author Statement

P

From FB

GO:0045087

innate immune response

FB:FBrf0188361
PMID:15797611[25]

NAS: Non-traceable Author Statement

P

From FB

GO:0045087

innate immune response

FB:FBrf0207383
PMID:18583479[26]

IDA: Inferred from Direct Assay

P

From FB

GO:0045610

regulation of hemocyte differentiation

FB:FBrf0180639
PMID:15381778[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050830

defense response to Gram-positive bacterium

FB:FBrf0161598
PMID:12888789[21]

TAS: Traceable Author Statement

P

From FB

GO:0050830

defense response to Gram-positive bacterium

FB:FBrf0167392
PMID:14557290[24]

TAS: Traceable Author Statement

P

From FB

GO:0050830

defense response to Gram-positive bacterium

FB:FBrf0179043
PMID:15199954[12]

TAS: Traceable Author Statement

P

From FB

GO:0050832

defense response to fungus

FB:FBrf0161598
PMID:12888789[21]

TAS: Traceable Author Statement

P

From FB

GO:0050832

defense response to fungus

FB:FBrf0167392
PMID:14557290[24]

TAS: Traceable Author Statement

P

From FB

GO:0050832

defense response to fungus

FB:FBrf0174342
PMID:15032585[28]

TAS: Traceable Author Statement

P

From FB

GO:0050832

defense response to fungus

FB:FBrf0179043
PMID:15199954[12]

TAS: Traceable Author Statement

P

From FB

GO:0070976

TIR domain binding

FB:FBrf0141679
PMID:11743586[29]

IPI: Inferred from Physical Interaction

FB:FBgn0033402

F

From FB

colocalizes_with

GO:0005886

plasma membrane

FB:FBrf0206701
PMID:19154721[30]

IDA: Inferred from Direct Assay

C

From FB


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  2. ↑ 2.0 2.1 van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page
  3. ↑ 3.0 3.1 Chen LY et al. (2006) Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Curr Biol 16: 1183-93 PubMed GONUTS page
  4. ↑ 4.0 4.1 Gangloff M et al. (2008) Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle. J Biol Chem 283: 14629-35 PubMed GONUTS page
  5. ↑ 5.0 5.1 Huang HR et al. (2010) Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A 107: 8322-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page
  7. ↑ Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
  8. ↑ Schneider D (2000) Using Drosophila as a model insect. Nat Rev Genet 1: 218-26 PubMed GONUTS page
  9. ↑ 9.0 9.1 Beutler B & Poltorak A (2001) Toll we meet again.... Nat Immunol 2: 9-10 PubMed GONUTS page
  10. ↑ 10.0 10.1 Lemaitre B et al. (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci U S A 94: 14614-9 PubMed GONUTS page
  11. ↑ Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
  13. ↑ Suzuki E et al. (2000) The ultrastructural interactions of identified pre- and postsynaptic cells during synaptic target recognition in Drosophila embryos. J Neurobiol 42: 448-59 PubMed GONUTS page
  14. ↑ Wang J et al. (2005) Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol 25: 4200-10 PubMed GONUTS page
  15. ↑ Silverman N (2003) Flies kNOw how to signal. Dev Cell 4: 5-6 PubMed GONUTS page
  16. ↑ Medzhitov R & Janeway Jr C (2000) Fly immunity: great expectations. Genome Biol 1: REVIEWS106 PubMed GONUTS page
  17. ↑ 17.0 17.1 Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
  18. ↑ Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
  19. ↑ Inaki M et al. (2010) Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity. Development 137: 2139-46 PubMed GONUTS page
  20. ↑ 20.0 20.1 Lemaitre B et al. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-83 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 21.3 Underhill D (2003) Toll gets tied in a knot. Nat Immunol 4: 723-4 PubMed GONUTS page
  22. ↑ Evans CJ et al. (2003) Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev Cell 5: 673-90 PubMed GONUTS page
  23. ↑ Huang L et al. (2005) The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Dev Biol 280: 407-20 PubMed GONUTS page
  24. ↑ 24.0 24.1 24.2 Janssens S & Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16: 637-46 PubMed GONUTS page
  25. ↑ Kwiatkowski DP (2005) The complexity of genetic variation in a simple immune system. Trends Genet 21: 197-9 PubMed GONUTS page
  26. ↑ Chamilos G et al. (2008) Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A 105: 9367-72 PubMed GONUTS page
  27. ↑ Zettervall CJ et al. (2004) A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A 101: 14192-7 PubMed GONUTS page
  28. ↑ Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page
  29. ↑ Tauszig-Delamasure S et al. (2002) Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat Immunol 3: 91-7 PubMed GONUTS page
  30. ↑ Mavrakis M et al. (2009) Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo. Dev Cell 16: 93-104 PubMed GONUTS page
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