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FB:Timp

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Timp ( synonyms: CG6281, DTIMP, Dtimp, TIMP, dTIMP, timp, tissue inhibitor of metalloproteases, tissue inhibitor of metalloproteinases )
Protein Name(s) Tissue inhibitor of metalloproteases,
External Links
FB FBgn0025879

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005576

extracellular region

FB:FBrf0108259
PMID:10198170[1]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0007155

cell adhesion

FB:FBrf0129829
PMID:10961449[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0209232
PMID:19751719[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007472

wing disc morphogenesis

FB:FBrf0192456
PMID:16962574[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008191

metalloendopeptidase inhibitor activity

FB:FBrf0108259
PMID:10198170[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0008191

metalloendopeptidase inhibitor activity

FB:FBrf0113545

NAS: Non-traceable Author Statement

F

From FB

GO:0008191

metalloendopeptidase inhibitor activity

FB:FBrf0167341
PMID:14567681[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0030425

dendrite

FB:FBrf0191447
PMID:16210248[6]

IMP: Inferred from Mutant Phenotype

C

From FB

GO:0035202

tracheal pit formation in open tracheal system

FB:FBrf0209232
PMID:19751719[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042331

phototaxis

FB:FBrf0129829
PMID:10961449[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048526

imaginal disc-derived wing expansion

FB:FBrf0192456
PMID:16962574[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060232

delamination

FB:FBrf0192456
PMID:16962574[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0071711

basement membrane organization

FB:FBrf0209232
PMID:19751719[3]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Pohar N et al. (1999) Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human. Genomics 57: 293-6 PubMed GONUTS page
  2. 2.0 2.1 Godenschwege TA et al. (2000) Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila. Eur J Cell Biol 79: 495-501 PubMed GONUTS page
  3. 3.0 3.1 3.2 Guha A et al. (2009) Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol 335: 317-26 PubMed GONUTS page
  4. 4.0 4.1 4.2 Kiger JA Jr et al. (2007) Tissue remodeling during maturation of the Drosophila wing. Dev Biol 301: 178-91 PubMed GONUTS page
  5. Wei S et al. (2003) Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3. Biochemistry 42: 12200-7 PubMed GONUTS page
  6. Kuo CT et al. (2005) Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc Natl Acad Sci U S A 102: 15230-5 PubMed GONUTS page
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