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FB:Thor
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Thor ( synonyms: 153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Eif4e-binding protein, Phas1, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, d4e-bp, d4eBP, dthor, eIF-4E-binding protein, eIF4E-BP, eif4e-binding protein 4EBP, eukaryotic initiation factor 4E binding protein, eukaryotic initiation factor 4E-binding protein, eukaryotic translation initiation factor 4E binding protein, eukaryotic translation initiation factor 4E-binding protein, insulin-stimulated eIF-4E binding protein, l(2)06270, l(2)k07736, l(2)k13517, lethal (2) 06270, pp20, thor ) | |
| Protein Name(s) | Thor, | |
| External Links | ||
| FB | FBgn0261560 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001558 |
regulation of cell growth |
FB:FBrf0137059 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010379 |
P |
From FB |
||
| GO:0001558 |
regulation of cell growth |
FB:FBrf0137059 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015279 |
P |
From FB |
||
| GO:0001558 |
regulation of cell growth |
FB:FBrf0137059 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006641 |
triglyceride metabolic process |
FB:FBrf0187599 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006950 |
response to stress |
FB:FBrf0162177 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0128398 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0128398 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0129335 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006979 |
response to oxidative stress |
FB:FBrf0187600 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0101054 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0128398 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:3288 |
F |
From FB |
||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0129335 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0137059 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0184136 |
IPI: Inferred from Physical Interaction |
FB:FBgn0015218 |
F |
From FB |
||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0184136 |
IPI: Inferred from Physical Interaction |
FB:FBgn0035709 |
F |
From FB |
||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0184136 |
IPI: Inferred from Physical Interaction |
FB:FBgn0035823 |
F |
From FB |
||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0184136 |
IPI: Inferred from Physical Interaction |
FB:FBgn0035860 |
F |
From FB |
||
| GO:0008190 |
eukaryotic initiation factor 4E binding |
FB:FBrf0184136 |
IPI: Inferred from Physical Interaction |
FB:FBgn0040368 |
F |
From FB |
||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0209084 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0019731 |
antibacterial humoral response |
FB:FBrf0128398 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042594 |
response to starvation |
FB:FBrf0187600 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042594 |
response to starvation |
FB:FBrf0209084 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0159230 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045947 |
negative regulation of translational initiation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0070129 |
regulation of mitochondrial translation |
FB:FBrf0209084 |
IDA: Inferred from Direct Assay |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Miron M et al. (2001) The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol 3: 596-601 PubMed GONUTS page
- ↑ Teleman AA et al. (2005) 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev 19: 1844-8 PubMed GONUTS page
- ↑ Jünger MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: 20 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Bernal A & Kimbrell DA (2000) Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci U S A 97: 6019-24 PubMed GONUTS page
- ↑ 5.0 5.1 Tettweiler G et al. (2005) Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev 19: 1840-3 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Hernández G et al. (2005) Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila. Mech Dev 122: 529-43 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Zid BM et al. (2009) 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139: 149-60 PubMed GONUTS page
- ↑ Jacinto E & Hall MN (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4: 117-26 PubMed GONUTS page
- ↑ Cully M et al. (2010) A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol 30: 481-95 PubMed GONUTS page
