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FB:Syt1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Syt1 ( synonyms: CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Droso1, Dsyt2, SYT, SYT I, SYT1, Synaptotagmin, Synaptotagmin I, Synaptotagmin-I, Synaptotagmin1, SynaptotagminI, Syt, Syt 1, Syt I, Syt-1, SytI, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, synaptotagmin, synaptotagmin 1, synaptotagmin I, synaptotagmin-1, syt, syt 1, syt I, syt-1, syt1, sytI ) | |
| Protein Name(s) | Synaptotagmin 1, | |
| External Links | ||
| FB | FBgn0004242 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005215 |
transporter activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005509 |
calcium ion binding |
FB:FBrf0077252 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0131377 |
IPI: Inferred from Physical Interaction |
FB:FBgn0016975 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0131377 |
IPI: Inferred from Physical Interaction |
FB:FBgn0016976 |
F |
From FB |
||
| GO:0005544 |
calcium-dependent phospholipid binding |
FB:FBrf0108883 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0006887 |
exocytosis |
FB:FBrf0078115 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007269 |
neurotransmitter secretion |
FB:FBrf0064585 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007269 |
neurotransmitter secretion |
FB:FBrf0077252 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007269 |
neurotransmitter secretion |
FB:FBrf0108883 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007317 |
regulation of pole plasm oskar mRNA localization |
FB:FBrf0125279 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008021 |
synaptic vesicle |
FB:FBrf0123757 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0008021 |
synaptic vesicle |
FB:FBrf0129948 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0008021 |
synaptic vesicle |
FB:FBrf0187820 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0008021 |
synaptic vesicle |
FB:FBrf0195323 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0008345 |
larval locomotory behavior |
FB:FBrf0077252 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0123757 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0016079 |
synaptic vesicle exocytosis |
FB:FBrf0129948 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0016192 |
vesicle-mediated transport |
FB:FBrf0077249 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016192 |
vesicle-mediated transport |
FB:FBrf0108281 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016192 |
vesicle-mediated transport |
FB:FBrf0108883 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016192 |
vesicle-mediated transport |
FB:FBrf0125279 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030285 |
integral to synaptic vesicle membrane |
FB:FBrf0077252 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0031594 |
neuromuscular junction |
FB:FBrf0139814 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0048488 |
synaptic vesicle endocytosis |
FB:FBrf0173116 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048488 |
synaptic vesicle endocytosis |
FB:FBrf0195323 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0048489 |
synaptic vesicle transport |
FB:FBrf0123757 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0048791 |
calcium ion-dependent exocytosis of neurotransmitter |
FB:FBrf0201175 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050803 |
regulation of synapse structure and activity |
FB:FBrf0190008 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Littleton JT et al. (1994) Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A 91: 10888-92 PubMed GONUTS page
- ↑ 2.0 2.1 Phillips AM et al. (2000) The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin. J Neurosci 20: 8254-61 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Littleton JT et al. (1999) Mechanisms of neurotransmitter release. Int Rev Neurobiol 43: 139-61 PubMed GONUTS page
- ↑ Littleton JT et al. (1993) Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Cell 74: 1125-34 PubMed GONUTS page
- ↑ 5.0 5.1 Ruden DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev Biol 218: 314-25 PubMed GONUTS page
- ↑ 6.0 6.1 Littleton JT (2000) A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila. J Cell Biol 150: F77-82 PubMed GONUTS page
- ↑ Narayanan R et al. (2005) An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol 169: 117-26 PubMed GONUTS page
- ↑ 8.0 8.1 Poskanzer KE et al. (2006) Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron 50: 49-62 PubMed GONUTS page
- ↑ Broadie K et al. (1994) Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proc Natl Acad Sci U S A 91: 10727-31 PubMed GONUTS page
- ↑ Stimson DT & Ramaswami M (1999) Vesicle recycling at the Drosophila neuromuscular junction. Int Rev Neurobiol 43: 163-89 PubMed GONUTS page
- ↑ Loewen CA et al. (2001) Drosophila synaptotagmin I null mutants survive to early adulthood. Genesis 31: 30-6 PubMed GONUTS page
- ↑ Poskanzer KE et al. (2003) Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature 426: 559-63 PubMed GONUTS page
- ↑ Saraswati S et al. (2007) Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 104: 14122-7 PubMed GONUTS page
- ↑ Dickman DK et al. (2006) Altered synaptic development and active zone spacing in endocytosis mutants. Curr Biol 16: 591-8 PubMed GONUTS page
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