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FB:Stat92E
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Stat92E ( synonyms: CG4257, D-STAT, D-Stat, D-stat, D-stat/stat92E, DRODSRC, DSRC, DSTAT, DmSTAT, Dstat, Dstat 92E, Dstat92E, Marelle, SD-stat, STAT, STAT 92E, STAT92E, Signal-transducer and activator of transcription protein, Stat, Stat1alpha-like, Stat92, d-STAT, dSTAT, dSTAT92E, dSTAT92E/marelle, dstat, l(3)06346, l(3)j6C8, marelle, mrL, mrl, mrl stat92E, pSTAT, signal transducer and activator of transcription, signal transducers and activator of transcription, stat, stat92, stat92E, stat92e, stat(92E) ) | |
| Protein Name(s) | Signal-transducer and activator of transcription protein at 92E, | |
| External Links | ||
| FB | FBgn0016917 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0128538 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0086463 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:11366 |
F |
From FB |
||
| GO:0003677 |
DNA binding |
FB:FBrf0086463 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:11368 |
F |
From FB |
||
| GO:0003677 |
DNA binding |
FB:FBrf0141375 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0151864 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004871 |
signal transducer activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001217 |
F |
From FB |
||
| GO:0005509 |
calcium ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0155684 |
IPI: Inferred from Physical Interaction |
FB:FBgn0004107 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0155684 |
IPI: Inferred from Physical Interaction |
FB:FBgn0016131 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
MGI:MGI:103035 |
C |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0124271 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0128538 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0162064 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0178966 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0162064 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0178966 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0124271 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001217 |
P |
From FB |
||
| GO:0006952 |
defense response |
FB:FBrf0128538 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006959 |
humoral immune response |
FB:FBrf0178966 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007259 |
JAK-STAT cascade |
FB:FBrf0124271 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007259 |
JAK-STAT cascade |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007259 |
JAK-STAT cascade |
FB:FBrf0151864 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0141417 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0151864 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0207765 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007350 |
blastoderm segmentation |
FB:FBrf0141375 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007379 |
segment specification |
FB:FBrf0190126 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007399 |
nervous system development |
FB:FBrf0167843 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007424 |
open tracheal system development |
FB:FBrf0167843 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007425 |
epithelial cell fate determination, open tracheal system |
FB:FBrf0167264 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007442 |
hindgut morphogenesis |
FB:FBrf0151948 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007442 |
hindgut morphogenesis |
FB:FBrf0167843 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007455 |
eye-antennal disc morphogenesis |
FB:FBrf0193730 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0141375 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007530 |
sex determination |
FB:FBrf0141375 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007538 |
primary sex determination |
FB:FBrf0128151 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007616 |
long-term memory |
FB:FBrf0213703 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008284 |
positive regulation of cell proliferation |
FB:FBrf0212840 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008348 |
negative regulation of antimicrobial humoral response |
FB:FBrf0201134 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0014018 |
P |
From FB |
||
| GO:0008348 |
negative regulation of antimicrobial humoral response |
FB:FBrf0201134 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0017145 |
stem cell division |
FB:FBrf0141754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019827 |
stem cell maintenance |
FB:FBrf0141753 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030097 |
hemopoiesis |
FB:FBrf0141375 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
FB:FBrf0193730 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030713 |
ovarian follicle cell stalk formation |
FB:FBrf0167471 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030718 |
germ-line stem cell maintenance |
FB:FBrf0179144 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030720 |
oocyte localization involved in germarium-derived egg chamber formation |
FB:FBrf0167471 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035019 |
somatic stem cell maintenance |
FB:FBrf0210092 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035167 |
larval lymph gland hemopoiesis |
FB:FBrf0208909 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035171 |
lamellocyte differentiation |
FB:FBrf0167476 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0035171 |
lamellocyte differentiation |
FB:FBrf0178966 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0035172 |
hemocyte proliferation |
FB:FBrf0167476 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046425 |
regulation of JAK-STAT cascade |
FB:FBrf0212202 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048103 |
somatic stem cell division |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0144804 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0151864 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0167471 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0141375 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0071222 |
cellular response to lipopolysaccharide |
FB:FBrf0128538 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0071481 |
cellular response to X-ray |
FB:FBrf0205996 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Kwon EJ et al. (2000) Transcriptional regulation of the Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response. J Biol Chem 275: 19824-30 PubMed GONUTS page
- ↑ 2.0 2.1 Hou XS et al. (1996) Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 84: 411-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Luo H & Dearolf CR (2001) The JAK/STAT pathway and Drosophila development. Bioessays 23: 1138-47 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Hombría JC & Brown S (2002) The fertile field of Drosophila Jak/STAT signalling. Curr Biol 12: R569-75 PubMed GONUTS page
- ↑ 5.0 5.1 Chen X et al. (2003) Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev Cell 4: 179-90 PubMed GONUTS page
- ↑ 6.0 6.1 Agaisse H et al. (2003) Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell 5: 441-50 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Agaisse H & Perrimon N (2004) The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev 198: 72-82 PubMed GONUTS page
- ↑ Silver DL & Montell DJ (2001) Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 107: 831-41 PubMed GONUTS page
- ↑ Jang AC et al. (2009) Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. Nat Cell Biol 11: 569-79 PubMed GONUTS page
- ↑ Hombría JC et al. (2005) Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Dev Biol 288: 420-33 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Li J et al. (2003) Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev 120: 1455-68 PubMed GONUTS page
- ↑ Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
- ↑ Johansen KA et al. (2003) Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development 130: 135-45 PubMed GONUTS page
- ↑ 14.0 14.1 Ekas LA et al. (2006) JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development 133: 4721-9 PubMed GONUTS page
- ↑ Jinks TM et al. (2000) The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Mol Cell 5: 581-7 PubMed GONUTS page
- ↑ Copf T et al. (2011) Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc Natl Acad Sci U S A 108: 8059-64 PubMed GONUTS page
- ↑ Buchon N et al. (2010) Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 8: 152 PubMed GONUTS page
- ↑ 18.0 18.1 Kim LK et al. (2007) Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol 5: e238 PubMed GONUTS page
- ↑ Tulina N & Matunis E (2001) Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science 294: 2546-9 PubMed GONUTS page
- ↑ Kiger AA et al. (2001) Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science 294: 2542-5 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Torres IL et al. (2003) A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell 5: 547-58 PubMed GONUTS page
- ↑ Brawley C & Matunis E (2004) Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo. Science 304: 1331-4 PubMed GONUTS page
- ↑ Singh SR et al. (2010) Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. J Cell Physiol 223: 500-10 PubMed GONUTS page
- ↑ Gao H et al. (2009) Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency. Mol Cell Biol 29: 6086-96 PubMed GONUTS page
- ↑ 25.0 25.1 Evans CJ et al. (2003) Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev Cell 5: 673-90 PubMed GONUTS page
- ↑ 26.0 26.1 Lin H (2002) The stem-cell niche theory: lessons from flies. Nat Rev Genet 3: 931-40 PubMed GONUTS page
- ↑ Kallio J et al. (2010) Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. FASEB J 24: 4467-79 PubMed GONUTS page
- ↑ Baksa K et al. (2002) The Drosophila STAT protein, stat92E, regulates follicle cell differentiation during oogenesis. Dev Biol 243: 166-75 PubMed GONUTS page
- ↑ Betz A et al. (2008) STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. Proc Natl Acad Sci U S A 105: 13805-10 PubMed GONUTS page
