Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

FB:Sos

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Sos ( synonyms: 2.3, 34Ea, BG:DS00941.4, CG7793, E(sev)2A, E(var)189, EK2-8, EY2-3, SOS, Son-of-sevenless, Sos1, Su(tor)2-2, br24, br25, dSos, dme-SOS, l(2)34Ea, l(2)Sos, l(2)br24, l(2)br25, l(2)k05224, l(2)k06321, lethal 24 in the black-reduced region, lethal 25 in the black-reduced region, son of sevenless, son-of-sevenless, sos )
Protein Name(s) Son of sevenless,
External Links
FB FBgn0001965

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR007125
InterPro:IPR009072

F

From FB

GO:0005088

Ras guanyl-nucleotide exchange factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07889

F

From FB

GO:0005088

Ras guanyl-nucleotide exchange factor activity

FB:FBrf0112152
PMID:10471707[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005088

Ras guanyl-nucleotide exchange factor activity

FB:FBrf0123882

NAS: Non-traceable Author Statement

F

From FB

GO:0005089

Rho guanyl-nucleotide exchange factor activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000219

F

From FB

GO:0005515

protein binding

FB:FBrf0057899
PMID:8462098[2]

IPI: Inferred from Physical Interaction

FB:FBgn0004638

F

From FB

GO:0005543

phospholipid binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001849

F

From FB

GO:0005622

intracellular

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000219
InterPro:IPR000651
InterPro:IPR001895
InterPro:IPR008937

C

From FB

GO:0007015

actin filament organization

FB:FBrf0167741
PMID:14527345[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007265

Ras protein signal transduction

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07889

P

From FB

GO:0007399

nervous system development

FB:FBrf0123882

NAS: Non-traceable Author Statement

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0190195
PMID:16326394[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008293

torso signaling pathway

FB:FBrf0111327
PMID:10494038[5]

TAS: Traceable Author Statement

P

From FB

GO:0008360

regulation of cell shape

FB:FBrf0167741
PMID:14527345[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008595

anterior/posterior axis specification, embryo

FB:FBrf0111327
PMID:10494038[5]

TAS: Traceable Author Statement

P

From FB

GO:0035023

regulation of Rho protein signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000219

P

From FB

GO:0045500

sevenless signaling pathway

FB:FBrf0129916
PMID:10929403[6]

TAS: Traceable Author Statement

P

From FB

GO:0045749

negative regulation of S phase of mitotic cell cycle

FB:FBrf0187405
PMID:15809036[7]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Ashburner M et al. (1999) An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153: 179-219 PubMed GONUTS page
  2. Olivier JP et al. (1993) A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73: 179-91 PubMed GONUTS page
  3. 3.0 3.1 Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  4. Cabernard C & Affolter M (2005) Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell 9: 831-42 PubMed GONUTS page
  5. 5.0 5.1 Baek KH & Lee KY (1999) Signal transduction pathway for anterior-posterior development in Drosophila. J Biomed Sci 6: 314-9 PubMed GONUTS page
  6. Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
  7. Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox