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FB:Sh

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Sh ( synonyms: BcDNA:GH03046, CG12348, CG17860, CG7640, EKO, Eko, F-c, F-c transcription unit, SH, Sha, Shaker-downheld, Shw, V-I, minisleep, sh, shaker )
Protein Name(s) Shaker,
External Links
FB FBgn0003380

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001508

regulation of action potential

FB:FBrf0194198
PMID:16763031[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005249

voltage-gated potassium channel activity

FB:FBrf0081621
PMID:7542775[2]

NAS: Non-traceable Author Statement

F

From FB

GO:0005249

voltage-gated potassium channel activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q09470

F

From FB

GO:0005249

voltage-gated potassium channel activity

FB:FBrf0123455

NAS: Non-traceable Author Statement

F

From FB

GO:0005249

voltage-gated potassium channel activity

FB:FBrf0127201
PMID:10798390[3]

TAS: Traceable Author Statement

F

From FB

GO:0006813

potassium ion transport

FB:FBrf0123455

NAS: Non-traceable Author Statement

P

From FB

GO:0006813

potassium ion transport

FB:FBrf0127201
PMID:10798390[3]

TAS: Traceable Author Statement

P

From FB

GO:0006813

potassium ion transport

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR003091
InterPro:IPR003131
InterPro:IPR003968
InterPro:IPR003972

P

From FB

GO:0007611

learning or memory

FB:FBrf0141665
PMID:11715043[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0007619

courtship behavior

FB:FBrf0131304
PMID:11092827[5]

TAS: Traceable Author Statement

P

From FB

GO:0007619

courtship behavior

FB:FBrf0141665
PMID:11715043[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0007629

flight behavior

FB:FBrf0030192
PMID:17248760[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007637

proboscis extension reflex

FB:FBrf0187509
PMID:16121192[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008076

voltage-gated potassium channel complex

FB:FBrf0081621
PMID:7542775[2]

NAS: Non-traceable Author Statement

C

From FB

GO:0008076

voltage-gated potassium channel complex

FB:FBrf0127201
PMID:10798390[3]

TAS: Traceable Author Statement

C

From FB

GO:0008076

voltage-gated potassium channel complex

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR003091
InterPro:IPR003131
InterPro:IPR003968
InterPro:IPR003972

C

From FB

GO:0008345

larval locomotory behavior

FB:FBrf0194198
PMID:16763031[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009584

detection of visible light

FB:FBrf0190156
PMID:16168982[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016021

integral to membrane

FB:FBrf0123455

NAS: Non-traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0201150
PMID:17488813[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0022843

voltage-gated cation channel activity

FB:FBrf0159288
PMID:12606713[10]

IDA: Inferred from Direct Assay

F

From FB

GO:0022843

voltage-gated cation channel activity

FB:FBrf0214089
PMID:21059657[11]

IDA: Inferred from Direct Assay

F

From FB

GO:0030431

sleep

FB:FBrf0184967

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030431

sleep

FB:FBrf0206340
PMID:19038223[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045187

regulation of circadian sleep/wake cycle, sleep

FB:FBrf0195242
PMID:16753559[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048150

behavioral response to ether

FB:FBrf0141665
PMID:11715043[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0048675

axon extension

FB:FBrf0174851
PMID:14960616[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050909

sensory perception of taste

FB:FBrf0141665
PMID:11715043[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0055085

transmembrane transport

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

P

From FB

GO:0060025

regulation of synaptic activity

FB:FBrf0194198
PMID:16763031[1]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Ueda A & Wu CF (2006) Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations. J Neurosci 26: 6238-48 PubMed GONUTS page
  2. 2.0 2.1 Chouinard SW et al. (1995) A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A 92: 6763-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 Littleton JT & Ganetzky B (2000) Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26: 35-43 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
  5. Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page
  6. Homyk T & Sheppard DE (1977) Behavioral Mutants of DROSOPHILA MELANOGASTER. I. Isolation and Mapping of Mutations Which Decrease Flight Ability. Genetics 87: 95-104 PubMed GONUTS page
  7. Ishimoto H et al. (2005) G-protein gamma subunit 1 is required for sugar reception in Drosophila. EMBO J 24: 3259-65 PubMed GONUTS page
  8. Rodriguez Moncalvo VG & Campos AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev Biol 286: 549-58 PubMed GONUTS page
  9. Zhang L et al. (2007) Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain. Proc Natl Acad Sci U S A 104: 8263-8 PubMed GONUTS page
  10. Silverman WR et al. (2003) Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A 100: 2935-40 PubMed GONUTS page
  11. Li Y et al. (2011) Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents. J Biol Chem 286: 1389-99 PubMed GONUTS page
  12. Parisky KM et al. (2008) PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron 60: 672-82 PubMed GONUTS page
  13. Yuan Q et al. (2006) A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol 16: 1051-62 PubMed GONUTS page
  14. Zhong Y & Wu CF (2004) Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. J Neurosci 24: 1439-45 PubMed GONUTS page
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