GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:S6k
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | S6k ( synonyms: 10539, 7084, CG10539, DS6K, Dp70S6k, Dp70(s6k), Dp70s6k, S6 Kinase, S6 kinase, S6-kinase, S6K, S6K1, S6kinase, dS6 kinase, dS6K, dS6k, dp70(S6k), dp70s6k, dps6k, ds6k, fs(3)07084, l(3)07084, p70 S6 Kinase, p70 S6 kinase, p70 S6K, p70 ribosomal S6 kinase, p70 s6 kinase, p70/S6K, p70S6K, p70(S6 kinase), p70(S6K), p70(S6k), p70(S6kinase), p70s6K, ribosomal S6 protein kinase, ribosomal protein S6 kinase, s6k, s6k11 ) | |
| Protein Name(s) | RPS6-p70-protein kinase, | |
| External Links | ||
| FB | FBgn0015806 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004711 |
ribosomal protein S6 kinase activity |
FB:FBrf0090854 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004711 |
ribosomal protein S6 kinase activity |
FB:FBrf0090854 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004711 |
ribosomal protein S6 kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
protein_id:CAA07774 |
F |
From FB |
||
| GO:0004711 |
ribosomal protein S6 kinase activity |
FB:FBrf0132098 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
F |
From FB |
||
| GO:0005840 |
ribosome |
FB:FBrf0090854 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From FB |
||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006914 |
autophagy |
FB:FBrf0180117 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0208272 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007015 |
actin filament organization |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0007584 |
response to nutrient |
FB:FBrf0152245 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007584 |
response to nutrient |
FB:FBrf0156084 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0179269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008361 |
regulation of cell size |
FB:FBrf0157335 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030307 |
positive regulation of cell growth |
FB:FBrf0125443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030307 |
positive regulation of cell growth |
FB:FBrf0141377 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030307 |
positive regulation of cell growth |
FB:FBrf0156084 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030536 |
larval feeding behavior |
FB:FBrf0188283 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0033554 |
cellular response to stress |
FB:FBrf0209636 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0040007 |
growth |
FB:FBrf0187461 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
FB:FBrf0125443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
FB:FBrf0130003 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
FB:FBrf0136845 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0111434 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0130003 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0136845 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0159230 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0173088 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0209636 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0005198 |
P |
From FB |
||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045927 |
positive regulation of growth |
FB:FBrf0125443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046622 |
positive regulation of organ growth |
FB:FBrf0125443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046622 |
positive regulation of organ growth |
FB:FBrf0136845 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046622 |
positive regulation of organ growth |
FB:FBrf0173088 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0091142 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048786 |
presynaptic active zone |
FB:FBrf0216911 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0209531 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051124 |
synaptic growth at neuromuscular junction |
FB:FBrf0216911 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Watson KL et al. (1996) A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. Proc Natl Acad Sci U S A 93: 13694-8 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ Scott RC et al. (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7: 167-78 PubMed GONUTS page
- ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
- ↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
- ↑ Gao X et al. (2002) Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4: 699-704 PubMed GONUTS page
- ↑ 8.0 8.1 Oldham S & Hafen E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13: 79-85 PubMed GONUTS page
- ↑ Kapahi P et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-90 PubMed GONUTS page
- ↑ Gumienny TL & Padgett RW (2003) A small issue addressed. Bioessays 25: 305-8 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Weinkove D & Leevers SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr Opin Genet Dev 10: 75-80 PubMed GONUTS page
- ↑ Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ Wu Q et al. (2005) Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc Natl Acad Sci U S A 102: 13289-94 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Cully M et al. (2010) A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol 30: 481-95 PubMed GONUTS page
- ↑ Goberdhan DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132: 2365-75 PubMed GONUTS page
- ↑ 16.0 16.1 Oldham S et al. (2000) Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci 355: 945-52 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Potter CJ & Xu T (2001) Mechanisms of size control. Curr Opin Genet Dev 11: 279-86 PubMed GONUTS page
- ↑ Montagne J et al. (1999) Drosophila S6 kinase: a regulator of cell size. Science 285: 2126-9 PubMed GONUTS page
- ↑ Jacinto E & Hall MN (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4: 117-26 PubMed GONUTS page
- ↑ 20.0 20.1 Hafen E & Stocker H (2003) How are the sizes of cells, organs, and bodies controlled? PLoS Biol 1: E86 PubMed GONUTS page
- ↑ Perrimon N et al. (1996) Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics 144: 1681-92 PubMed GONUTS page
- ↑ 22.0 22.1 Cheng L et al. (2011) S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. J Cell Biol 194: 921-35 PubMed GONUTS page
- ↑ Koike-Kumagai M et al. (2009) The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J 28: 3879-92 PubMed GONUTS page
