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FB:Rpd3

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Rpd3 ( synonyms: CG7471, DHDAC1, DRpd3, DmHDAC1, E(var)3-64BC, HDAC, HDAC-1, HDAC1, Hdac1, Histone Deacetylase 1, Histone Deacetylase 1 (HDAC1), Histone Deacetylase-1, RPD3, Rpd3 histone deacetylase, Rpd3/HDAC, Su(var)3-26, Su(var)326, Su(var)328, Suppressor of variegation 326, dHDAC-1, dHDAC1, dRPD3, dRpd3, dmHDA401, drpd3, hdac1, histone deacetylase, histone deacetylase 1, l(3)04556, l(3)64Cc, reduced potassium dependency 3, rpd3, rpd(3) )
Protein Name(s) Rpd3,
External Links
FB FBgn0015805

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0190553
PMID:16391236[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0000785

chromatin

FB:FBrf0132059
PMID:11080159[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0003714

transcription corepressor activity

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

F

From FB

GO:0003714

transcription corepressor activity

FB:FBrf0190553
PMID:16391236[1]

IPI: Inferred from Physical Interaction

FB:FBgn0001297

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0090521
PMID:8955276[4]

ISS: Inferred from Sequence or Structural Similarity

HGNC:4852

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0090521
PMID:8955276[4]

ISS: Inferred from Sequence or Structural Similarity

SGD:S0005274

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P56517

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0120994

NAS: Non-traceable Author Statement

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0124387

NAS: Non-traceable Author Statement

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0135765
PMID:11281647[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0135832
PMID:11278256[6]

IDA: Inferred from Direct Assay

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0190553
PMID:16391236[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0004407

histone deacetylase activity

FB:FBrf0190812
PMID:16137856[7]

IDA: Inferred from Direct Assay

F

From FB

GO:0005515

protein binding

FB:FBrf0159213
PMID:12697833[8]

IPI: Inferred from Physical Interaction

FB:FBgn0003044

F

From FB

GO:0005515

protein binding

FB:FBrf0180259
PMID:15545624[9]

IPI: Inferred from Physical Interaction

FB:FBgn0033846

F

From FB

GO:0005515

protein binding

FB:FBrf0205731
PMID:18714374[10]

IPI: Inferred from Physical Interaction

FB:FBgn0036282

F

From FB

GO:0005634

nucleus

FB:FBrf0124387

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0132059
PMID:11080159[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0132295
PMID:11124122[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0151814
PMID:12408863[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0190553
PMID:16391236[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0190812
PMID:16137856[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0211659
PMID:18535655[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0005705

polytene chromosome interband

FB:FBrf0205145
PMID:18451879[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0006099

tricarboxylic acid cycle

FB:FBrf0202125
PMID:18042644[15]

IDA: Inferred from Direct Assay

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0132295
PMID:11124122[11]

IPI: Inferred from Physical Interaction

FB:FBgn0000588

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0132295
PMID:11124122[11]

IPI: Inferred from Physical Interaction

FB:FBgn0000629

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0137353
PMID:11493709[16]

IGI: Inferred from Genetic Interaction

FB:FBgn0003042

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0137353
PMID:11493709[16]

IPI: Inferred from Physical Interaction

FB:FBgn0003042

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0207924
PMID:18454196[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0025825

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0207924
PMID:18454196[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0190812
PMID:16137856[7]

IDA: Inferred from Direct Assay

P

From FB

GO:0007350

blastoderm segmentation

FB:FBrf0108900
PMID:10359792[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0190556
PMID:16547170[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0156049
PMID:12459580[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0167266
PMID:14616064[21]

TAS: Traceable Author Statement

P

From FB

GO:0016458

gene silencing

FB:FBrf0132295
PMID:11124122[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016575

histone deacetylation

FB:FBrf0124387

NAS: Non-traceable Author Statement

P

From FB

GO:0016575

histone deacetylation

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0016575

histone deacetylation

FB:FBrf0149111
PMID:12077326[22]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016575

histone deacetylation

FB:FBrf0211359
PMID:20660276[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016580

Sin3 complex

FB:FBrf0132059
PMID:11080159[2]

NAS: Non-traceable Author Statement

C

From FB

GO:0016581

NuRD complex

FB:FBrf0132059
PMID:11080159[2]

NAS: Non-traceable Author Statement

C

From FB

GO:0016581

NuRD complex

FB:FBrf0141519
PMID:11743021[24]

IPI: Inferred from Physical Interaction

FB:FBgn0262519

C

From FB

GO:0017053

transcriptional repressor complex

FB:FBrf0180423
PMID:15306652[25]

IPI: Inferred from Physical Interaction

FB:FBgn0260397

C

From FB

GO:0017053

transcriptional repressor complex

FB:FBrf0180423
PMID:15306652[25]

IPI: Inferred from Physical Interaction

FB:FBgn0261573

C

From FB

GO:0022008

neurogenesis

FB:FBrf0214431

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0022904

respiratory electron transport chain

FB:FBrf0202125
PMID:18042644[15]

IDA: Inferred from Direct Assay

P

From FB

GO:0031523

Myb complex

FB:FBrf0180259
PMID:15545624[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0151814
PMID:12408863[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0168050
PMID:14698615[26]

TAS: Traceable Author Statement

C

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0132059
PMID:11080159[2]

IEP: Inferred from Expression Pattern

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0048477

oogenesis

FB:FBrf0141797
PMID:11691830[3]

TAS: Traceable Author Statement

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190556
PMID:16547170[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050771

negative regulation of axonogenesis

FB:FBrf0211359
PMID:20660276[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0070822

Sin3-type complex

FB:FBrf0211588
PMID:20566628[27]

IDA: Inferred from Direct Assay

C

From FB

GO:0070983

dendrite guidance

FB:FBrf0211359
PMID:20660276[23]

IMP: Inferred from Mutant Phenotype

P

From FB


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 Miotto B et al. (2006) Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev 20: 101-12 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Pile LA & Wassarman DA (2000) Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression. EMBO J 19: 6131-40 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Courey AJ & Jia S (2001) Transcriptional repression: the long and the short of it. Genes Dev 15: 2786-96 PubMed GONUTS page
  4. ↑ 4.0 4.1 De Rubertis F et al. (1996) The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384: 589-91 PubMed GONUTS page
  5. ↑ Barlow AL et al. (2001) dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp Cell Res 265: 90-103 PubMed GONUTS page
  6. ↑ Huang X & Kadonaga JT (2001) Biochemical analysis of transcriptional repression by Drosophila histone deacetylase 1. J Biol Chem 276: 12497-500 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Cho Y et al. (2005) Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics 86: 606-17 PubMed GONUTS page
  8. ↑ Tie F et al. (2003) A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3. Mol Cell Biol 23: 3352-62 PubMed GONUTS page
  9. ↑ 9.0 9.1 Lewis PW et al. (2004) Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev 18: 2929-40 PubMed GONUTS page
  10. ↑ Thompson EC & Travers AA (2008) A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. PLoS One 3: e3008 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 Tie F et al. (2001) The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128: 275-86 PubMed GONUTS page
  12. ↑ 12.0 12.1 Czermin B et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185-96 PubMed GONUTS page
  13. ↑ Burgio G et al. (2008) Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. PLoS Genet 4: e1000089 PubMed GONUTS page
  14. ↑ Wang L et al. (2008) Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep 9: 555-62 PubMed GONUTS page
  15. ↑ 15.0 15.1 Chen J et al. (2008) Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Res 18: 123-36 PubMed GONUTS page
  16. ↑ 16.0 16.1 Chang YL et al. (2001) Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A 98: 9730-5 PubMed GONUTS page
  17. ↑ 17.0 17.1 Zhu CC et al. (2008) Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis. PLoS Genet 4: e1000009 PubMed GONUTS page
  18. ↑ Mannervik M & Levine M (1999) The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. Proc Natl Acad Sci U S A 96: 6797-801 PubMed GONUTS page
  19. ↑ 19.0 19.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
  20. ↑ Rogina B et al. (2002) Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 298: 1745 PubMed GONUTS page
  21. ↑ Helfand SL & Rogina B (2003) Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet 37: 329-48 PubMed GONUTS page
  22. ↑ Pile LA et al. (2002) The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Mol Cell Biol 22: 4965-76 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 Tea JS et al. (2010) Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero. J Neurosci 30: 9939-46 PubMed GONUTS page
  24. ↑ Murawsky CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep 2: 1089-94 PubMed GONUTS page
  25. ↑ 25.0 25.1 Dallman JE et al. (2004) A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J Neurosci 24: 7186-93 PubMed GONUTS page
  26. ↑ Lehmann M (2004) Anything else but GAGA: a nonhistone protein complex reshapes chromatin structure. Trends Genet 20: 15-22 PubMed GONUTS page
  27. ↑ Spain MM et al. (2010) Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem 285: 27457-67 PubMed GONUTS page
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