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FB:Rbf
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Rbf ( synonyms: CG7413, EG:34F3.3, FBF, RB, RBF, RBF1, Rb, Rb1, RbF, Rbf1, Retinoblastoma, dRBF, pRb, rb, rbf, rbf1, retinoblastoma, retinoblastoma factor, retinoblastoma family protein 1, retinoblastoma-family homolog, retinoblastoma-family protein ) | |
| Protein Name(s) | Retinoblastoma-family protein, | |
| External Links | ||
| FB | FBgn0015799 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000080 |
G1 phase of mitotic cell cycle |
FB:FBrf0106433 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0087034 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0106433 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0151952 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0180022 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0180259 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0038390 |
P |
From FB |
||
| GO:0000785 |
chromatin |
FB:FBrf0180022 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0141173 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0151282 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011715 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0141173 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0212298 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0007095 |
mitotic cell cycle G2/M transition DNA damage checkpoint |
FB:FBrf0212700 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261530 |
P |
From FB |
||
| GO:0007113 |
endomitotic cell cycle |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007307 |
eggshell chorion gene amplification |
FB:FBrf0161618 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007307 |
eggshell chorion gene amplification |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008134 |
transcription factor binding |
FB:FBrf0087034 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011763 |
F |
From FB |
||
| GO:0008134 |
transcription factor binding |
FB:FBrf0087034 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011766 |
F |
From FB |
||
| GO:0008134 |
transcription factor binding |
FB:FBrf0151952 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011763 |
F |
From FB |
||
| GO:0008134 |
transcription factor binding |
FB:FBrf0151952 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011766 |
F |
From FB |
||
| GO:0008134 |
transcription factor binding |
FB:FBrf0151952 |
IPI: Inferred from Physical Interaction |
FB:FBgn0024371 |
F |
From FB |
||
| GO:0008156 |
negative regulation of DNA replication |
FB:FBrf0134797 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0136845 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008630 |
DNA damage response, signal transduction resulting in induction of apoptosis |
FB:FBrf0205772 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010629 |
negative regulation of gene expression |
FB:FBrf0201281 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0031523 |
Myb complex |
FB:FBrf0180022 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0031523 |
Myb complex |
FB:FBrf0180259 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035189 |
Rb-E2F complex |
FB:FBrf0087034 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035189 |
Rb-E2F complex |
FB:FBrf0151952 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035189 |
Rb-E2F complex |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0042023 |
DNA endoreduplication |
FB:FBrf0179442 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0211700 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0207165 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
FB:FBrf0193071 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045749 |
negative regulation of S phase of mitotic cell cycle |
FB:FBrf0187405 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051101 |
regulation of DNA binding |
FB:FBrf0087034 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:9893 |
P |
From FB |
||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0106433 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Du W & Dyson N (1999) The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J 18: 916-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Du W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev 10: 1206-18 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Stevaux O et al. (2002) Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J 21: 4927-37 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Korenjak M et al. (2004) Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119: 181-93 PubMed GONUTS page
- ↑ 5.0 5.1 Lewis PW et al. (2004) Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev 18: 2929-40 PubMed GONUTS page
- ↑ Brumby AM et al. (2002) Drosophila cyclin E interacts with components of the Brahma complex. EMBO J 21: 3377-89 PubMed GONUTS page
- ↑ Acharya P et al. (2010) Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins. Mol Biol Cell 21: 3890-901 PubMed GONUTS page
- ↑ Kondo S & Perrimon N (2011) A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Sci Signal 4: rs1 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
- ↑ McNairn AJ & Gilbert DM (2003) Epigenomic replication: linking epigenetics to DNA replication. Bioessays 25: 647-56 PubMed GONUTS page
- ↑ Bosco G et al. (2001) DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol 3: 289-95 PubMed GONUTS page
- ↑ Potter CJ & Xu T (2001) Mechanisms of size control. Curr Opin Genet Dev 11: 279-86 PubMed GONUTS page
- ↑ Moon NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4: e1000153 PubMed GONUTS page
- ↑ Lu J et al. (2007) A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A 104: 9381-6 PubMed GONUTS page
- ↑ Shcherbata HR et al. (2004) The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development 131: 3169-81 PubMed GONUTS page
- ↑ Hsieh TC et al. (2010) Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet 6: e1001071 PubMed GONUTS page
- ↑ Tanaka-Matakatsu M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326: 347-56 PubMed GONUTS page
- ↑ Ullah Z et al. (2007) Retinoblastoma protein regulation by the COP9 signalosome. Mol Biol Cell 18: 1179-86 PubMed GONUTS page
- ↑ Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
