GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:Rac2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Rac2 ( synonyms: CG8556, D-Rac 2, D-Rac2, DRac2, DRacB, DmRAC2, Drac1b, Drac2, Rac, Rac GTPase, Rac-2, Rac1b, RacB, rac2 ) | |
| Protein Name(s) | Rac2, | |
| External Links | ||
| FB | FBgn0014011 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000902 |
cell morphogenesis |
FB:FBrf0212211 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0002009 |
morphogenesis of an epithelium |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0002433 |
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
FB:FBrf0200340 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0003924 |
GTPase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0004219 |
F |
From FB |
||
| GO:0003924 |
GTPase activity |
FB:FBrf0124067 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003924 |
GTPase activity |
FB:FBrf0128589 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005525 |
GTP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005622 |
intracellular |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0006909 |
phagocytosis |
FB:FBrf0200813 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0007390 |
germ-band shortening |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0187455 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007394 |
dorsal closure, elongation of leading edge cells |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007424 |
open tracheal system development |
FB:FBrf0155702 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0007426 |
tracheal outgrowth, open tracheal system |
FB:FBrf0155702 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0007435 |
salivary gland morphogenesis |
FB:FBrf0190152 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0007520 |
myoblast fusion |
FB:FBrf0151208 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008103 |
oocyte microtubule cytoskeleton polarization |
FB:FBrf0145749 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0145749 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008258 |
head involution |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030032 |
lamellipodium assembly |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0034334 |
adherens junction maintenance |
FB:FBrf0201358 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0035010 |
encapsulation of foreign target |
FB:FBrf0187605 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035099 |
hemocyte migration |
FB:FBrf0184064 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035099 |
hemocyte migration |
FB:FBrf0187835 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0042052 |
rhabdomere development |
FB:FBrf0145749 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042742 |
defense response to bacterium |
FB:FBrf0200813 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045451 |
pole plasm oskar mRNA localization |
FB:FBrf0145749 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046331 |
lateral inhibition |
FB:FBrf0214518 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050770 |
regulation of axonogenesis |
FB:FBrf0180582 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0041203 |
P |
From FB |
||
| GO:0051017 |
actin filament bundle assembly |
FB:FBrf0187401 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ D'Ambrosio MV & Vale RD (2010) A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Biol 191: 471-8 PubMed GONUTS page
- ↑ 2.0 2.1 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ Stuart LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol 170: 477-85 PubMed GONUTS page
- ↑ Newsome TP et al. (2000) Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101: 283-94 PubMed GONUTS page
- ↑ 5.0 5.1 Avet-Rochex A et al. (2007) Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells. Genes Cells 12: 1193-204 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Woolner S et al. (2005) The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closure. Dev Biol 282: 163-73 PubMed GONUTS page
- ↑ Denholm B et al. (2005) crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Development 132: 2389-400 PubMed GONUTS page
- ↑ 9.0 9.1 Chihara T et al. (2003) Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila. Development 130: 1419-28 PubMed GONUTS page
- ↑ Pirraglia C et al. (2006) Rac function in epithelial tube morphogenesis. Dev Biol 290: 435-46 PubMed GONUTS page
- ↑ Dworak HA & Sink H (2002) Myoblast fusion in Drosophila. Bioessays 24: 591-601 PubMed GONUTS page
- ↑ Bruinsma SP et al. (2007) Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye. Proc Natl Acad Sci U S A 104: 7098-103 PubMed GONUTS page
- ↑ Williams MJ et al. (2005) Drosophila melanogaster Rac2 is necessary for a proper cellular immune response. Genes Cells 10: 813-23 PubMed GONUTS page
- ↑ Stramer B et al. (2005) Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol 168: 567-73 PubMed GONUTS page
- ↑ Paladi M & Tepass U (2004) Function of Rho GTPases in embryonic blood cell migration in Drosophila. J Cell Sci 117: 6313-26 PubMed GONUTS page
- ↑ Ng J & Luo L (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44: 779-93 PubMed GONUTS page
