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FB:Pten
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Pten ( synonyms: CG5671, DPTEN, Drosophila phosphatase and tensin homologue deleted on chromosome 10, PI 3-phosphatase, PTEN, PTEN3, Phosphatase and tensin homologue, PtdIns(3,4,5)P3 phosphatase, dPTEN, dPten, dpten, phosphatase and tensin homolog, phosphatidylinositol (3,4,5)-trisphosphate phosphatase, pten ) | |
| Protein Name(s) | Pten, | |
| External Links | ||
| FB | FBgn0026379 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000287 |
magnesium ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0002164 |
larval development |
FB:FBrf0190035 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003779 |
actin binding |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004721 |
phosphoprotein phosphatase activity |
FB:FBrf0111917 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0004721 |
phosphoprotein phosphatase activity |
FB:FBrf0123020 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:9588 |
F |
From FB |
||
| GO:0004722 |
protein serine/threonine phosphatase activity |
FB:FBrf0195575 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0004725 |
protein tyrosine phosphatase activity |
FB:FBrf0141274 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:9588 |
F |
From FB |
||
| GO:0004726 |
non-membrane spanning protein tyrosine phosphatase activity |
FB:FBrf0111917 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0006470 |
protein dephosphorylation |
FB:FBrf0123020 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:9588 |
P |
From FB |
||
| GO:0006470 |
protein dephosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006470 |
protein dephosphorylation |
FB:FBrf0195575 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006629 |
lipid metabolic process |
FB:FBrf0192579 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006914 |
autophagy |
FB:FBrf0180118 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0111917 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0156191 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007010 |
cytoskeleton organization |
FB:FBrf0123020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007015 |
actin filament organization |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007155 |
cell adhesion |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007425 |
epithelial cell fate determination, open tracheal system |
FB:FBrf0141466 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007436 |
larval salivary gland morphogenesis |
FB:FBrf0187400 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007552 |
metamorphosis |
FB:FBrf0190035 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
FB:FBrf0111917 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0123020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0127089 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0111917 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015279 |
P |
From FB |
||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0111917 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0024248 |
P |
From FB |
||
| GO:0008286 |
insulin receptor signaling pathway |
FB:FBrf0141377 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008360 |
regulation of cell shape |
FB:FBrf0123020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008360 |
regulation of cell shape |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008361 |
regulation of cell size |
FB:FBrf0111917 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008361 |
regulation of cell size |
FB:FBrf0123020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008361 |
regulation of cell size |
FB:FBrf0156191 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0009887 |
organ morphogenesis |
FB:FBrf0127089 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009888 |
tissue development |
FB:FBrf0127089 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009987 |
cellular process |
FB:FBrf0127089 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016314 |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity |
FB:FBrf0123020 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015279 |
F |
From FB |
||
| GO:0016314 |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity |
FB:FBrf0123020 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:9588 |
F |
From FB |
||
| GO:0019915 |
lipid storage |
FB:FBrf0193043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030036 |
actin cytoskeleton organization |
FB:FBrf0183928 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030165 |
PDZ domain binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0030308 |
negative regulation of cell growth |
FB:FBrf0141377 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030336 |
negative regulation of cell migration |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0031647 |
regulation of protein stability |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0040014 |
regulation of multicellular organism growth |
FB:FBrf0156191 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0040014 |
regulation of multicellular organism growth |
FB:FBrf0190035 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0040015 |
negative regulation of multicellular organism growth |
FB:FBrf0151278 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042052 |
rhabdomere development |
FB:FBrf0190038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042594 |
response to starvation |
FB:FBrf0151278 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045786 |
negative regulation of cell cycle |
FB:FBrf0156191 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0125443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0136845 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045926 |
negative regulation of growth |
FB:FBrf0156084 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046620 |
regulation of organ growth |
FB:FBrf0156191 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0125443 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0130003 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0130065 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0136845 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
FB:FBrf0130003 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
FB:FBrf0136845 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
FB:FBrf0156191 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046855 |
inositol phosphate dephosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0046856 |
phosphatidylinositol dephosphorylation |
FB:FBrf0130003 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046856 |
phosphatidylinositol dephosphorylation |
FB:FBrf0156084 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046856 |
phosphatidylinositol dephosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0050773 |
regulation of dendrite development |
FB:FBrf0208858 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051800 |
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0051895 |
negative regulation of focal adhesion assembly |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mirth C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr Biol 15: 1796-807 PubMed GONUTS page
- ↑ Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Huang H et al. (1999) PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126: 5365-72 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Goberdhan DC et al. (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev 13: 3244-58 PubMed GONUTS page
- ↑ 5.0 5.1 Gao T et al. (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13-24 PubMed GONUTS page
- ↑ 6.0 6.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ Gutierrez E et al. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445: 275-80 PubMed GONUTS page
- ↑ Rusten TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell 7: 179-92 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Claeys I et al. (2002) Insulin-related peptides and their conserved signal transduction pathway. Peptides 23: 807-16 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
- ↑ Jin J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev Cell 1: 817-27 PubMed GONUTS page
- ↑ Takeo S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev Biol 284: 204-18 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Gao X et al. (2000) Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev Biol 221: 404-18 PubMed GONUTS page
- ↑ 14.0 14.1 Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ Vereshchagina N & Wilson C (2006) Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133: 4731-5 PubMed GONUTS page
- ↑ von Stein W et al. (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132: 1675-86 PubMed GONUTS page
- ↑ 17.0 17.1 Oldham S et al. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development 129: 4103-9 PubMed GONUTS page
- ↑ Pinal N et al. (2006) Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr Biol 16: 140-9 PubMed GONUTS page
- ↑ 19.0 19.1 Weinkove D & Leevers SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr Opin Genet Dev 10: 75-80 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Potter CJ & Xu T (2001) Mechanisms of size control. Curr Opin Genet Dev 11: 279-86 PubMed GONUTS page
- ↑ 21.0 21.1 Oldham S & Hafen E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13: 79-85 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 Oldham S et al. (2000) Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci 355: 945-52 PubMed GONUTS page
- ↑ Scanga SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19: 3971-7 PubMed GONUTS page
- ↑ Parrish JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63: 788-802 PubMed GONUTS page
