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FB:Pink1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Pink1 ( synonyms: BEST:GH23468, CG4523, PINK, PINK1, PTEN induced putative kinase 1, PTEN-Induced Kinase 1, dPINK1, dPink1, pink1 ) | |
| Protein Name(s) | PTEN-induced putative kinase 1, | |
| External Links | ||
| FB | FBgn0029891 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000266 |
mitochondrial fission |
FB:FBrf0202793 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026479 |
P |
From FB |
||
| GO:0000266 |
mitochondrial fission |
FB:FBrf0202793 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0029870 |
P |
From FB |
||
| GO:0000266 |
mitochondrial fission |
FB:FBrf0202793 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261276 |
P |
From FB |
||
| GO:0000266 |
mitochondrial fission |
FB:FBrf0205047 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026479 |
P |
From FB |
||
| GO:0000266 |
mitochondrial fission |
FB:FBrf0205047 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261276 |
P |
From FB |
||
| GO:0004672 |
protein kinase activity |
FB:FBrf0151620 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0212500 |
IPI: Inferred from Physical Interaction |
FB:FBgn0023517 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0006979 |
response to oxidative stress |
FB:FBrf0192173 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0191922 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0193434 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0193630 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0040491 |
P |
From FB |
||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0193630 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0202793 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0205047 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007005 |
mitochondrion organization |
FB:FBrf0206104 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010821 |
regulation of mitochondrion organization |
FB:FBrf0208627 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016006 |
Nebenkern |
FB:FBrf0193434 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030382 |
sperm mitochondrion organization |
FB:FBrf0193434 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030382 |
sperm mitochondrion organization |
FB:FBrf0193630 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030382 |
sperm mitochondrion organization |
FB:FBrf0206104 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043069 |
negative regulation of programmed cell death |
FB:FBrf0192173 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
FB:FBrf0191922 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0192173 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Poole AC et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A 105: 1638-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Yang Y et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 105: 7070-5 PubMed GONUTS page
- ↑ Imai Y et al. (2010) The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet 6: e1001229 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Wang D et al. (2006) Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A 103: 13520-5 PubMed GONUTS page
- ↑ 5.0 5.1 Yang Y et al. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A 103: 10793-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Clark IE et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441: 1162-6 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Park J et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441: 1157-61 PubMed GONUTS page
- ↑ 8.0 8.1 Deng H et al. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105: 14503-8 PubMed GONUTS page
- ↑ Lutz AK et al. (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 284: 22938-51 PubMed GONUTS page
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