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FB:Pc

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Pc ( synonyms: CG32443, CG7618, DmPc, PC, Pc-G, PcG, dPC )
Protein Name(s) Polycomb,
External Links
FB FBgn0003042

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000785

chromatin

FB:FBrf0190604
PMID:16272126[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0000785

chromatin

FB:FBrf0204496

IDA: Inferred from Direct Assay

C

From FB

GO:0003682

chromatin binding

FB:FBrf0191372
PMID:16613483[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9HC52

C

From FB

GO:0005634

nucleus

FB:FBrf0173118
PMID:14630938[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0189910
PMID:16530043[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005725

intercalary heterochromatin

FB:FBrf0173280
PMID:14579245[5]

NAS: Non-traceable Author Statement

C

From FB

GO:0005730

nucleolus

FB:FBrf0190604
PMID:16272126[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005730

nucleolus

FB:FBrf0204496

IDA: Inferred from Direct Assay

C

From FB

GO:0006342

chromatin silencing

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9HC52

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0123875

NAS: Non-traceable Author Statement

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0201535
PMID:17519021[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007385

specification of segmental identity, abdomen

FB:FBrf0187379
PMID:15893978[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016322

neuron remodeling

FB:FBrf0190330
PMID:16495309[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016458

gene silencing

FB:FBrf0135809
PMID:11333237[9]

IGI: Inferred from Genetic Interaction

FB:FBgn0004861

P

From FB

GO:0016458

gene silencing

FB:FBrf0135809
PMID:11333237[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0022008

neurogenesis

FB:FBrf0202325
PMID:17287254[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035064

methylated histone residue binding

FB:FBrf0151814
PMID:12408863[11]

IDA: Inferred from Direct Assay

F

From FB

GO:0035064

methylated histone residue binding

FB:FBrf0173275

TAS: Traceable Author Statement

F

From FB

GO:0035102

PRC1 complex

FB:FBrf0131031
PMID:10904264[12]

TAS: Traceable Author Statement

C

From FB

GO:0035102

PRC1 complex

FB:FBrf0168050
PMID:14698615[13]

TAS: Traceable Author Statement

C

From FB

GO:0035102

PRC1 complex

FB:FBrf0173118
PMID:14630938[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0035102

PRC1 complex

FB:FBrf0183709
PMID:15337121[14]

TAS: Traceable Author Statement

C

From FB

GO:0035186

syncytial blastoderm mitotic cell cycle

FB:FBrf0190149
PMID:16388795[15]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Chen X et al. (2005) Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science 310: 869-72 PubMed GONUTS page
  2. Nègre N et al. (2006) Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol 4: e170 PubMed GONUTS page
  3. 3.0 3.1 Mulholland NM et al. (2003) Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Genes Dev 17: 2741-6 PubMed GONUTS page
  4. Grimaud C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124: 957-71 PubMed GONUTS page
  5. Zhimulev IF & Belyaeva ES (2003) Intercalary heterochromatin and genetic silencing. Bioessays 25: 1040-51 PubMed GONUTS page
  6. Goodliffe JM et al. (2007) Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC Mol Biol 8: 40 PubMed GONUTS page
  7. Chen EH et al. (2005) Allocation and specification of the genital disc precursor cells in Drosophila. Dev Biol 281: 270-85 PubMed GONUTS page
  8. Wang J et al. (2006) Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development 133: 1231-40 PubMed GONUTS page
  9. 9.0 9.1 Roseman RR et al. (2001) Long-range repression by multiple polycomb group (PcG) proteins targeted by fusion to a defined DNA-binding domain in Drosophila. Genetics 158: 291-307 PubMed GONUTS page
  10. Bello B et al. (2007) Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila. Development 134: 1091-9 PubMed GONUTS page
  11. Czermin B et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185-96 PubMed GONUTS page
  12. Ahringer J (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet 16: 351-6 PubMed GONUTS page
  13. Lehmann M (2004) Anything else but GAGA: a nonhistone protein complex reshapes chromatin structure. Trends Genet 20: 15-22 PubMed GONUTS page
  14. Levine SS et al. (2004) Division of labor in polycomb group repression. Trends Biochem Sci 29: 478-85 PubMed GONUTS page
  15. O'Dor E et al. (2006) Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. Dev Biol 290: 312-22 PubMed GONUTS page
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