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FB:Parp

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Parp ( synonyms: BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, LD21673.3prime, PARP, PARP-1, PARP1, Poly(ADP ribose) polymerase 1, Poly(ADP)-Ribose Polymerase, Poly(ADP-)Ribose Polymerase, Poly(ADP-ribose) Polymerase 1, Poly(ADP-ribose) polymerase, dPARP, parp, poly(ADP-ribose) polymerase )
Protein Name(s) Poly-(ADP-ribose) polymerase,
External Links
FB FBgn0010247

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001510
InterPro:IPR008288

F

From FB

GO:0003950

NAD+ ADP-ribosyltransferase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

EMBL:M18112

F

From FB

GO:0003950

NAD+ ADP-ribosyltransferase activity

FB:FBrf0211658
PMID:17827147[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0141196

NAS: Non-traceable Author Statement

C

From FB

GO:0005694

chromosome

FB:FBrf0190776
PMID:16219773[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0155525
PMID:12543974[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0179901

TAS: Traceable Author Statement

C

From FB

GO:0005703

polytene chromosome puff

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

C

From FB

GO:0005703

polytene chromosome puff

FB:FBrf0155525
PMID:12543974[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005719

nuclear euchromatin

FB:FBrf0155525
PMID:12543974[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005730

nucleolus

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

C

From FB

GO:0005730

nucleolus

FB:FBrf0179901

TAS: Traceable Author Statement

C

From FB

GO:0005730

nucleolus

FB:FBrf0190776
PMID:16219773[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0006471

protein ADP-ribosylation

FB:FBrf0141196

NAS: Non-traceable Author Statement

P

From FB

GO:0006471

protein ADP-ribosylation

FB:FBrf0151719
PMID:12183365[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006471

protein ADP-ribosylation

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0006963

positive regulation of antibacterial peptide biosynthetic process

FB:FBrf0155525
PMID:12543974[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007000

nucleolus organization

FB:FBrf0151719
PMID:12183365[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007000

nucleolus organization

FB:FBrf0190776
PMID:16219773[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007552

metamorphosis

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001510
InterPro:IPR008288

F

From FB

GO:0009303

rRNA transcription

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0035079

polytene chromosome puffing

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0035079

polytene chromosome puffing

FB:FBrf0179901

TAS: Traceable Author Statement

P

From FB

GO:0035080

heat shock-mediated polytene chromosome puffing

FB:FBrf0155525
PMID:12543974[4]

IEP: Inferred from Expression Pattern

P

From FB

GO:0035080

heat shock-mediated polytene chromosome puffing

FB:FBrf0155525
PMID:12543974[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042393

histone binding

FB:FBrf0211658
PMID:17827147[1]

IPI: Inferred from Physical Interaction

FB:FBgn0001196

F

From FB

GO:0042393

histone binding

FB:FBrf0211658
PMID:17827147[1]

IPI: Inferred from Physical Interaction

FB:FBgn0001198

F

From FB

GO:0042393

histone binding

FB:FBrf0211658
PMID:17827147[1]

IPI: Inferred from Physical Interaction

FB:FBgn0001199

F

From FB

GO:0042393

histone binding

FB:FBrf0211658
PMID:17827147[1]

IPI: Inferred from Physical Interaction

FB:FBgn0001200

F

From FB

GO:0043484

regulation of RNA splicing

FB:FBrf0208236
PMID:19346337[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045087

innate immune response

FB:FBrf0155525
PMID:12543974[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051276

chromosome organization

FB:FBrf0155514
PMID:12543962[3]

TAS: Traceable Author Statement

P

From FB

GO:0051287

NAD binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR008288

F

From FB

GO:0051457

maintenance of protein location in nucleus

FB:FBrf0190776
PMID:16219773[2]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Pinnola A et al. (2007) Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J Biol Chem 282: 32511-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Tulin A et al. (2006) Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics 172: 363-71 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Pirrotta V (2003) Transcription. Puffing with PARP. Science 299: 528-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Tulin A & Spradling A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299: 560-2 PubMed GONUTS page
  5. 5.0 5.1 Tulin A et al. (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev 16: 2108-19 PubMed GONUTS page
  6. Ji Y & Tulin AV (2009) Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res 37: 3501-13 PubMed GONUTS page
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