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FB:Pak
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Pak ( synonyms: CG10295, D-Pak, DPAK, DPak, DmPAK1, Dpak, Dpak1, P21-activated kinase, PAK, PAK kinase, PAK1, PAK2, PaK, Pak kinase, Pak1, Pak1 kinase, dPAK, dPAK1, dPak, dpak, dpak1, p-21 activated kinase, p21 activated kinase, p21- activated kinase, p21-activated kinase, p21-activated serine/threonine kinase, p21-associated kinase, p65(PAK), pak, pak1 ) | |
| Protein Name(s) | PAK-kinase, | |
| External Links | ||
| FB | FBgn0014001 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0087303 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0107439 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0108798 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005856 |
cytoskeleton |
FB:FBrf0180111 |
IMP: Inferred from Mutant Phenotype |
C |
From FB |
|||
| GO:0005925 |
focal adhesion |
FB:FBrf0087303 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0007155 |
cell adhesion |
FB:FBrf0087303 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0110443 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0180111 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0108798 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0108798 |
IPI: Inferred from Physical Interaction |
FB:FBgn0010583 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0128589 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0128634 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0033159 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0136755 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0179899 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0210319 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008360 |
regulation of cell shape |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016328 |
lateral plasma membrane |
FB:FBrf0210918 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016601 |
Rac protein signal transduction |
FB:FBrf0155635 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0019991 |
septate junction assembly |
FB:FBrf0210918 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050770 |
regulation of axonogenesis |
FB:FBrf0180582 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0041203 |
P |
From FB |
||
| GO:0050803 |
regulation of synapse structure and activity |
FB:FBrf0180421 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Harden N et al. (1996) A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol Cell Biol 16: 1896-908 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Hing H et al. (1999) Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97: 853-63 PubMed GONUTS page
- ↑ 3.0 3.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 4.0 4.1 Conder R et al. (2004) dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev Biol 276: 378-90 PubMed GONUTS page
- ↑ 5.0 5.1 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
- ↑ Newsome TP et al. (2000) Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101: 283-94 PubMed GONUTS page
- ↑ Schmucker D et al. (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101: 671-84 PubMed GONUTS page
- ↑ Bateman J & Van Vactor D (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J Cell Sci 114: 1973-80 PubMed GONUTS page
- ↑ Hallem EA & Carlson JR (2004) The odor coding system of Drosophila. Trends Genet 20: 453-9 PubMed GONUTS page
- ↑ Berger J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet 4: e1000085 PubMed GONUTS page
- ↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
- ↑ 12.0 12.1 Bahri S et al. (2010) The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. Development 137: 2023-32 PubMed GONUTS page
- ↑ Patel BN & Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol 14: 221-9 PubMed GONUTS page
- ↑ Ng J & Luo L (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44: 779-93 PubMed GONUTS page
- ↑ Albin SD & Davis GW (2004) Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. J Neurosci 24: 6871-9 PubMed GONUTS page
