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FB:PGRP-SA
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | PGRP-SA ( synonyms: BcDNA:AT30827, CG11709, Dm PGRP-SA, Peptidoglycan recognition protein-SA, Peptidoglycan-recognition protein-SA precursor, Protein semmelweis, SA, SEMMELWEIS, peptidoglycan recognition protein SA, seml, semmelweis, semmelweiss ) | |
| Protein Name(s) | Peptidoglycan recognition protein SA, | |
| External Links | ||
| FB | FBgn0030310 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
FB:FBrf0194406 |
IPI: Inferred from Physical Interaction |
FB:FBgn0040323 |
F |
From FB |
||
| GO:0005576 |
extracellular region |
FB:FBrf0131424 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0141671 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0179457 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005887 |
integral to plasma membrane |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0131424 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0167392 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006965 |
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria |
FB:FBrf0141671 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006965 |
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria |
FB:FBrf0174342 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006965 |
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria |
FB:FBrf0201848 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0179457 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008329 |
pattern recognition receptor activity |
FB:FBrf0167392 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0008592 |
regulation of Toll signaling pathway |
FB:FBrf0167392 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008745 |
N-acetylmuramoyl-L-alanine amidase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0009253 |
peptidoglycan catabolic process |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0016019 |
peptidoglycan receptor activity |
FB:FBrf0130986 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0016019 |
peptidoglycan receptor activity |
FB:FBrf0131424 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0016019 |
peptidoglycan receptor activity |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0016019 |
peptidoglycan receptor activity |
FB:FBrf0179043 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0016019 |
peptidoglycan receptor activity |
FB:FBrf0179457 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0016045 |
detection of bacterium |
FB:FBrf0130986 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0032494 |
response to peptidoglycan |
FB:FBrf0194406 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0032500 |
muramyl dipeptide binding |
FB:FBrf0194406 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0042834 |
peptidoglycan binding |
FB:FBrf0131424 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0042834 |
peptidoglycan binding |
FB:FBrf0179043 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0042834 |
peptidoglycan binding |
FB:FBrf0179457 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0042834 |
peptidoglycan binding |
FB:FBrf0188267 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0042834 |
peptidoglycan binding |
FB:FBrf0201848 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0179457 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0188361 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0168033 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0040323 |
P |
From FB |
||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0174342 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wang L et al. (2006) Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J 25: 5005-14 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Werner T et al. (2000) A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A 97: 13772-7 PubMed GONUTS page
- ↑ 3.0 3.1 Michel T et al. (2001) Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414: 756-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Steiner H (2004) Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunol Rev 198: 83-96 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Janssens S & Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16: 637-46 PubMed GONUTS page
- ↑ 6.0 6.1 Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page
- ↑ 7.0 7.1 Park JW et al. (2007) Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Proc Natl Acad Sci U S A 104: 6602-7 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
- ↑ Mellroth P et al. (2005) Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro. Proc Natl Acad Sci U S A 102: 6455-60 PubMed GONUTS page
- ↑ Kwiatkowski DP (2005) The complexity of genetic variation in a simple immune system. Trends Genet 21: 197-9 PubMed GONUTS page
- ↑ Gobert V et al. (2003) Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science 302: 2126-30 PubMed GONUTS page
