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FB:Nc
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Nc ( synonyms: CG8090, CG8091, Caspase-9-like, DRONC, Dronc, Dronc/Casp9, Drosophila Nedd2-like caspase, Nc\Dronc, Nedd 2-like caspase, anon-EST:GreesD6, anon-EST:GressD6, anon-WO0118547.313, caspase-9, dronc ) | |
| Protein Name(s) | Nedd2-like caspase, | |
| External Links | ||
| FB | FBgn0026404 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001700 |
embryonic development via the syncytial blastoderm |
FB:FBrf0134503 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0001700 |
embryonic development via the syncytial blastoderm |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0004175 |
endopeptidase activity |
FB:FBrf0190910 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0108172 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0108172 |
ISS: Inferred from Sequence or Structural Similarity |
WP:CE29088 |
F |
From FB |
||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0111320 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0117086 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0125395 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0132215 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0156100 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
FB:FBrf0190361 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0108172 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006508 |
proteolysis |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001309 |
P |
From FB |
||
| GO:0006915 |
apoptotic process |
FB:FBrf0108172 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0108172 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0125395 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0260635 |
P |
From FB |
||
| GO:0006915 |
apoptotic process |
FB:FBrf0125395 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0125395 |
IPI: Inferred from Physical Interaction |
FB:FBgn0260635 |
P |
From FB |
||
| GO:0006915 |
apoptotic process |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0167429 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0173268 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0180130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0187492 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0202061 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0167989 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0190354 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007417 |
central nervous system development |
FB:FBrf0180130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190361 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007516 |
hemocyte development |
FB:FBrf0180130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007552 |
metamorphosis |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008258 |
head involution |
FB:FBrf0180130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0189997 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010623 |
developmental programmed cell death |
FB:FBrf0193775 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010941 |
regulation of cell death |
FB:FBrf0211843 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0012501 |
programmed cell death |
FB:FBrf0212368 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0016322 |
neuron remodeling |
FB:FBrf0210748 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016540 |
protein autoprocessing |
FB:FBrf0190910 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0031638 |
zymogen activation |
FB:FBrf0190910 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0031638 |
zymogen activation |
FB:FBrf0190910 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035070 |
salivary gland histolysis |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035071 |
salivary gland cell autophagic cell death |
FB:FBrf0158811 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0035081 |
induction of programmed cell death by hormones |
FB:FBrf0133206 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042803 |
protein homodimerization activity |
FB:FBrf0190910 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0046668 |
regulation of retinal cell programmed cell death |
FB:FBrf0156100 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046672 |
positive regulation of compound eye retinal cell programmed cell death |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048102 |
autophagic cell death |
FB:FBrf0158811 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0180130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0192062 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
NOT |
GO:0005739 |
mitochondrion |
FB:FBrf0108172 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Kumar S & Doumanis J (2000) The fly caspases. Cell Death Differ 7: 1039-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Yan N et al. (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem 281: 8667-74 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Dorstyn L et al. (1999) DRONC, an ecdysone-inducible Drosophila caspase. Proc Natl Acad Sci U S A 96: 4307-12 PubMed GONUTS page
- ↑ Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Meier P et al. (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J 19: 598-611 PubMed GONUTS page
- ↑ Tittel JN & Steller H (2000) A comparison of programmed cell death between species. Genome Biol 1: REVIEWS0003 PubMed GONUTS page
- ↑ 8.0 8.1 Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page
- ↑ 9.0 9.1 Kanuka H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J 24: 3793-806 PubMed GONUTS page
- ↑ Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page
- ↑ Lawen A (2003) Apoptosis-an introduction. Bioessays 25: 888-96 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 Chew SK et al. (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell 7: 897-907 PubMed GONUTS page
- ↑ Xu D et al. (2005) The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132: 2125-34 PubMed GONUTS page
- ↑ Akdemir F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26: 5184-93 PubMed GONUTS page
- ↑ Huh JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol 2: E15 PubMed GONUTS page
- ↑ Arama E et al. (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J 25: 232-43 PubMed GONUTS page
- ↑ Bauer JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15: 2063-8 PubMed GONUTS page
- ↑ Kondo S et al. (2006) DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol 26: 7258-68 PubMed GONUTS page
- ↑ Yang CS et al. (2010) Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J 29: 3196-207 PubMed GONUTS page
- ↑ Lee G et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J Comp Neurol 519: 34-48 PubMed GONUTS page
- ↑ Schoenmann Z et al. (2010) Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J Neurosci 30: 6375-86 PubMed GONUTS page
- ↑ 22.0 22.1 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
- ↑ 23.0 23.1 Gorski SM et al. (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol 13: 358-63 PubMed GONUTS page
- ↑ Buszczak M & Segraves WA (2000) Insect metamorphosis: out with the old, in with the new. Curr Biol 10: R830-3 PubMed GONUTS page
- ↑ Williams DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 9: 1234-6 PubMed GONUTS page
