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FB:N

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) N ( synonyms: 1.1, 16-178, 16-55, Abruptex, Ax, CG3936, CT13012, Chopped, Chp, Co, Confluens, EG:140G11.1, EG:163A10.2, NECD, NICD, NOTCH, Notc, anon-EST:Liang-1.12, clone 1.12, co, dNotch, fa, facet, l(1)3Cb, l(1)Ax, l(1)N, n(fah), nd, notch, notchoid, shd, spl, split, strawberry, swb )
Protein Name(s) Notch,
External Links
FB FBgn0004647

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

P

From FB

GO:0001708

cell fate specification

FB:FBrf0103246
PMID:9642168[2]

TAS: Traceable Author Statement

P

From FB

GO:0001708

cell fate specification

FB:FBrf0141762
PMID:11735386[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0167947
PMID:14702038[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0187397
PMID:16039641[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0202887
PMID:18166433[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003682

chromatin binding

FB:FBrf0194300
PMID:16763555[7]

IDA: Inferred from Direct Assay

F

From FB

GO:0004872

receptor activity

FB:FBrf0123421

NAS: Non-traceable Author Statement

F

From FB

GO:0004872

receptor activity

FB:FBrf0137174
PMID:11494317[8]

TAS: Traceable Author Statement

F

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

F

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0144824
PMID:11880339[9]

NAS: Non-traceable Author Statement

F

From FB

GO:0005509

calcium ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001881
InterPro:IPR018097

F

From FB

GO:0005515

protein binding

FB:FBrf0144817
PMID:11861487[10]

IPI: Inferred from Physical Interaction

FB:FBgn0000524

F

From FB

GO:0005515

protein binding

FB:FBrf0183817
PMID:15620649[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VVI3

F

From FB

GO:0005515

protein binding

FB:FBrf0183818
PMID:15620650[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Y0H4

F

From FB

GO:0005515

protein binding

FB:FBrf0192755
PMID:17212657[13]

IPI: Inferred from Physical Interaction

FB:FBgn0003391

F

From FB

GO:0005515

protein binding

FB:FBrf0200934
PMID:17535912[14]

IPI: Inferred from Physical Interaction

FB:FBgn0004837

F

From FB

GO:0005515

protein binding

FB:FBrf0210603
PMID:20203305[15]

IPI: Inferred from Physical Interaction

FB:FBgn0000463

F

From FB

GO:0005515

protein binding

FB:FBrf0210603
PMID:20203305[15]

IPI: Inferred from Physical Interaction

FB:FBgn0004197

F

From FB

GO:0005515

protein binding

FB:FBrf0210603
PMID:20203305[15]

IPI: Inferred from Physical Interaction

FB:FBgn0051665

F

From FB

GO:0005622

intracellular

FB:FBrf0076038
PMID:7954795[16]

IDA: Inferred from Direct Assay

C

From FB

GO:0005622

intracellular

FB:FBrf0123421

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0151280
PMID:12147138[17]

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0155963
PMID:12556495[18]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0160750
PMID:12879448[19]

TAS: Traceable Author Statement

C

From FB

GO:0005886

plasma membrane

FB:FBrf0076038
PMID:7954795[16]

IDA: Inferred from Direct Assay

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0123421

NAS: Non-traceable Author Statement

C

From FB

GO:0005912

adherens junction

FB:FBrf0192755
PMID:17212657[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0007015

actin filament organization

FB:FBrf0187471
PMID:16049109[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007155

cell adhesion

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

P

From FB

GO:0007157

heterophilic cell-cell adhesion

FB:FBrf0184061
PMID:15611340[21]

IDA: Inferred from Direct Assay

P

From FB

GO:0007157

heterophilic cell-cell adhesion

FB:FBrf0184061
PMID:15611340[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0105495

NAS: Non-traceable Author Statement

P

From FB

GO:0007293

germarium-derived egg chamber formation

FB:FBrf0137222
PMID:11493544[22]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007293

germarium-derived egg chamber formation

FB:FBrf0139618
PMID:11591336[23]

TAS: Traceable Author Statement

P

From FB

GO:0007297

ovarian follicle cell migration

FB:FBrf0190110
PMID:16223477[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0187480
PMID:16014514[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0191839
PMID:17010965[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007314

oocyte anterior/posterior axis specification

FB:FBrf0139618
PMID:11591336[23]

TAS: Traceable Author Statement

P

From FB

GO:0007314

oocyte anterior/posterior axis specification

FB:FBrf0160750
PMID:12879448[19]

TAS: Traceable Author Statement

P

From FB

GO:0007346

regulation of mitotic cell cycle

FB:FBrf0167269
PMID:14616073[27]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0151280
PMID:12147138[17]

TAS: Traceable Author Statement

P

From FB

GO:0007398

ectoderm development

FB:FBrf0053362
PMID:1913825[28]

TAS: Traceable Author Statement

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0209288
PMID:19782677[29]

IDA: Inferred from Direct Assay

P

From FB

GO:0007403

glial cell fate determination

FB:FBrf0135724
PMID:11262244[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007403

glial cell fate determination

FB:FBrf0136040
PMID:11262238[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007403

glial cell fate determination

FB:FBrf0146991
PMID:11973271[32]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0159717
PMID:12781136[33]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007419

ventral cord development

FB:FBrf0158840
PMID:12593977[34]

NAS: Non-traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0131381
PMID:11102367[35]

TAS: Traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0136040
PMID:11262238[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007423

sensory organ development

FB:FBrf0141440
PMID:11719214[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0125237
PMID:10684581[37]

TAS: Traceable Author Statement

P

From FB

GO:0007440

foregut morphogenesis

FB:FBrf0174516
PMID:14975725[38]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007446

imaginal disc growth

FB:FBrf0125443
PMID:10679387[39]

TAS: Traceable Author Statement

P

From FB

GO:0007447

imaginal disc pattern formation

FB:FBrf0125443
PMID:10679387[39]

TAS: Traceable Author Statement

P

From FB

GO:0007450

dorsal/ventral pattern formation, imaginal disc

FB:FBrf0145168
PMID:11875444[40]

TAS: Traceable Author Statement

P

From FB

GO:0007451

dorsal/ventral lineage restriction, imaginal disc

FB:FBrf0141064
PMID:11253649[41]

TAS: Traceable Author Statement

P

From FB

GO:0007460

R8 cell fate commitment

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

P

From FB

GO:0007464

R3/R4 cell fate commitment

FB:FBrf0156094
PMID:12414186[42]

NAS: Non-traceable Author Statement

P

From FB

GO:0007473

wing disc proximal/distal pattern formation

FB:FBrf0158727
PMID:12717815[43]

TAS: Traceable Author Statement

P

From FB

GO:0007474

imaginal disc-derived wing vein specification

FB:FBrf0199183
PMID:15452147[44]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0145168
PMID:11875444[40]

NAS: Non-traceable Author Statement

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0160464
PMID:12782270[45]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0167472
PMID:14536058[46]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007478

leg disc morphogenesis

FB:FBrf0123139
PMID:10625531[47]

TAS: Traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0053362
PMID:1913825[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007519

skeletal muscle tissue development

FB:FBrf0128410
PMID:10859168[48]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007521

muscle cell fate determination

FB:FBrf0160590
PMID:12756185[49]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007616

long-term memory

FB:FBrf0179219
PMID:15220476[50]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007616

long-term memory

FB:FBrf0179893

TAS: Traceable Author Statement

P

From FB

GO:0007616

long-term memory

FB:FBrf0206600
PMID:19104051[51]

IGI: Inferred from Genetic Interaction

FB:FBgn0017590

P

From FB

GO:0008045

motor axon guidance

FB:FBrf0212819
PMID:21246649[52]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008284

positive regulation of cell proliferation

FB:FBrf0187397
PMID:16039641[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008347

glial cell migration

FB:FBrf0191976
PMID:17157832[53]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0158840
PMID:12593977[34]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0174511
PMID:15018932[54]

TAS: Traceable Author Statement

P

From FB

GO:0008407

chaeta morphogenesis

FB:FBrf0190182
PMID:16168983[55]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008587

imaginal disc-derived wing margin morphogenesis

FB:FBrf0162239
PMID:12897132[56]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008587

imaginal disc-derived wing margin morphogenesis

FB:FBrf0190498
PMID:16326033[57]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008587

imaginal disc-derived wing margin morphogenesis

FB:FBrf0199183
PMID:15452147[44]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008587

imaginal disc-derived wing margin morphogenesis

FB:FBrf0207263
PMID:19027066[58]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009608

response to symbiont

FB:FBrf0151854
PMID:12445385[59]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009952

anterior/posterior pattern specification

FB:FBrf0107500
PMID:9988212[60]

TAS: Traceable Author Statement

P

From FB

GO:0010001

glial cell differentiation

FB:FBrf0191976
PMID:17157832[53]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0010629

negative regulation of gene expression

FB:FBrf0200192
PMID:16828735[61]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016021

integral to membrane

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR010660
InterPro:IPR011656

C

From FB

GO:0016330

second mitotic wave involved in compound eye morphogenesis

FB:FBrf0141762
PMID:11735386[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0016333

morphogenesis of follicular epithelium

FB:FBrf0139618
PMID:11591336[23]

NAS: Non-traceable Author Statement

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0078010

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0103246
PMID:9642168[2]

TAS: Traceable Author Statement

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0190110
PMID:16223477[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030708

germarium-derived female germ-line cyst encapsulation

FB:FBrf0139618
PMID:11591336[23]

TAS: Traceable Author Statement

P

From FB

GO:0030713

ovarian follicle cell stalk formation

FB:FBrf0091297
PMID:9012507[62]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030713

ovarian follicle cell stalk formation

FB:FBrf0128450
PMID:10822261[63]

TAS: Traceable Author Statement

P

From FB

GO:0030713

ovarian follicle cell stalk formation

FB:FBrf0167471
PMID:14536057[64]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030718

germ-line stem cell maintenance

FB:FBrf0201538
PMID:17287246[65]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

FB:FBrf0167471
PMID:14536057[64]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035003

subapical complex

FB:FBrf0192755
PMID:17212657[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0035153

epithelial cell type specification, open tracheal system

FB:FBrf0192962
PMID:16760977[66]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035155

negative regulation of terminal cell fate specification, open tracheal system

FB:FBrf0125237
PMID:10684581[37]

TAS: Traceable Author Statement

P

From FB

GO:0035157

negative regulation of fusion cell fate specification

FB:FBrf0125237
PMID:10684581[37]

TAS: Traceable Author Statement

P

From FB

GO:0035162

embryonic hemopoiesis

FB:FBrf0155787
PMID:12569125[67]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035165

embryonic crystal cell differentiation

FB:FBrf0167476
PMID:14602069[68]

TAS: Traceable Author Statement

P

From FB

GO:0035167

larval lymph gland hemopoiesis

FB:FBrf0155787
PMID:12569125[67]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035170

lymph gland crystal cell differentiation

FB:FBrf0167434
PMID:14734104[69]

TAS: Traceable Author Statement

P

From FB

GO:0035171

lamellocyte differentiation

FB:FBrf0151854
PMID:12445385[59]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035172

hemocyte proliferation

FB:FBrf0155787
PMID:12569125[67]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035214

eye-antennal disc development

FB:FBrf0207392
PMID:18639538[70]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0036011

imaginal disc-derived leg segmentation

FB:FBrf0109019
PMID:10357895[71]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040008

regulation of growth

FB:FBrf0167548
PMID:14592975[72]

IGI: Inferred from Genetic Interaction

FB:FBgn0263289

P

From FB

GO:0040008

regulation of growth

FB:FBrf0167548
PMID:14592975[72]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0141375
PMID:11746233[73]

NAS: Non-traceable Author Statement

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0151712
PMID:12121634[74]

TAS: Traceable Author Statement

P

From FB

GO:0042676

compound eye cone cell fate commitment

FB:FBrf0151870
PMID:12419199[75]

TAS: Traceable Author Statement

P

From FB

GO:0042686

regulation of cardioblast cell fate specification

FB:FBrf0160590
PMID:12756185[49]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0151854
PMID:12445385[59]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0155787
PMID:12569125[67]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042689

regulation of crystal cell differentiation

FB:FBrf0158758
PMID:12732186[76]

TAS: Traceable Author Statement

P

From FB

GO:0043234

protein complex

FB:FBrf0200934
PMID:17535912[14]

IPI: Inferred from Physical Interaction

FB:FBgn0004837

C

From FB

GO:0045165

cell fate commitment

FB:FBrf0123421

NAS: Non-traceable Author Statement

P

From FB

GO:0045316

negative regulation of compound eye photoreceptor development

FB:FBrf0187397
PMID:16039641[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045463

R8 cell development

FB:FBrf0129916
PMID:10929403[1]

TAS: Traceable Author Statement

P

From FB

GO:0045465

R8 cell differentiation

FB:FBrf0144824
PMID:11880339[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0045466

R7 cell differentiation

FB:FBrf0161963
PMID:14505358[77]

TAS: Traceable Author Statement

P

From FB

GO:0045466

R7 cell differentiation

FB:FBrf0207062
PMID:19118542[78]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045468

regulation of R8 cell spacing in compound eye

FB:FBrf0144824
PMID:11880339[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0045595

regulation of cell differentiation

FB:FBrf0209706
PMID:20056890[79]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045747

positive regulation of Notch signaling pathway

FB:FBrf0184061
PMID:15611340[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045750

positive regulation of S phase of mitotic cell cycle

FB:FBrf0187405
PMID:15809036[80]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0155963
PMID:12556495[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0046329

negative regulation of JNK cascade

FB:FBrf0151280
PMID:12147138[17]

NAS: Non-traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0151280
PMID:12147138[17]

NAS: Non-traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0151530
PMID:11932008[81]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0160550
PMID:12879451[82]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0160750
PMID:12879448[19]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0214518

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046666

retinal cell programmed cell death

FB:FBrf0156100
PMID:12547518[83]

TAS: Traceable Author Statement

P

From FB

GO:0046667

compound eye retinal cell programmed cell death

FB:FBrf0141762
PMID:11735386[3]

TAS: Traceable Author Statement

P

From FB

GO:0046843

dorsal appendage formation

FB:FBrf0190110
PMID:16223477[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048052

R1/R6 cell differentiation

FB:FBrf0207062
PMID:19118542[78]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0187471
PMID:16049109[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0167471
PMID:14536057[64]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048542

lymph gland development

FB:FBrf0180561
PMID:15286786[84]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048666

neuron development

FB:FBrf0190556
PMID:16547170[85]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048749

compound eye development

FB:FBrf0141375
PMID:11746233[73]

NAS: Non-traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0145168
PMID:11875444[40]

TAS: Traceable Author Statement

P

From FB

GO:0048803

imaginal disc-derived male genitalia morphogenesis

FB:FBrf0214470
PMID:21729695[86]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048863

stem cell differentiation

FB:FBrf0194773
PMID:17070683[87]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050767

regulation of neurogenesis

FB:FBrf0194325
PMID:17182870[88]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050768

negative regulation of neurogenesis

FB:FBrf0199183
PMID:15452147[44]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051489

regulation of filopodium assembly

FB:FBrf0213493
PMID:21447553[89]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061331

epithelial cell proliferation involved in Malpighian tubule morphogenesis

FB:FBrf0144843
PMID:11861476[90]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061382

Malpighian tubule tip cell differentiation

FB:FBrf0123233
PMID:10625542[91]

IMP: Inferred from Mutant Phenotype

P

From FB

NOT

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0151712
PMID:12121634[74]

NAS: Non-traceable Author Statement

P

From FB

NOT

GO:0007615

anesthesia-resistant memory

FB:FBrf0179219
PMID:15220476[50]

IMP: Inferred from Mutant Phenotype

P

From FB

colocalizes_with

GO:0031410

cytoplasmic vesicle

FB:FBrf0190204
PMID:16137928[92]

IDA: Inferred from Direct Assay

C

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
  2. ↑ 2.0 2.1 Cooperstock RL & Lipshitz HD (1997) Control of mRNA stability and translation during Drosophila development. Semin Cell Dev Biol 8: 541-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page
  4. ↑ Dominguez M et al. (2004) Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster. Nat Genet 36: 31-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Reynolds-Kenneally J & Mlodzik M (2005) Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Dev Biol 285: 38-48 PubMed GONUTS page
  6. ↑ Larson DE et al. (2008) Cellular behavior in the developing Drosophila pupal retina. Mech Dev 125: 223-32 PubMed GONUTS page
  7. ↑ Tsuda L et al. (2006) An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. EMBO J 25: 3191-202 PubMed GONUTS page
  8. ↑ Gibson MC & Schubiger G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23: 691-7 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
  10. ↑ Matsuno K et al. (2002) Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development 129: 1049-59 PubMed GONUTS page
  11. ↑ Sakata T et al. (2004) Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Curr Biol 14: 2228-36 PubMed GONUTS page
  12. ↑ Wilkin MB et al. (2004) Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Curr Biol 14: 2237-44 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Sasaki N et al. (2007) Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. Genes Cells 12: 89-103 PubMed GONUTS page
  14. ↑ 14.0 14.1 Kelly DF et al. (2007) Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless. Proc Natl Acad Sci U S A 104: 9591-6 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Kim IM et al. (2010) Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res 106: 1233-43 PubMed GONUTS page
  16. ↑ 16.0 16.1 Fortini ME & Artavanis-Tsakonas S (1994) The suppressor of hairless protein participates in notch receptor signaling. Cell 79: 273-82 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
  18. ↑ 18.0 18.1 Park JM et al. (2003) Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 23: 1358-67 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 López-Schier H (2003) The polarisation of the anteroposterior axis in Drosophila. Bioessays 25: 781-91 PubMed GONUTS page
  20. ↑ 20.0 20.1 Major RJ & Irvine KD (2005) Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development 132: 3823-33 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Ahimou F et al. (2004) The adhesion force of Notch with Delta and the rate of Notch signaling. J Cell Biol 167: 1217-29 PubMed GONUTS page
  22. ↑ Grammont M & Irvine KD (2001) fringe and Notch specify polar cell fate during Drosophila oogenesis. Development 128: 2243-53 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 Roth S (2001) Drosophila oogenesis: coordinating germ line and soma. Curr Biol 11: R779-81 PubMed GONUTS page
  24. ↑ 24.0 24.1 24.2 Dobens L et al. (2005) Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis. Dev Biol 287: 425-37 PubMed GONUTS page
  25. ↑ Schober M et al. (2005) Function of the ETS transcription factor Yan in border cell migration. Development 132: 3493-504 PubMed GONUTS page
  26. ↑ Wang X et al. (2007) Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Dev Biol 301: 532-40 PubMed GONUTS page
  27. ↑ Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
  28. ↑ 28.0 28.1 Corbin V et al. (1991) A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67: 311-23 PubMed GONUTS page
  29. ↑ Udolph G et al. (2009) On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages. Dev Biol 336: 156-68 PubMed GONUTS page
  30. ↑ Udolph G et al. (2001) A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions. Development 128: 1457-66 PubMed GONUTS page
  31. ↑ 31.0 31.1 Van De Bor V & Giangrande A (2001) Notch signaling represses the glial fate in fly PNS. Development 128: 1381-90 PubMed GONUTS page
  32. ↑ Umesono Y et al. (2002) Context-dependent utilization of Notch activity in Drosophila glial determination. Development 129: 2391-9 PubMed GONUTS page
  33. ↑ Crowner D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol 13: 967-72 PubMed GONUTS page
  34. ↑ 34.0 34.1 Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
  35. ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
  36. ↑ Ramain P et al. (2001) Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol 11: 1729-38 PubMed GONUTS page
  37. ↑ 37.0 37.1 37.2 Zelzer E & Shilo BZ (2000) Cell fate choices in Drosophila tracheal morphogenesis. Bioessays 22: 219-26 PubMed GONUTS page
  38. ↑ Josten F et al. (2004) Cooperation of JAK/STAT and Notch signaling in the Drosophila foregut. Dev Biol 267: 181-9 PubMed GONUTS page
  39. ↑ 39.0 39.1 Weinkove D & Leevers SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr Opin Genet Dev 10: 75-80 PubMed GONUTS page
  40. ↑ 40.0 40.1 40.2 Curtiss J et al. (2002) Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol 4: E48-51 PubMed GONUTS page
  41. ↑ McNeill H (2000) Sticking together and sorting things out: adhesion as a force in development. Nat Rev Genet 1: 100-8 PubMed GONUTS page
  42. ↑ Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
  43. ↑ De Celis JF (2003) Pattern formation in the Drosophila wing: The development of the veins. Bioessays 25: 443-51 PubMed GONUTS page
  44. ↑ 44.0 44.1 44.2 Kamimura K et al. (2004) Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol 166: 1069-79 PubMed GONUTS page
  45. ↑ Crozatier M et al. (2003) Vein-positioning in the Drosophila wing in response to Hh; new roles of Notch signaling. Mech Dev 120: 529-35 PubMed GONUTS page
  46. ↑ Weber U et al. (2003) Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell 5: 559-70 PubMed GONUTS page
  47. ↑ Milán M & Cohen SM (2000) Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control? Dev Biol 217: 1-9 PubMed GONUTS page
  48. ↑ Bour BA et al. (2000) Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion. Genes Dev 14: 1498-511 PubMed GONUTS page
  49. ↑ 49.0 49.1 Han Z & Bodmer R (2003) Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130: 3039-51 PubMed GONUTS page
  50. ↑ 50.0 50.1 Ge X et al. (2004) Notch signaling in Drosophila long-term memory formation. Proc Natl Acad Sci U S A 101: 10172-6 PubMed GONUTS page
  51. ↑ Matsuno M et al. (2009) The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Proc Natl Acad Sci U S A 106: 310-5 PubMed GONUTS page
  52. ↑ Song JK & Giniger E (2011) Noncanonical Notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of Trio. Dev Dyn 240: 324-32 PubMed GONUTS page
  53. ↑ 53.0 53.1 Edenfeld G et al. (2007) Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev Biol 301: 27-37 PubMed GONUTS page
  54. ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  55. ↑ Wildonger J & Mann RS (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286: 507-20 PubMed GONUTS page
  56. ↑ Wesley CS & Mok LP (2003) Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch. Mol Cell Biol 23: 5581-93 PubMed GONUTS page
  57. ↑ Alexander SJ et al. (2006) Insertional inactivation of the L13a ribosomal protein gene of Drosophila melanogaster identifies a new Minute locus. Gene 368: 46-52 PubMed GONUTS page
  58. ↑ Peralta S et al. (2009) Notch down-regulation by endocytosis is essential for pigment cell determination and survival in the Drosophila retina. Mech Dev 126: 256-69 PubMed GONUTS page
  59. ↑ 59.0 59.1 59.2 Duvic B et al. (2002) Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Curr Biol 12: 1923-7 PubMed GONUTS page
  60. ↑ Wylie C (1999) Germ cells. Cell 96: 165-74 PubMed GONUTS page
  61. ↑ Ward EJ et al. (2006) Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types. Dev Biol 297: 461-70 PubMed GONUTS page
  62. ↑ Goode S et al. (1996) The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis. Development 122: 3863-79 PubMed GONUTS page
  63. ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  64. ↑ 64.0 64.1 64.2 Torres IL et al. (2003) A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell 5: 547-58 PubMed GONUTS page
  65. ↑ Song X et al. (2007) Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development 134: 1071-80 PubMed GONUTS page
  66. ↑ Ghabrial AS & Krasnow MA (2006) Social interactions among epithelial cells during tracheal branching morphogenesis. Nature 441: 746-9 PubMed GONUTS page
  67. ↑ 67.0 67.1 67.2 67.3 Lebestky T et al. (2003) A Serrate-expressing signaling center controls Drosophila hematopoiesis. Genes Dev 17: 348-53 PubMed GONUTS page
  68. ↑ Evans CJ et al. (2003) Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev Cell 5: 673-90 PubMed GONUTS page
  69. ↑ Meister M (2004) Blood cells of Drosophila: cell lineages and role in host defence. Curr Opin Immunol 16: 10-5 PubMed GONUTS page
  70. ↑ Wang LH et al. (2008) Temporal switching of regulation and function of eye gone (eyg) in Drosophila eye development. Dev Biol 321: 515-27 PubMed GONUTS page
  71. ↑ Rauskolb C & Irvine KD (1999) Notch-mediated segmentation and growth control of the Drosophila leg. Dev Biol 210: 339-50 PubMed GONUTS page
  72. ↑ 72.0 72.1 Brumby AM & Richardson HE (2003) scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22: 5769-79 PubMed GONUTS page
  73. ↑ 73.0 73.1 Luo H & Dearolf CR (2001) The JAK/STAT pathway and Drosophila development. Bioessays 23: 1138-47 PubMed GONUTS page
  74. ↑ 74.0 74.1 McNeill H (2002) Planar polarity: location, location, location. Curr Biol 12: R449-51 PubMed GONUTS page
  75. ↑ Lai EC (2002) Developmental signaling: shrimp and strawberries help flies make cones. Curr Biol 12: R722-4 PubMed GONUTS page
  76. ↑ Evans CJ & Banerjee U (2003) Transcriptional regulation of hematopoiesis in Drosophila. Blood Cells Mol Dis 30: 223-8 PubMed GONUTS page
  77. ↑ Cook T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25: 921-5 PubMed GONUTS page
  78. ↑ 78.0 78.1 Bhattacharya A & Baker NE (2009) The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye. Dev Biol 327: 288-300 PubMed GONUTS page
  79. ↑ Mathur D et al. (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327: 210-3 PubMed GONUTS page
  80. ↑ Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
  81. ↑ Arias AM (2002) New alleles of Notch draw a blueprint for multifunctionality. Trends Genet 18: 168-70 PubMed GONUTS page
  82. ↑ Ghysen A & Thomas R (2003) The formation of sense organs in Drosophila: a logical approach. Bioessays 25: 802-7 PubMed GONUTS page
  83. ↑ Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page
  84. ↑ Mandal L et al. (2004) Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm. Nat Genet 36: 1019-23 PubMed GONUTS page
  85. ↑ Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
  86. ↑ Lee G et al. (2011) UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. Dev Biol 356: 588-97 PubMed GONUTS page
  87. ↑ Ward EJ et al. (2006) Stem cells signal to the niche through the Notch pathway in the Drosophila ovary. Curr Biol 16: 2352-8 PubMed GONUTS page
  88. ↑ Wang H et al. (2006) Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev 20: 3453-63 PubMed GONUTS page
  89. ↑ Kuzina I et al. (2011) How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. Development 138: 1839-49 PubMed GONUTS page
  90. ↑ Sudarsan V et al. (2002) A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila. Development 129: 935-44 PubMed GONUTS page
  91. ↑ Wan S et al. (2000) Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules. Dev Biol 217: 153-65 PubMed GONUTS page
  92. ↑ Jafar-Nejad H et al. (2005) Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell 9: 351-63 PubMed GONUTS page
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