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FB:Mpk2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Mpk2 ( synonyms: CG5475, D-MPK2, D-P38a, D-p38, D-p38 MAPK, D-p38a, DMPK2, DmMPK2, Dmp38a, Dp38, Dp38a, ERK2, Erk-kinase-like, Erk2, P38, dMPK2, dp38, dp38a, group 2, mpk2, p38, p38 MAP kinase, p38 alpha, p38 mitogen-activated protein kinase, p38A, p38Ka, p38a, p38a MAP kinase, stress-activated kinase P38 ) | |
| Protein Name(s) | Mpk2, | |
| External Links | ||
| FB | FBgn0015765 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
FB:FBrf0100059 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:6876 |
P |
From FB |
||
| GO:0000165 |
MAPK cascade |
FB:FBrf0102625 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0000165 |
MAPK cascade |
FB:FBrf0128774 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0000165 |
MAPK cascade |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0002385 |
mucosal immune response |
FB:FBrf0208708 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0115705 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0100059 |
IGI: Inferred from Genetic Interaction |
SGD:S000004103 |
F |
From FB |
||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0100059 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:6876 |
F |
From FB |
||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0102625 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0115705 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004707 |
MAP kinase activity |
FB:FBrf0140137 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0140137 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0140137 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From FB |
||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0102625 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006970 |
response to osmotic stress |
FB:FBrf0100059 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0140137 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0216446 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008348 |
negative regulation of antimicrobial humoral response |
FB:FBrf0102625 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009408 |
response to heat |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016909 |
SAP kinase activity |
FB:FBrf0128774 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0034614 |
cellular response to reactive oxygen species |
FB:FBrf0189754 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042542 |
response to hydrogen peroxide |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042594 |
response to starvation |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042742 |
defense response to bacterium |
FB:FBrf0212390 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045793 |
positive regulation of cell size |
FB:FBrf0209636 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0024846 |
P |
From FB |
||
| GO:0048082 |
regulation of adult chitin-containing cuticle pigmentation |
FB:FBrf0215011 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0014006 |
P |
From FB |
||
| GO:0050832 |
defense response to fungus |
FB:FBrf0212390 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071243 |
cellular response to arsenic-containing substance |
FB:FBrf0189754 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0071276 |
cellular response to cadmium ion |
FB:FBrf0189754 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0080134 |
regulation of response to stress |
FB:FBrf0216446 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Han SJ et al. (1998) Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. J Biol Chem 273: 369-74 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Han ZS et al. (1998) A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol 18: 3527-39 PubMed GONUTS page
- ↑ 3.0 3.1 Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
- ↑ Ha EM et al. (2009) Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol 10: 949-57 PubMed GONUTS page
- ↑ 5.0 5.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 6.0 6.1 Vrailas-Mortimer A et al. (2011) A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila. Dev Cell 21: 783-95 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Cully M et al. (2010) A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol 30: 481-95 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Ryabinina OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol 7: 7 PubMed GONUTS page
- ↑ 9.0 9.1 Chen J et al. (2010) Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc Natl Acad Sci U S A 107: 20774-9 PubMed GONUTS page
- ↑ Sekine Y et al. (2011) p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J Cell Sci 124: 3006-16 PubMed GONUTS page
