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FB:Mhc

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Mhc ( synonyms: Bsh, CG17927, DROMHC, Dm II, DmMHC, DroMII, FBgn0002741, Ifm(2)2, MHC, MRP, Mhc36B, Mrp, Muscle myosin heavy chain, MyHC, Myo, Myosin, Myosin Heavy Chain, Myosin rod protein, Not-upheld, Nup, Samba, Shrunken thorax, Shrunken-thorax, Sht, Stp, Stuckup, beta-myosin heavy chain, chain, heavy chain, ifm(2)2, l(2)36Ae, l(2)M66, l(2)k10423, mMHC, mhc, muscle myosin, muscle myosin II, muscle myosin II heavy chain, muscle myosin heavy chain, muscle myosin-II, muscle specific myosin II, myosin, myosin heavy, myosin heavy chain, myosin heavy-chain, myosin heavy-chain protein, sMHC, sarcomeric myosin heavy-chain )
Protein Name(s) Myosin heavy chain,
External Links
FB FBgn0086783

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000146

microfilament motor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P79293

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001609
InterPro:IPR004009

F

From FB

GO:0005859

muscle myosin complex

FB:FBrf0053881
PMID:1907912[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005859

muscle myosin complex

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P79293

C

From FB

GO:0005863

striated muscle myosin thick filament

FB:FBrf0053881
PMID:1907912[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0006936

muscle contraction

FB:FBrf0091179
PMID:8995523[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006941

striated muscle contraction

FB:FBrf0053881
PMID:1907912[1]

TAS: Traceable Author Statement

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0202362
PMID:17603108[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0053881
PMID:1907912[1]

TAS: Traceable Author Statement

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0091179
PMID:8995523[2]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0016459

myosin complex

FB:FBrf0132100
PMID:10908588[4]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0030017

sarcomere

FB:FBrf0091179
PMID:8995523[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0030239

myofibril assembly

FB:FBrf0174807
PMID:15075240[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030241

skeletal muscle myosin thick filament assembly

FB:FBrf0162218
PMID:12927543[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0031672

A band

FB:FBrf0202672
PMID:18199432[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0040011

locomotion

FB:FBrf0091196
PMID:8887536[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042623

ATPase activity, coupled

FB:FBrf0132100
PMID:10908588[4]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0042623

ATPase activity, coupled

FB:FBrf0141274

ISS: Inferred from Sequence or Structural Similarity

protein_id:AAC24207

F

From FB

GO:0042692

muscle cell differentiation

FB:FBrf0190120
PMID:16297904[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0091179
PMID:8995523[2]

IDA: Inferred from Direct Assay

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Kronert WA et al. (1991) Muscle-specific accumulation of Drosophila myosin heavy chains: a splicing mutation in an alternative exon results in an isoform substitution. EMBO J 10: 2479-88 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Standiford DM et al. (1997) Myosin rod protein: a novel thick filament component of Drosophila muscle. J Mol Biol 265: 40-55 PubMed GONUTS page
  3. Chanut-Delalande H et al. (2007) A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics 176: 2177-87 PubMed GONUTS page
  4. 4.0 4.1 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
  5. Nongthomba U et al. (2004) Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle. J Cell Sci 117: 1795-805 PubMed GONUTS page
  6. Polyák E et al. (2003) Contribution of myosin rod protein to the structural organization of adult and embryonic muscles in Drosophila. J Mol Biol 331: 1077-91 PubMed GONUTS page
  7. Hudson AM et al. (2008) Mononuclear muscle cells in Drosophila ovaries revealed by GFP protein traps. Dev Biol 314: 329-40 PubMed GONUTS page
  8. Wells L et al. (1996) Myosin heavy chain isoforms regulate muscle function but not myofibril assembly. EMBO J 15: 4454-9 PubMed GONUTS page
  9. Gajewski KM et al. (2006) Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscle. Dev Biol 289: 17-29 PubMed GONUTS page
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