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FB:Mer
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Mer ( synonyms: BG01543, CG14228, D Merlin, D-Mer, Dmerlin, EMR2, Emr2, Ezrin-moesin-radixin-2, Merlin/Neurofibromin 2, mer, merlin ) | |
| Protein Name(s) | Merlin, | |
| External Links | ||
| FB | FBgn0086384 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001558 |
regulation of cell growth |
FB:FBrf0088536 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0001745 |
compound eye morphogenesis |
FB:FBrf0211036 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0259685 |
P |
From FB |
||
| GO:0001751 |
compound eye photoreceptor cell differentiation |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0088536 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000117 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0088536 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011661 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0125175 |
IPI: Inferred from Physical Interaction |
FB:FBgn0004583 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0210017 |
IPI: Inferred from Physical Interaction |
FB:FBgn0053193 |
F |
From FB |
||
| GO:0005737 |
cytoplasm |
FB:FBrf0088536 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0091300 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0102961 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005856 |
cytoskeleton |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0091300 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005912 |
adherens junction |
FB:FBrf0088536 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0205210 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006897 |
endocytosis |
FB:FBrf0088536 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0007050 |
cell cycle arrest |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0007112 |
male meiosis cytokinesis |
FB:FBrf0205210 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007267 |
cell-cell signaling |
FB:FBrf0088536 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0007283 |
spermatogenesis |
FB:FBrf0205210 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0205210 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008092 |
cytoskeletal protein binding |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008092 |
cytoskeletal protein binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000798 |
F |
From FB |
||
| GO:0008101 |
decapentaplegic signaling pathway |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000490 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0125175 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0194966 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009798 |
axis specification |
FB:FBrf0134575 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009966 |
regulation of signal transduction |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0016006 |
Nebenkern |
FB:FBrf0205210 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0102961 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016324 |
apical plasma membrane |
FB:FBrf0125175 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0019094 |
pole plasm mRNA localization |
FB:FBrf0180506 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019898 |
extrinsic to membrane |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000798 |
C |
From FB |
||
| GO:0032456 |
endocytic recycling |
FB:FBrf0190031 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0035329 |
hippo signaling cascade |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261456 |
P |
From FB |
||
| GO:0042048 |
olfactory behavior |
FB:FBrf0192106 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0102961 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042327 |
positive regulation of phosphorylation |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0042981 |
regulation of apoptotic process |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0045595 |
regulation of cell differentiation |
FB:FBrf0125175 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0191261 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004583 |
P |
From FB |
||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046669 |
regulation of compound eye retinal cell programmed cell death |
FB:FBrf0200171 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
NOT |
GO:0045169 |
fusome |
FB:FBrf0091300 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 McCartney BM & Fehon RG (1996) Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J Cell Biol 133: 843-52 PubMed GONUTS page
- ↑ Ling C et al. (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A 107: 10532-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Maitra S et al. (2006) The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol 16: 702-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 McCartney BM et al. (2000) The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127: 1315-24 PubMed GONUTS page
- ↑ Yu J et al. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18: 288-99 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 de Cuevas M et al. (1996) alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary. Development 122: 3959-68 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 LaJeunesse DR et al. (1998) Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization. J Cell Biol 141: 1589-99 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Dorogova NV et al. (2008) The role of Drosophila Merlin in spermatogenesis. BMC Cell Biol 9: 1 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Hamaratoglu F et al. (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8: 27-36 PubMed GONUTS page
- ↑ Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ Willecke M et al. (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 16: 2090-100 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Pellock BJ et al. (2007) The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol 304: 102-15 PubMed GONUTS page
- ↑ MacDougall N et al. (2001) Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte. Development 128: 665-73 PubMed GONUTS page
- ↑ Herpers B & Rabouille C (2004) mRNA localization and ER-based protein sorting mechanisms dictate the use of transitional endoplasmic reticulum-golgi units involved in gurken transport in Drosophila oocytes. Mol Biol Cell 15: 5306-17 PubMed GONUTS page
- ↑ Sambandan D et al. (2006) Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster. Genetics 174: 1349-63 PubMed GONUTS page
